2016
DOI: 10.1016/j.ejmp.2016.10.024
|View full text |Cite
|
Sign up to set email alerts
|

Optimizing dose enhancement with Ta 2 O 5 nanoparticles for synchrotron microbeam activated radiation therapy

Abstract: Microbeam Radiation Therapy (MRT) exploits tumour selectivity and normal tissue sparing with spatially fractionated kilovoltage X-ray microbeams through the dose volume effect. Experimental measurements with Ta 2 O 5 nanoparticles (NPs) in 9L gliosarcoma treated with MRT at the Australian Synchrotron, increased the treatment efficiency. Ta 2 O 5 NPs were observed to form shells around cell nuclei which may be the reason for their efficiency in MRT. In this article, our experimental observation of NP shell form… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
9
0
2

Year Published

2017
2017
2021
2021

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 23 publications
(17 citation statements)
references
References 34 publications
1
9
0
2
Order By: Relevance
“…The results of this research have significant impact on studies which intend to investigate the physics mechanism at the basis of the radiobiological effects of radiation at cellular and sub-cellular level in radiotherapeutic applications (Incerti et al 2016), such as the investigation of dose enhancement produced by high-Z nanoparticles (e.g. (Sakata et al 2016, Douglass et al 2013, Engels et al 2016, McKinnon et al 2016a, McKinnon et al 2016b), the characterisation of radio-emitters for Targeted Particle Therapy (e.g. (Huang et al 2012)), the study of the effect of radiation in cellular targets other than the nucleus (e.g.…”
Section: Discussionmentioning
confidence: 99%
“…The results of this research have significant impact on studies which intend to investigate the physics mechanism at the basis of the radiobiological effects of radiation at cellular and sub-cellular level in radiotherapeutic applications (Incerti et al 2016), such as the investigation of dose enhancement produced by high-Z nanoparticles (e.g. (Sakata et al 2016, Douglass et al 2013, Engels et al 2016, McKinnon et al 2016a, McKinnon et al 2016b), the characterisation of radio-emitters for Targeted Particle Therapy (e.g. (Huang et al 2012)), the study of the effect of radiation in cellular targets other than the nucleus (e.g.…”
Section: Discussionmentioning
confidence: 99%
“…10 b, c) [ 117 ]. The same group also reported the dose enhancement effect of the NPs under a synchrotron beam with the energy range of 50–150 keV in 9L gliosarcoma cells [ 118 ].
Fig.
…”
Section: High-z Metal Nps For Radiotherapy Of Glioblastomamentioning
confidence: 99%
“… 60 Dose enhancement was looked at in relation to MRT, especially with nanoparticles. 61 , 62 Advice was produced for the optimal energy spectrum to be used in any clinical trials of MRT. 26 , 63 …”
Section: Grid-based Radiation Therapymentioning
confidence: 99%