Monoliths of Aligned Silica-Polypeptide Hexagonal Platelets

Bellomo, Enrico G.; Deming, Timothy J.

doi:10.1021/ja056227h

Cited by 69 publications

(66 citation statements)

References 27 publications

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“…Oxidation of the cysteine sulfhydryl groups affected the assembly of the block copolypeptide, resulting in various silica morphologies such as silica hard spheres and well-defined columns of amorphous silica. Bellomo and Deming recently reported the formation of monoliths composed of silica-polypeptide hexagonal platelets using a nonionic, a-helical polypeptide in concentrated solutions [169]. The obtained platelets aligned normal to an applied magnetic field, yielding long-range order in the monoliths.…”

Section: Immobilization Of Other Biopolymers On Mesoporous Materialsmentioning

confidence: 99%

Immobilization of Biomolecules on Mesoporous Structured Materials

Vinu

Gokulakrishnan

Mori

et al. 2007

Bio‐inorganic Hybrid Nanomaterials

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Various functional systems have been developed using artificially constructed structures and synthesized compounds, and the nanotechnology based on them has recently received much attention. However, current nanoscale technologies are still highly inferior to those seen in natural systems. The efficiency of the energy conversion that occurs in mitochondrial and photosynthetic systems far exceeds that obtained in artificial systems. A dog can smell and a bat can hear far more sensitively than most artificial sensors. The information processing exhibited by the brain and nervous systems is much more sophisticated than that exhibited by current computers. Nature developed superior nanotechnologies to our own several billion years ago. Therefore, the use of biomaterials for the development of various functional systems can be a very practical approach to reaching several goals in current nanotechnologies.Unfortunately, biomolecules in most cases give their best performance under ambient conditions and are not mechanically and thermally strong enough to be used in harsh conditions. In order to overcome such difficulties, hybridization of biomolecules with supporting materials such as lipid assemblies, polymers and inorganic materials has been proposed to attain both biological functions and mechanical stability . Biomolecules are frequently immobilized on silica supports through a sol-gel process. As advanced silica structures, mesoporous silica molecular sieves and related materials have received much attention as inorganic supports for biomolecules [31][32][33][34][35][36][37][38][39][40]. Mesoporous silica materials are chemically and mechanically stable and resistant to microbial attack. In addition, chemical modification to introduce organic functional groups to the inner silica pore wall is highly possible. Outstanding properties of the mesoporous structure also lie in their high specific surface area and huge specific pore volume, which are definitely advantageous for the efficient accommodation of biomolecules. In addition, the narrow pore size distribution could provide reliable immobilization of biomolecules. According to the j113 Bio-inorganic Hybrid Nanomaterials. Edited

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Section: Immobilization Of Other Biopolymers On Mesoporous Materialsmentioning

confidence: 99%

Immobilization of Biomolecules on Mesoporous Structured Materials

Vinu

Gokulakrishnan

Mori

et al. 2007

Bio‐inorganic Hybrid Nanomaterials

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“…As mimics of the biosilicification process a number of polyamines such as poly(phenylene vinylene) [14], poly (allylamine) [15], poly(L-lysine) [16], poly(L-arginine) [17], poly(ethyleneimine) [18,19] and small functional molecules [20,21] have been used for the synthesis of silica of various shapes, including rods [15,22,23], platelets [24][25][26], spheres [15,27] hollow spheres [28] and fibers [29][30][31], from solution. The composition, molecular weight and structure of the polyamines and the buffer conditions used are reported to affect the kinetics of the condensation and precipitation processes [14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

“…The composition, molecular weight and structure of the polyamines and the buffer conditions used are reported to affect the kinetics of the condensation and precipitation processes [14][15][16][17][18][19][20][21][22][23][24][25][26][27]. The mechanism of amine mediated silica formation from solution under ambient conditions of pH and temperature is thought to involve electrostatic interaction between negatively charged particulate silica species and positively charged amine groups [32][33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Tuneable Thickness Silica Films on Solid Surfaces Using Amines and Proteins

Rai

Perry

2009

Silicon

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We report an elegant and simple method to fabricate silica films with controlled thickness and roughness using protein coated solid surfaces as substrates. Bovine serum albumin (BSA) and lysozyme having different inherent charges have been used as model proteins (templates) to fabricate silica films. The formation of silica films was achieved by immobilization of BSA and lysozyme on amine (poly(allylamine) (PAH), poly(ethyleneimine) (PEI) and octadecyl amine (ODA)), coated surfaces, followed by treatment with silica precursors (tetramethoxysilane) under environmentally benign conditions of pH and temperature. BSA adsorbs strongly on hydrophilic surfaces (PAH and PEI coated) via electrostatic interaction, while lysozyme shows greater affinity towards hydrophobic surfaces (ODA coated) via largely hydrophobic interactions. The thickness (12-60 nm) and roughness of the films (1.30-3.75 nm) could be tuned by varying the amount of the adsorbed proteins on the amine-coated surfaces. This simple route to prepare silica films of controlled thickness could have potential application in membrane fabrication, biomedical devices, biosensors and next generation electronic components.

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“…[10,12] However, these processes require to proceed rather slowly in order to retain a controlled silicification reaction. [13] In contrast to the synthetic routes, [8] marine organisms access silicic acid as silica source. Specialized proteins collect silicic acid from low concentrations in the ocean (90 mM), [14] promote their storage and localization as well as catalyze the directed silica condensation.…”

Section: Introductionmentioning

confidence: 99%

High Rate Silicification of Peptide‐Polymer Assemblies Toward Composite Nanotapes

Kessel

Börner

2008

Macromol. Rapid Commun.

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Well‐defined silica composite nanofibers are generated in a silicification process of self‐assembled poly(ethylene oxide)‐peptide nanotapes. Inspired by biological silica morphogenesis processes the nanotapes exhibit strong binding capabilities for silicic acid. Thus, pre‐hydrolyzed tetramethoxysilane could be used as silica precursor. Very low concentrations (270 µM) and short contact times (10 s) are sufficient to form effectively integrated nano‐composite tapes.magnified image

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Monoliths of Aligned Silica-Polypeptide Hexagonal Platelets

Cited by 69 publications

References 27 publications

Immobilization of Biomolecules on Mesoporous Structured Materials

Immobilization of Biomolecules on Mesoporous Structured Materials

Fabrication of Tuneable Thickness Silica Films on Solid Surfaces Using Amines and Proteins

High Rate Silicification of Peptide‐Polymer Assemblies Toward Composite Nanotapes

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