Monomethyl branched-chain fatty acids are critical for Caenorhabitis elegans survival in elevated glucose conditions

Vieira, Andre F.; Xatse, Mark Andy; Tifeki, Hamide; Diot, Cédric; Walhout, Albertha J.M.; Olsen, Carissa Perez

doi:10.1016/j.jbc.2021.101444

Cited by 11 publications

(35 citation statements)

References 35 publications

(54 reference statements)

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“…[ 43 ] Independent work has confirmed the role of PAQR‐2 in promoting fatty acid desaturation in response to cold or SFA‐rich diets, [ 48,49 ] and also showed that PAQR‐2 has a special function in glucose tolerance, namely boosting the production of mmBCFAs that may also help to fluidize membranes or act as signaling molecules. [ 50 ] Additionally, a chemical screen identified tyloxapol, a membrane‐fluidizing non‐ionic detergent, as a suppressor of paqr‐ 2 mutant phenotypes; this independently confirms that the primary defect in paqr‐2 mutants is membrane rigidity. [ 51 ] To summarize: PAQR‐2 acts together with IGLR‐2 to maintain membrane fluidity at low temperature or in the presence of dietary SFAs or glucose by upregulating Δ9 desaturase expression, mmBCFA production and promoting incorporation of PUFAs into phospholipids.…”

Section: Paqr Proteins and Membrane Homeostasismentioning

confidence: 89%

PAQR proteins and the evolution of a superpower: Eating all kinds of fats

Pilon

Ruiz

2023

BioEssays

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Recently published work showed that members of the PAQR protein family are activated by cell membrane rigidity and contribute to our ability to eat a wide variety of diets. Cell membranes are primarily composed of phospholipids containing dietarily obtained fatty acids, which poses a challenge to membrane properties because diets can vary greatly in their fatty acid composition and could impart opposite properties to the cellular membranes. In particular, saturated fatty acids (SFAs) can pack tightly and form rigid membranes (like butter at room temperature) while unsaturated fatty acids (UFAs) form more fluid membranes (like vegetable oils). Proteins of the PAQR protein family, characterized by the presence of seven transmembrane domains and a cytosolic N‐terminus, contribute to membrane homeostasis in bacteria, yeasts, and animals. These proteins respond to membrane rigidity by stimulating fatty acid desaturation and incorporation of UFAs into phospholipids and explain the ability of animals to thrive on diets with widely varied fat composition.

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Section: Paqr Proteins and Membrane Homeostasismentioning

confidence: 89%

PAQR proteins and the evolution of a superpower: Eating all kinds of fats

Pilon

Ruiz

2023

BioEssays

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“…BLCFA are vital for the development of C. elegans . , Iso- 17:0 is the key to the survival of C. elegans under high-glucose diet .…”

Section: Biological Activities Of Blcfamentioning

confidence: 99%

“…BLCFA are vital for the development of C. elegans . , Iso- 17:0 is the key to the survival of C. elegans under high-glucose diet . Meanwhile, deficiency of iso -17:0-derived glucosylceramide leads to developmental stagnation in C. elegans .…”

Section: Biological Activities Of Blcfamentioning

confidence: 99%

“…88,89 Iso-17:0 is the key to the survival of C. elegans under high-glucose diet. 90 Iso-17:0 increased mechanistic target of rapamycin complex 1 (mTORC1) signal transduction, thereby increasing glucose uptake and metabolism, rather than by regulating cell membrane fluidity. 90 Meanwhile, deficiency of iso-17:0-derived glucosylceramide leads to developmental stagnation in C. elegans.…”

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

“…90 Iso-17:0 increased mechanistic target of rapamycin complex 1 (mTORC1) signal transduction, thereby increasing glucose uptake and metabolism, rather than by regulating cell membrane fluidity. 90 Meanwhile, deficiency of iso-17:0-derived glucosylceramide leads to developmental stagnation in C. elegans. 91 Zhu et al further discovered that iso-17:0 mediated amino acid sensing upstream of mTORC1.…”

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

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