Mood and cognitive function following repeated transcranial direct current stimulation in healthy volunteers: A preliminary report

Motohashi, Nobutaka; Yamaguchi, Masayasu; Fujii, Tomokazu; Kitahara, Yoshinori

doi:10.1016/j.neures.2013.06.001

Cited by 30 publications

(16 citation statements)

References 30 publications

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“…Was shown to increase : a) working memory performance [21,41-49]; b) positive emotion processing [50-52]; c) pain thresholds [53] ; d) performance on verbal tasks (verbal; word retrieval:[54]; word fluency:[18]); e) executive function performance (mental flexibility: [22]; inhibition: [46]; problem solving: [24,55-56]; planning [15]); f) control of negative emotions [39,57]; g) memory performance and learning [25,27,58-60]. Showed no significant effect on: a) mood [61]. …”

Section: Resultsmentioning

confidence: 99%

The Uncertain Outcome of Prefrontal tDCS

et al. 2014

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Background Transcranial direct current stimulation (tDCS) is increasingly used in research and clinical settings, and the dorsolateral prefrontal cortex (DLPFC) is often chosen as a target for stimulation. While numerous studies report modulation of cognitive abilities following DLPFC stimulation, the wide array of cognitive functions that can be modulated makes it difficult to predict its precise outcome. Objective The present review aims at identifying and characterizing the various cognitive domains affected by tDCS over DLPFC. Methods Articles using tDCS over DLPFC indexed in PubMed and published between 2000 and January 2014 were included in the present review. Results tDCS over DLPFC affects a wide array of cognitive functions, with sometimes apparent conflicting results. Conclusion Prefrontal tDCS has the potential to modulate numerous cognitive functions simultaneously, but to properly interpret the results, a clear a priori hypothesis is necessary, careful technical consideration are mandatory, further insights into the neurobiological impact of tDCS are needed, and consideration should be given to the possibility that some behavioral effects may be partly explained by parallel modulation of related functions.

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Section: Resultsmentioning

confidence: 99%

The Uncertain Outcome of Prefrontal tDCS

et al. 2014

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“…In working memory tasks, both positive behavioural effects24262729 and null effects284546 of tDCS stimulation over DLPFC have been reported. A review25 concluded that performance in an n-back is not influenced by tDCS, whereas reaction time performance benefits from tDCS over DLPFC.…”

Section: Discussionmentioning

confidence: 99%

“…Although the increased activation in the DLPFC during the planning period of a bimanual coordination task fits nicely with the idea that the DLPFC links information (i.e., a visual cue) to the regulation of a forthcoming action (i.e., required movement), whether the DLPFC is actively regulating the bimanual movement (i.e., causality) is still elusive. Importantly, the effect of tDCS over DLPFC has only been investigated in the context of cognitive tasks (e.g., working memory and executive control task)242526272829, but the influence of enhanced DLPFC function on motor behaviour is largely unknown. Furthermore, effects of tDCS over M1 are mostly demonstrated in simple tasks, few studies have looked into more complex motor tasks93031.…”

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confidence: 99%

tDCS over left M1 or DLPFC does not improve learning of a bimanual coordination task

Vancleef

Meesen

Swinnen

et al. 2016

Sci Rep

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Previously, transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has resulted in improved performance in simple motor tasks. For a complex bimanual movement, studies using functional magnetic resonance imaging and transcranial magnetic stimulation indicated the involvement of the left dorsolateral prefrontal cortex (DLPFC) as well as left M1. Here we investigated the relative effect of up-regulating the cortical function in left DLPFC and left M1 with tDCS. Participants practised a complex bimanual task over four days while receiving either of five stimulation protocols: anodal tDCS applied over M1, anodal tDCS over DLPFC, sham tDCS over M1, sham tDCS over DLPFC, or no stimulation. Performance was measured at the start and end of each training day to make a distinction between acquisition and consolidation. Although task performance improved over days, no significant difference between stimulation protocols was observed, suggesting that anodal tDCS had little effect on learning the bimanual task regardless of the stimulation sites and learning phase (acquisition or consolidation). Interestingly, cognitive performance as well as corticomotor excitability did not change following stimulation. Accordingly, we found no evidence for behavioural or neurophysiological changes following tDCS over left M1 or left DLPFC in learning a complex bimanual task.

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“…The positive results described above were not always consistent across studies as other single-session studies using similar (though not identical) parameters did not find an effect on working memory [58,62], multi-tasking [61], or inhibition [63•].…”

Section: Findings In Healthy Subjects and Patientsmentioning

confidence: 78%

Transcranial Direct Current Stimulation (tDCS): Modulation of Executive Function in Health and Disease

Sarkis

Kaur

Camprodon

2014

Curr Behav Neurosci Rep

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Transcranial direct current stimulation (tDCS) is a noninvasive method of neuromodulation used in human basic and clinical neuroscience. In this article we review its use in the cognitive neurosciences to study executive function, and current preliminary explorations of its therapeutic value as a cognitive enhancer for patients with compromised dysexecutive symptoms. We discuss published studies analyzing their methodology and results. A number of experiments describe improvement in experimental measures of inhibitory control, working memory, and verbal fluency with anodal stimulation over the dorsolateral prefrontal cortex. Positive findings are also described in different clinical populations. Despite the growing promise and interest in tDCS given its safety, simplicity, and low cost, findings are not always consistent across studies due to a host of variables we discuss (study design, stimulation parameters, neuroanatomy, genetics, etc.), highlighting the need for a better mechanistic understanding of the effects of tDCS.

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Mood and cognitive function following repeated transcranial direct current stimulation in healthy volunteers: A preliminary report

Cited by 30 publications

References 30 publications

The Uncertain Outcome of Prefrontal tDCS

The Uncertain Outcome of Prefrontal tDCS

tDCS over left M1 or DLPFC does not improve learning of a bimanual coordination task

Transcranial Direct Current Stimulation (tDCS): Modulation of Executive Function in Health and Disease

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