Monte Carlo dose enhancement studies in microbeam radiation therapy

Martínez-Rovira, I.; Prezado, Yolanda

doi:10.1118/1.3603189

Cited by 29 publications

(32 citation statements)

References 77 publications

(66 reference statements)

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“…The peak doses are typically 20-100 times higher than the valley [5,6,7]. Small PVDRs indicate that the valley dose between adjacent microbeams, is large in relation to the peak dose.…”

Section: Introductionmentioning

confidence: 99%

“…MRT involves the application of an array of spatially fractionated microbeams sourced from third generation synchrotrons, with beam widths ranging from 25 to 75 µm, and a pitch of 200-400 µm [2][3][4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…Microbeam peak doses of between 500-1000 Gy can be delivered safely due to the wellknown dose volume effect [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Small PVDRs indicate that the valley dose between adjacent microbeams, is large in relation to the peak dose. When made comparable to the large peak doses, this indicates better tumour coverage [7,8]. Conversely, a large PVDR and small valley dose may be more accommodating for tissue recovery, allowing normal tissue to be spared through the dose-volume effect [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…In MRT, NPs may be useful by raising the local dose to the tumour, in particular to enhance the low valley dose at the site of the tumour [7]. NP use may in turn promote more normal tissue sparing, as peak doses could be lowered to induce the same clinical treatment outcome.…”

Section: Introductionmentioning

confidence: 99%

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Optimizing dose enhancement with Ta 2 O 5 nanoparticles for synchrotron microbeam activated radiation therapy

et al. 2016

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Microbeam Radiation Therapy (MRT) exploits tumour selectivity and normal tissue sparing with spatially fractionated kilovoltage X-ray microbeams through the dose volume effect. Experimental measurements with Ta 2 O 5 nanoparticles (NPs) in 9L gliosarcoma treated with MRT at the Australian Synchrotron, increased the treatment efficiency. Ta 2 O 5 NPs were observed to form shells around cell nuclei which may be the reason for their efficiency in MRT. In this article, our experimental observation of NP shell formation is the basis of a Geant4 radiation transport study to characterise dose enhancement by Ta 2 O 5 NPs in MRT. Our study showed that NP shells enhance the physical dose depending microbeam energy and their location relative to a single microbeam. For monochromatic microbeam energies below ∼70 keV, NP shells show highly localised dose enhancement due to the short range of associated secondary electrons. Low microbeam energies indicate better targeted treatment by allowing higher microbeam doses to be administered to tumours and better exploit the spatial fractionation related selectivity observed with MRT. For microbeam energies above ∼100 keV, NP shells extend the physical dose enhancement due to longer-range secondary electrons. Again, with NPs selectively internalised, the local effectiveness of MRT is expected to increase in the tumour. Dose enhancement produced by the shell aggregate varied more significantly in the cell population, depending on its location, when compared to a homogeneous NP distribution. These combined simulation and experimental data provide first evidence for optimising MRT through the incorporation of newly observed Ta 2 O 5 NP distributions within 9L cancer cells. Disciplines Engineering | Science and Technology Studies Publication DetailsEngels, E., Corde, S., McKinnon, S., Incerti, S., Konstantinov, K., Rozenfeld, A., Tehei, M., . Optimizing dose enhancement with Ta2O5 nanoparticles for synchrotron microbeam activated radiation therapy. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 32 (12)

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“…The peak doses are typically 20-100 times higher than the valley [5,6,7]. Small PVDRs indicate that the valley dose between adjacent microbeams, is large in relation to the peak dose.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Microbeam peak doses of between 500-1000 Gy can be delivered safely due to the wellknown dose volume effect [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optimizing dose enhancement with Ta 2 O 5 nanoparticles for synchrotron microbeam activated radiation therapy

et al. 2016

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Rare Earth Nanoprobes for Targeted Delineation of Triple Negative Breast Cancer and Enhancement of Radioimmunotherapy

Ming,

Zhang,

Song

et al. 2024

Advanced Science

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Radiotherapy demonstrates a synergistic effect with immunotherapy by inducing a transformation of “immune cold” tumors into “immune hot” tumors in triple negative breast cancer (TNBC). Nevertheless, the effectiveness of immunotherapy is constrained by low expression of tumor‐exposed antigens, inadequate inflammation, and insufficient tumor infiltrating lymphocyte (TILs). To address this predicament, novel lutecium‐based rare earth nanoparticles (RENPs) are synthesized with the aim of amplifying radiation effect and tumor immune response. The nanoprobe is characterized by neodymium‐based down‐conversion fluorescence, demonstrating robust photostability, biocompatibility, and targetability. The conjugation of RENPs with a CXCR4 targeted drug enables precise delineation of breast tumors using a near‐infrared imaging system and improves radiation efficacy via lutetium‐based radio‐sensitizer in vivo. Furthermore, the study shows a notable enhancement of immune response through the induction of immunogenic cell death and recruitment of TILs, resulting in the inhibition of tumor progression both in vitro and in vivo models following the administration of nanoparticles. Hence, the novel multifunctional nanoprobes incorporating various lanthanide elements offer the potential for imaging‐guided tumor delineation, radio‐sensitization, and immune activation post‐radiation, thus presenting an efficient radio‐immunotherapeutic approach for TNBC.

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Impact of cardiosynchronous brain pulsations on Monte Carlo calculated doses for synchrotron micro‐ and minibeam radiation therapy

Sola

Vilches²,

Prezado

et al. 2018

Medical Physics

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Monte Carlo dose enhancement studies in microbeam radiation therapy

Cited by 29 publications

References 77 publications

Optimizing dose enhancement with Ta 2 O 5 nanoparticles for synchrotron microbeam activated radiation therapy

Optimizing dose enhancement with Ta 2 O 5 nanoparticles for synchrotron microbeam activated radiation therapy

Rare Earth Nanoprobes for Targeted Delineation of Triple Negative Breast Cancer and Enhancement of Radioimmunotherapy

Impact of cardiosynchronous brain pulsations on Monte Carlo calculated doses for synchrotron micro‐ and minibeam radiation therapy

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