Monte Carlo simulation of the CENBG microbeam and nanobeam lines with the Geant4 toolkit

Incerti, S.; Zhang, Q.; Андерссон, Фредрик; Moretto, Ph.; Grime, G.W.; Merchant, Michael J; Nguyen, Duc Ton; Habchi, C.; Pouthier, T.; Seznec, Hervé

doi:10.1016/j.nimb.2007.01.274

Cited by 33 publications

(22 citation statements)

References 8 publications

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“…[11,12] Furthermore, weak intensities and the choice of protons as the ion beam allow the target degradation to be minimized during irradiation. However, intensities are sufficient to permit measurement duration below 1 h. An 80 mm 2 Si(Li) detector was used for X-ray detection, orientated at 1358 with respect to the incident beam axis, and equipped with a 12 mm thick beryllium window.…”

Section: Quantitative Analysis With Pixe-rbs Methods and Experimentalmentioning

confidence: 99%

Quantitative Chemical Mapping of Relevant Trace Elements at Biomaterials/Biological Media Interfaces by Ion Beam Methods

et al. 2010

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The definition of biomaterial as proposed by the European Society for Biomaterials in 1986 puts forward the overall importance of the notion of contact between the biomaterial and biological medium (cell, tissue, fluid,...). The underlying concept of biocompatibility makes the interface between biomaterial and biological medium a privileged zone of interest. In this paper, we would like to give an exhaustive view of how ion beams techniques can contribute to a better understanding of such interface taking several examples dealing with bone tissue substitution. After a short presentation of ion beams techniques the paper will focus on PIXE/RBS spectroscopies and will give the basics of these coupled technique. Three examples will then be presented to illustrate the interest of these techniques to study biomaterials/biological interactions. The first example deals with metallic alloys based joint prostheses. The ionic release from the prosthesis and the wear behavior of total knee prostheses will be presented. In the last two examples, bioactive materials will be studied. The common characteristic of bioactive ceramics is the kinetic modification of their surface upon interaction which is ideally monitored by PIXE chemical mapping. The second example will review the benefit of using PIXE/RBS technique to study the effect of doping of bioactive glasses on the very first steps involved in the bioactivity mechanisms like dissolution, ionic release, and biomineralization onto the surface of the glasses. Finally, protein delivery systems based upon mesoporous hydroxyapatites will be studied. Chemical mapping allowing the quantitative determination of protein distribution inside the HAp grains will be presented for the first time

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Section: Quantitative Analysis With Pixe-rbs Methods and Experimentalmentioning

confidence: 99%

Quantitative Chemical Mapping of Relevant Trace Elements at Biomaterials/Biological Media Interfaces by Ion Beam Methods

et al. 2010

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“…The CENBG nanobeam line design has been presented in detail previously [8][9][10]. Briefly, it is installed at the 0° output of the 3.5 MV Singletron™ (HVEE, The Netherlands) switching magnet.…”

Section: The Cenbg Nanobeam Linementioning

confidence: 99%

“…A long working distance doublet-triplet configuration was chosen as it presents a good compromise between high demagnification and low spherical aberrations [8,9]. First order calculations allow predicting demagnifications of 65 and 100 in the vertical and horizontal directions, respectively.…”

Section: Introductionmentioning

confidence: 99%

First results obtained using the CENBG nanobeam line: Performances and applications

Barberet

Daudin

Gordillo

et al. 2011

Nuclear Instruments and Methods in Physics Research Section B:

