Monosodium Thyroxine, Desiccated Thyroid and an Impure Sodium Salt of Thyroxine

Thompson, Willard O.; Thompson, Patricia J.; Dickie, Lois F. N.

doi:10.1001/archinte.1933.00160040082004

Cited by 20 publications

(2 citation statements)

References 22 publications

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“…However, Schittenheln & Eisler (1932) and Barnes & Bueno (1933), using Thiry-Vella fistulas in dogs, were able to show that thyroxine was absorbed from the closed intestinal loops. There is some evidence that the form in which thyroxine is administered has a bearing on its activity after oral administration, and Thompson, Thompson & Dickie (1933) found that thyroxine by this route was most active as the sodium salt and that it can be used successfully in the treatment of myxoedema (cf. also Hart & Maclagan, 1950).…”

mentioning

confidence: 99%

Absorption and excretion of the mono-sodium salt of thyroxine labelled with radioactive iodine

Clayton¹,

Free²,

Page³

et al. 1950

Biochemical Journal

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mentioning

confidence: 99%

Absorption and excretion of the mono-sodium salt of thyroxine labelled with radioactive iodine

Clayton¹,

Free²,

Page³

et al. 1950

Biochemical Journal

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“…The data leading to these conclusions were obtained with the goitre-prevention response in adult female rats and may not be applicable to man. Nevertheless, in man, thyroxine has been reported to be less active by mouth than by the parenteral route (Thompson, Thompson and Dickie, 1933 ;Blackburn and Keating, 1954), * Investigations made by one of us (W. F. D.) now include more than 25 different samples of thyroid powder from these three species and the molar thyroxine : liothyronine ratio has never been greater than 3 : 1.…”

Section: 4mentioning

confidence: 99%

The Relative Potencies of Thyroxine and Liothyronine by Oral and Subcutaneous Administration in the Rat

Wiberg¹,

Devlin²,

Stephenson³

et al. 1963

Journal of Pharmacy and Pharmacology

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In goitre prevention assays in adult female rats, thyroxine was only one-fifth to one-sixth as active by mouth as by subcutaneous injection whereas liothyronine had about the same biological activity for the two routes of administration. These findings provide an explanation for the fact that thyroxine was one-sixth to one-seventh as active as liothyronine when injected subcutaneously but only one-twentieth to one-thirtieth as potent when the hormones were administered orally. Chemical examination of three commercially available thyroxine samples which were labelled as "chromatographically pure" revealed that one of them contained approximately 10 per cent liothyronine. The presence of this contaminant had a marked influence on the biological responses of the test animals to this preparation.

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