Monolithic methacrylate packed 96-tips for high throughput bioanalysis

The development of a new disposable pipette extraction phase based on polyaniline composites for the determination of levels of antidepressants in plasma samples

“…The advantages of the developed phases include easy preparation and control of permeability and surface charge. monolith phases, frits are not necessary and often result in greater pH stability [18].…”

Novel extraction approach for liquid samples: Stir cake sorptive extraction using monolith

“…As a result, it possesses very good permeability and high surface area. Based on the attractive character, monoliths were also used as the extractive media in some extractive technologies such as SPE [22,23], in-tube SPE [24,25], solid-phase microextraction [26] and SBSE [27]. In our previous study, a serial of new coatings based on Xiaojia Huang Linli Chen Fuhua Lin Dongxing Yuan monoliths for SBSE [27][28][29][30][31][32][33][34][35][36] have been prepared and applied to extract organic pollutants [27][28][29][30][31][32][33][34][35] and inorganic ions [36] in all kinds of matrices.…”

Current Developments and Future Trends in Solid-phase Microextraction Techniques for Pharmaceutical and Biomedical Analyses

“…7,11,[19][20][21][22][23]31,37 2·4 Other flow through equilibrium microextraction techniques Some variations of dynamic flow through equilibrium SPME are based on the configuration of the extraction device, such as a microsyringe (syringe SPME) (Fig. 1E) and pipette tip (in-tip SPME) 47,51,52 (Fig. 1F).…”

“…Furthermore, the in-tip SPME can simultaneously handle 96 samples within 2 min in commercially available systems that use a 96-well format furnished with polymer monolithic tips and a robot. 51,115 Using tips developed in-house, a packed 96-tip assembly was used to successfully extract drugs in human plasma 115 and vitamin D3 in serum. 116 Local anesthetics, anticancer drugs, and β-blockers in human plasma could be also successfully detected by this tip extraction coupled with LC-MS/MS.…”