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Keywords: Ion nanobeam uclear microprobe Magnetic quadrupoles Ion beam optics Ion beam analysisA high resolution focused beam line has been recently installed on the AIFIRA ("Applications Interdisciplinaires des Faisceaux d'lons en Region Aquitaine") facility at CENBG. This nanobeam line, based on a doublet-triplet configuration of Oxford Microbeam Ltd. OM-50™ quadrupoles, offers the opportunity to focus protons, deuterons and alpha particles in the MeV energy range to a sub-micrometer beam spot. The beam optics design has been studied in detail and optimized using detailed ray-tracing simulations and the full mechanical design of the beam line was reported in the Debrecen ICNMTA conference in 2008. During the last two years, the lenses have been carefully aligned and the target chamber has been fully equipped with particle and X-ray detectors, microscopes and precise positioning stages. The beam line is now operational and has been used for its first applications to ion beam analysis. Interestingly, this set-up turned out to be a very versatile tool for a wide range of applications. Indeed, even if it was not intended during the design phase, the ion optics configuration offers the opportunity to work either with a high current microbeam (using the triplet only) or with a lower current beam presenting a sub-micrometer resolution (using the doublet-triplet configuration).The performances of the CENBG nanobeam line are presented for both configurations. Quantitative data concerning the beam lateral resolutions at different beam currents are provided. Finally, the first results obtained for different types of application are shown, including nuclear reaction analysis at the micrometer scale and the first results on biological samples.

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“…[6,7]) and several groups are working on the design of the next generation of quadrupole focusing systems (e.g. [8][9][10]), often involving high demagnification multiple stage lenses. There is the exciting possibility that sub-100 nm beams will be routinely available in the near future.…”

Section: Focusing Mev Ions To Sub-micron Dimensionsmentioning

confidence: 99%

Materials Patterning and Characterisation at the Nanometre Scale Using Focused MeV Ion Beams: Present Achievements and Future Prospects

Grime

2009

Acta Phys. Pol. A

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A key phenomenon in the interaction of MeV ions and solids is that the energy transferred from the primary ions to the target electrons is high compared with atomic and molecular binding energies, but low compared with the ion energy. This means that there is a high probability of modifying the chemical properties of the material (for patterning) or of inducing the emission of electromagnetic radiation (for analysis), yet the path of particle is changed by a negligible amount, which means that focused beams remain sharp even after penetrating long depths into the material. Developments in focusing MeV ions in recent years have pushed the useable beam diameters into the sub-micrometre region, which means that nuclear microbeams are poised to make an impact in both direct write fabrication and micro-analysis at length scales of interest in nanotechnology or microbiology. This paper reviews the science and technology underlying the use of nuclear microbeams (ion solid interactions, focusing systems) and reports on the present status and trends of applications in sub-micron scale applications. Interactions between MeV ions and atoms: the key advantage of MeV ions in nanoscale applicationsMeV ions interact with the atoms of target materials through electrostatic forces between the charged electrons and nuclei of the atoms. Apart from a small fraction of ions which undergo large angle scattering resulting from a close approach to the nucleus (the Rutherford scattering), the primary effect of the interaction is to create a transient electric dipole excitation of the electron structure of the atom. Kinetic energy is absorbed from the ion and may result in ionisation or promoting one or more of the atomic electrons into excited states.The energy transferred from the ion to the atom depends on many factors, but can range from zero to a few tens of keV. This is large compared with electronic binding energies (especially those of valence electrons), giving a high probability of locally modifying the chemistry of the sample, but small compared with the primary ion energy, so that the ion is not strongly deflected or decelerated, and can undergo many thousands of atomic collisions while following an essentially straight path for a large part of its range. This is the unique advantage of MeV ions for high spatial resolution applications: there is a high probability of creating useful effects in the material, yet the primary ion has a long range and a straight path with low lateral scattering. This is demonstrated in Fig.

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Monte Carlo simulation of the CENBG microbeam and nanobeam lines with the Geant4 toolkit

Cited by 33 publications

References 8 publications

Quantitative Chemical Mapping of Relevant Trace Elements at Biomaterials/Biological Media Interfaces by Ion Beam Methods

Quantitative Chemical Mapping of Relevant Trace Elements at Biomaterials/Biological Media Interfaces by Ion Beam Methods

First results obtained using the CENBG nanobeam line: Performances and applications

Materials Patterning and Characterisation at the Nanometre Scale Using Focused MeV Ion Beams: Present Achievements and Future Prospects

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