EAT-2 attenuates C. elegans development via metabolic remodeling in a chemically defined food environment

Cao, Xuwen; Xie, Yusu; Yang, Hanwen; Sun, Peiqi; Xue, Beining; García, L. René; Zhang, Liusuo

doi:10.1007/s00018-023-04849-x

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2023

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“…This is similar to what is observed in eat-2 mutant worms used as CR models that have increased lifespan [21]. The decreased pumping rate in these mutants is caused by a defective mutation [22], meaning that the feeding decrease is not voluntary. However, it has been shown that the animals' satiety can also affect the pumping rate, as it decreases after feeding [23].…”

Section: Discussionsupporting

confidence: 82%

Association of Euterpe oleracea, Bixa orellana, Myciaria dubia, and Astrocaryum aculeatum (the Terasen® Nutraceutical) Increases the Lifespan of Caenorhabditis elegans

de Melo,

Tavares,

Colares

et al. 2023

JAL

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Aging is a complex process associated with tissue degeneration and an increased risk of age-related diseases. This study aimed to evaluate the impact of Terasen®, a nutraceutical containing standardized extracts of Euterpe oleracea, Myrciaria dubia, and purified oil of Bixa orellana and Astrocaryum aculeatum on the lifespan of Caenorhabditis elegans. The findings demonstrated that Terasen® exhibited significant radical scavenging in vitro, decreased the feeding behavior of C. elegans without affecting the animals’ final size, increased the eggs laid in a concentration-dependent fashion, although the total progeny was reduced compared to the control, and increased the median and maximum lifespan. These findings suggest that Terasen® may improve the lifespan in C. elegans, warranting further investigation.

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Section: Discussionsupporting

confidence: 82%