Monosodium glutamate induced testicular toxicity and the possible ameliorative role of vitamin E or selenium in male rats

Hamza, Reham Z.; AL-Harbi, Mohammad S.

doi:10.1016/j.toxrep.2014.10.002

Cited by 74 publications

(68 citation statements)

References 52 publications

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“…The animals with blood glucose levels above 200 mg/dl were considered diabetic and were used in this study [15]. Monosodium glutamate (SigmaAldrich, St Louis, MO 63178, USA) was administrated intraperitoneally in two (low and high) dose levels (6 and 60 mg/kg body weight) [16].…”

Section: Methodsmentioning

confidence: 99%

Microscopic Study of Testicular Tissue Structure and Spermatogenesis Following Long Term Dose Dependent Administration of Monosodium Glutamate in Adult Diabetic Rats

Kianifard

2016

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Section: Methodsmentioning

confidence: 99%

Microscopic Study of Testicular Tissue Structure and Spermatogenesis Following Long Term Dose Dependent Administration of Monosodium Glutamate in Adult Diabetic Rats

Kianifard

2016

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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“…The organs of the reproductive system are targets of reactive oxygen species (ROS) because of adipose tissue present in these organs [13]. Studies have revealed an increase in the lipid peroxidation (malondialdehyde, MDA) and decreased antioxidant activity (reduced glutathione, GSH) as well as noticeable increase in testicular oxidative stress and a corresponding reduction in antioxidant/antioxidant enzyme activities after MSG administration [7,13,19]. Increased production of free radicals caused by MSG could lead to lipid peroxidation and sperm membrane dysfunction, sperm DNA damage, and impaired sperm movement.…”

Section: Oxidative Stressmentioning

confidence: 99%

“…MSG is formulated from water, glutamate, and sodium, and it is a major food flavor enhancer, which serves to exaggerate the inherent flavor of foods. The induction of myriad undesirable conditions such as weakness, numbness, muscle pain, headaches, dizziness, and flushing have been associated with MSG consumption [7]. Pre-clinical studies revealed that repeated MSG ingestion may also trigger asthma, cancer-induced obesity, diabetes, and oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

“…Glutamate can be metabolized into free amino acids absorbed into the gut for further breakdown [7]. The metabolized products include α-ketoglutarate via transamination (alanine transferase and aspartate transferase) and deamination using glutamate dehydrogenase, glutamine substrate through glutamine synthetase, and precursors for glutathione and N-acetylglutamine generation.…”

Section: Introductionmentioning

confidence: 99%

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Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review

Kayode

Rotimi

Kayode³

et al. 2020

Toxics

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Reproductive dysfunction is often characterized by malfunction of the reproductive tissues, which may lead to disruption of the synergistic rhythm that should bring about a progression of sexual events and the conception of new life. This may therefore result in the sexual dysfunction and infertility that can be seen in couples having prolonged biological difficulty in reproducing their offspring after having unrestricted sexual intercourse for at least twelve months. Several factors have been implicated in the cause and progression of reproductive dysfunction, including poor nutrition, drug side effects, disease states, and toxicant ingestion. A well-known food additive that has been found to be potent at initiating reproductive anomalies in males is monosodium glutamate (MSG). This regular flavor enhancer is widely used as a taste enhancer in several diets. The different mechanisms by which it may induce reproductive dysfunctions include spermatogenic alteration resulting in a low sperm count, high sperm abnormality, reduced live sperm and decreased sperm pH, oxidative damage (increased lipid peroxidation and reduced antioxidant enzyme activities), histological alteration (blood hemorrhage, distorted germ and Sertoli cells), as well as gonadotropin imbalance (reduced testosterone, luteinizing hormone, and follicle-stimulating hormone concentrations). Therefore, this review discusses various established mechanisms through which MSG may induce reproductive dysfunction and the treatment strategies to ameliorate its toxic effects.

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“…Monosodium glutamate (Sigma-Aldrich, St Louis, MO 63178, USA) was administrated intraperitoneally in two low (6 mg/kg body weight) and high (60 mg/ kg body weight) doses (Hamzaa et al, 2014). Methylphenidate hydrochloride (Sigma-Aldrich, St Louis, MO 63178, USA) was administrated intraperitoneally in two low (5 mg/kg body weight) and high (10 mg/kg body weight) doses (Take et al, 2008 (Helsinki, Finland, 1975).…”

Section: Treatments and Chemicalsmentioning

confidence: 99%

Study of the Long-Term and Dose Dependent Effects of Methylphenidate and Monosodium Glutamate on the Hormonal Alterations of the Pituitary-Testicular Axis and Sperm Analysis in Adolescence Rats

Abdollahzadeh¹,

Kianifard²,

Saiah³

2017

BUASVMCN-VM

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Methylphenidate is one of the most common medications that used for maintaining alertness and improving of attention which, may lead to increase of the risk of substance abuse in some cases. Monosodium glutamate is a food additive which has toxic effects on human and animal's tissues. Due to the various side effects of methylphenidate and monosodium glutamate on the reproductive system, the aim of this study was to evaluate the long-term and dose dependent effects of these compounds on the reproductive system during adolescence through hormonal and sperm analysis. Low and high dose of methylphenidate and monosodium glutamate was administrated to adolescent rats for 60 days. Body and testicular weight measurement, pituitary gonadotropins and testosterone levels assays and sperm analysis was performed on euthanized animals. The results showed that, high dose of methylphenidate and low dose of monosodium glutamate and/or combination form of these two compounds have more effects on body and testicular weight alterations. Low dose of methylphenidate with high dose of monosodium glutamate influenced some alterations in follicle stimulating hormone. The distinct use of methylphenidate and monosodium glutamate led to slight elevation in sperm count but simultaneous use of these compounds led to significant elevation of sperm count. The administration of these compounds had negative effect on sperm motility and viability. It has been concluded that, coadministration of methylphenidate and monosodium glutamate through the influence of brain-pituitary-testicular axis and induction of some hormonal alterations may lead to changes in normal function of reproductive system.

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Monosodium glutamate induced testicular toxicity and the possible ameliorative role of vitamin E or selenium in male rats

Abstract: HighlightsMonosodium glutamate induced testicular damage due to oxidative stress.Using of selenium and/or vitamin E to alleviate the toxicity of monosodium glutamate especially on testis.Increasing of MDA levels in MSG treated group while reduction in SOD, CAT and GPx activities.

Cited by 74 publications

References 52 publications

Microscopic Study of Testicular Tissue Structure and Spermatogenesis Following Long Term Dose Dependent Administration of Monosodium Glutamate in Adult Diabetic Rats

Microscopic Study of Testicular Tissue Structure and Spermatogenesis Following Long Term Dose Dependent Administration of Monosodium Glutamate in Adult Diabetic Rats

Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review

Study of the Long-Term and Dose Dependent Effects of Methylphenidate and Monosodium Glutamate on the Hormonal Alterations of the Pituitary-Testicular Axis and Sperm Analysis in Adolescence Rats

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