Monoterpene‐rich resins from two ethiopian species of commiphora

Abegaz, Berhanu M.; Dagne, Ermias; Bates, Catherine; Waterman, Peter G.

doi:10.1002/ffj.2730040303

Cited by 11 publications

(5 citation statements)

References 5 publications

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“…Moreover, a previous study on the chemical composition of another Soqotri Commiphora species, namely C. kua [ 21 ], showed the absence of the major components in C. ornifolia and C. parvifolia such as camphor, α-fenchol, caryophyllene oxide and hexadecanoic acid. Generally, the comparison of our data with those of literature showed that the main constituents of chemical composition of the two investigated endemic Commiphora oils were markedly different from that of other known Commiphora species e.g., C. myrrha, C. kataf, C. holtziana, C. shaerocarpa, C. kua , C. opobalsamum and C. africana [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. The data obtained can be used as a chemotaxonomical marker for Commiphora sp.…”

Section: Resultssupporting

confidence: 43%

“…Such compounds e.g. α-pinene, β-pinene, p -cymene and α-thujene represented the most major compounds in many reported Commiphora oils [ 17 , 18 , 19 , 20 ]. Moreover, a previous study on the chemical composition of another Soqotri Commiphora species, namely C. kua [ 21 ], showed the absence of the major components in C. ornifolia and C. parvifolia such as camphor, α-fenchol, caryophyllene oxide and hexadecanoic acid.…”

Section: Resultsmentioning

confidence: 99%

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Chemical Analysis and Biological Activity of the Essential Oils of Two Endemic Soqotri Commiphora Species

2010

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The barks of two endemic Commiphora species namely, Commiphora ornifolia (Balf.f.) Gillett and Commiphora parvifolia Engl., were collected from Soqotra Island in Yemen and their essential oils were obtained by hydrodistillation. The chemical composition of both oils was investigated by GC and GC-MS. Moreover, the essential oils were evaluated for their antimicrobial activity against two Gram-positive bacteria, two Gram-negative bacteria and one yeast species by using a broth micro-dilution assay for minimum inhibitory concentrations (MIC) and for their antioxidant activity by measuring the DPPH radical scavenging activity. A total of 45 constituents of C. ornifolia (85.6%) and 44 constituents of C. parvifolia (87.1%) were identified. The oil of C. ornifolia was characterized by a high content of oxygenated monoterpenes (56.3%), of which camphor (27.3%), α-fenchol (15.5%), fenchone (4.4%) and borneol (2.9%) were identified as the main components. High contents of oxygenated sesquiterpenes (36.1%) and aliphatic acids (22.8%) were found in C. parvifolia oil, in which caryophyllene oxide (14.2%), β-eudesmol (7.7%), bulnesol (5.7%), T-cadinol (3.7%) and hexadecanoic acid (18.4%) predominated. The results of the antimicrobial assay showed that both oils exhibited moderate to high antibacterial activity especially against Gram-positive bacteria. C. ornifolia oil was the most active. In addition, the DPPH-radical scavenging assay exhibited only weak antioxidant activities for both oils at the high concentration tested.

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Section: Resultssupporting

confidence: 43%

Section: Resultsmentioning

confidence: 99%

Chemical Analysis and Biological Activity of the Essential Oils of Two Endemic Soqotri Commiphora Species

2010

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“…(occurs in southern Ethiopia) were examined. Both consist primarily of monoterpene hydrocarbons (no oxygenated derivatives were detected) with limonene 2 as the major component; the resin from C. t. was richer in sesquiterpenes (Table 9) 131 . Myrrh -Commiphora chemistry 3.7 δ-cadinene 65…”

Section: Compoundmentioning

confidence: 99%

Myrrh - Commiphora chemistry

Hanŭs¹,

Řezanka²,

Dembitsky³

et al. 2005

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

218

162

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Myrrh and opopanax has been used throughout history in incense and as a perfume. Since Bible times it has been used for the treatment of wounds. The first attempts to identify content compounds were almost 100 years ago. In this review we discuss the present state of knowledge in the chemistry of substances of Commiphora spp. General On this place we must mention the most known Commiphoras, namely Commiphora myrrha (Nees) Engl., true myrrh, officinal myrrh, Heera Bol tree; C. myrrha (Nees) Engler var molmol Engler (C. molmol Engl. ex Tschirch), Somalian myrrh; Commiphora abyssinica (Berg) Engler (syn. Commiphora madagascarensis Jacq.), Arabian myrrh, Abyssinian myrrh; Commiphora africana (A. Rich.) Engl., myrrh, African bdelium; Commiphora guidottii Chiov., sweet myrrh, habag-hady (name in Somalia);

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“…More than 300 molecules have already been described for the genus Commiphora whereby sesqui- and triterpenes are the predominating classes [ 2 ]. Several monoterpenes are also present in the volatile oil of some Commiphora species, such as C. opobalsamum , C. mukul , C. tenuis , and C. cyclophylla [ 3 , 4 , 5 ], but these were not detected by modern gas chromatography–mass spectrometry (GC-MS) analyses in C. myrrha [ 6 , 7 , 8 , 9 , 10 , 11 ]. Diterpenes of the abietane type occur only in some species, including C. myrrha [ 2 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Terpenoids from Myrrh and Their Cytotoxic Activity against HeLa Cells

et al. 2023

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The oleo–gum resin of Commiphora myrrha (Nees) Engl. has a long history of medicinal use, although many of its constituents are still unknown. In the present investigation, 34 secondary metabolites were isolated from myrrh resin using different chromatographic techniques (silica flash chromatography, CPC, and preparative HPLC) and their structures were elucidated with NMR spectroscopy, HRESIMS, CD spectroscopy, and ECD calculations. Among the isolated substances are seven sesquiterpenes (1–7), one disesquiterpene (8), and two triterpenes (23, 24), which were hitherto unknown, and numerous substances are described here for the first time for C. myrrha or the genus Commiphora. Furthermore, the effects of selected terpenes on cervix cancer cells (HeLa) were studied in an MTT-based in vitro assay. Three triterpenes were observed to be the most toxic with moderate IC50 values of 60.3 (29), 74.5 (33), and 78.9 µM (26). Due to the different activity of the structurally similar triterpenoids, the impact of different structural elements on the cytotoxic effect could be discussed and linked to the presence of a 1,2,3-trihydroxy substructure in the A ring. The influence on TNF-α dependent expression of the intercellular adhesion molecule 1 (ICAM-1) in human microvascular endothelial cells (HMEC-1) was also tested for 4–6, 9–11, 17, 18, 20, and 27 in vitro, but revealed less than 20% ICAM-1 reduction and, therefore, no significant anti-inflammatory activity.

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Monoterpene‐rich resins from two ethiopian species of commiphora

Cited by 11 publications

References 5 publications

Chemical Analysis and Biological Activity of the Essential Oils of Two Endemic Soqotri Commiphora Species

Chemical Analysis and Biological Activity of the Essential Oils of Two Endemic Soqotri Commiphora Species

Myrrh - Commiphora chemistry

Terpenoids from Myrrh and Their Cytotoxic Activity against HeLa Cells

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