Montmorillonite−Supramolecular Hydrogel Hybrid for Fluorocolorimetric Sensing of Polyamines

Ikeda, Masato; Yoshii, Tatsuyuki; Matsui, Toshihiro; Tanida, Tatsuya; Komatsu, Hikosaburo; Hamachi, Itaru

doi:10.1021/ja109692z

Cited by 158 publications

(119 citation statements)

References 23 publications

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“…Fluorescence turn-on assay of spermine and spermidine in artificial urine by using AuNPs/2-PR 3 + adsorbate: According to the method reported previously, [18] artificial urine was prepared by mixing lactic acid (1.1 mm), citric acid (2.0 mm), sodium bicarbonate (25 mm), urea (170 mm), calcium chloride (2.5 mm), sodium chloride (90 mm), magnesium sulfate (2.0 mm), sodium sulfate (10 mm), potassium dihydrogen phosphate (7.0 mm), dipotassium hydrogen phosphate (7.0 mm) and ammonium chloride (25 mm) in deionized water. The pH of the solution was adjusted to 6.0.…”

Section: Methodsmentioning

confidence: 99%

A Gold Nanoparticle‐Based Fluorescence Turn‐On Probe for Highly Sensitive Detection of Polyamines

Kim

Park

Kim

2011

Chemistry A European J

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Section: Methodsmentioning

confidence: 99%

A Gold Nanoparticle‐Based Fluorescence Turn‐On Probe for Highly Sensitive Detection of Polyamines

Kim

Park

Kim

2011

Chemistry A European J

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“…Hamachi et al fabricated a fluorocolourimetric sensor for the detection of the important cancer biomarker spermine and spermidine in artificial urine. 277 The naturally abundant anionic layered material montmorillonite (MMT) served as the host in supramolecular hydrogel to facilitate the aggregation of the cationic fluorescent probe. The adsorbed cationic probe illustrated a weak greenish, excimer emission, which converted to an intensified blue, monomer emission through its release via the cation-exchange with spermine or spermidine and the subsequent translocation to the supramolecular fibres.…”

Section: Small Chemical Products Of Cellular Metabolismmentioning

confidence: 99%

Cancer biomarker detection: recent achievements and challenges

2015

Chem. Soc. Rev.

948

565

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The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus, a great deal of effort has been devoted to the exploration of new technologies to detect early signs of the disease. Cancer biomarkers cover a broad range of biochemical entities, such as nucleic acids, proteins, sugars, small metabolites, and cytogenetic and cytokinetic parameters, as well as entire tumour cells found in the body fluid. They can be used for risk assessment, diagnosis, prognosis, and for the prediction of treatment efficacy and toxicity and recurrence. In this review, we provide an overview of recent advances in cancer biomarker detection. Several representative examples using different approaches for each biomarker have been reviewed, and all these cases demonstrate that the multidisciplinary technology-based cancer diagnostics are becoming an increasingly relevant alternative to traditional techniques. In addition, we also discuss the unsolved problems and future challenges in the evaluation of cancer biomarkers. Clearly, solving these hurdles requires great effort and collaboration from different communities of chemists, physicists, biologists, clinicians, material-scientists, and engineering and technical researchers. A successful outcome will result in the realization of point-of-care diagnosis and individualized treatment of cancers by non-invasive and convenient tests in the future.

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“…Such a sensor showed an excellent reproducibility of the signal output voltage. A recent breakthrough by Ikeda et al 163 featured a semi-wet fluorescent sensor by integrating supramolecular hydrogels with montmorillonite. Moreover, cationic coumarin dyes were intercalated into the interlayer space of montmorillonite for probing spermine and spermidine, as these can be used as biomarkers for assessing the effectiveness of cancer chemotherapy (Fig.…”

mentioning

confidence: 99%

Recent advances in clay mineral-containing nanocomposite hydrogels

et al. 2015

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Clay mineral-containing nanocomposite hydrogels have been proven to have exceptional composition, properties, and applications, and consequently have attracted a significant amount of research effort over the past few years. The objective of this paper is to summarize and evaluate scientific advances in clay mineral-containing nanocomposite hydrogels in terms of their specific preparation, formation mechanisms, properties, and applications, and to identify the prevailing challenges and future directions in the field. The state-of-the-art of existing technologies and insights into the exfoliation of layered clay minerals, in particular montmorillonite and LAPONITE s , are discussed first. The formation and structural characteristics of polymer/clay nanocomposite hydrogels made from in situ free radical polymerization, supramolecular assembly, and freezing-thawing cycles are then examined. Studies indicate that additional hydrogen bonding, electrostatic interactions, coordination bonds, hydrophobic interaction, and even covalent bonds could occur between the clay mineral nanoplatelets and polymer chains, thereby leading to the formation of unique three-dimensional networks. Accordingly, the hydrogels exhibit exceptional optical and mechanical properties, swelling-deswelling behavior, and stimuli-responsiveness, reflecting the remarkable effects of clay minerals. With the pivotal roles of clay minerals in clay mineral-containing nanocomposite hydrogels, the nanocomposite hydrogels possess great potential as superabsorbents, drug vehicles, tissue scaffolds, wound dressing, and biosensors. Future studies should lay emphasis on the formation mechanisms with in-depth insights into interfacial interactions, the tactical functionalization of clay minerals and polymers for desired properties, and expanding of their applications.

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Montmorillonite−Supramolecular Hydrogel Hybrid for Fluorocolorimetric Sensing of Polyamines

Cited by 158 publications

References 23 publications

A Gold Nanoparticle‐Based Fluorescence Turn‐On Probe for Highly Sensitive Detection of Polyamines

A Gold Nanoparticle‐Based Fluorescence Turn‐On Probe for Highly Sensitive Detection of Polyamines

Cancer biomarker detection: recent achievements and challenges

Recent advances in clay mineral-containing nanocomposite hydrogels

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