Monoisoamyl dimercaptosuccinic acid induced changes in pregnant female rats during late gestation and lactation

Mehta, Ashish; Pant, S. C.; Flora, Swaran J.S.

doi:10.1016/j.reprotox.2005.05.008

Cited by 37 publications

(18 citation statements)

References 37 publications

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“…Despite a few drawbacks (copper loss) associated with MiADMSA, the above results suggest that MiADMSA may be a future drug of choice owing to its ability to cross the blood-brain barrier, its lipophilic character, and the absence of any metal redistribution [42,97]. Moderate toxicity observed after repeated MiADMSA administration may be reversible after withdrawal of the chelating agent.…”

Section: Efficacy and Experimental Studiesmentioning

confidence: 87%

“…Flora and Mehta [100] reported that administration of MiADMSA caused no alterations in the heme synthesis pathway except for a slight rise in zinc protoporphyrin levels, suggesting mild anemia. MiADMSA seems to be slightly more toxic in terms of essential metal loss (copper and zinc) and some biochemical alterations in the hepatic tissue in female compared to male rats [42]. However, these effects were temporary and could be reversed following withdrawal of MiADMSA treatment.…”

Section: Drawbacksmentioning

confidence: 90%

“…MiADMSA also does not produce any developmental toxicity in mice in the absence of maternal toxicity [107]. Mehta et al [42] also concluded that MiADMSA had no effect on length of gestation, litter size, sex ratio, viability, and lactation. Taubeneck et al [108] showed that the developmental toxicity of DMSA is mediated mainly through disturbed copper metabolism and this may also be true for MiADMSA.…”

Section: Efficacy and Experimental Studiesmentioning

confidence: 99%

“…BAL therapy should continue until urinary arsenic levels are less than 50 μg/L per Oral administration of MiADMSA was more effective than intraperitoneal administration and the minimum effective dose with least side effects was 50 mg/kg Essential metal loss (copper and zinc) [41,42] 24 hours. Chelation is rarely needed outside the setting of symptomatic acute poisoning.…”

Section: Human Casesmentioning

confidence: 99%

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Medical Countermeasures—Chelation Therapy

Flora¹,

Mittal

Flora

2015

Handbook of Arsenic Toxicology

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Section: Efficacy and Experimental Studiesmentioning

confidence: 87%

Section: Drawbacksmentioning

confidence: 90%

Section: Efficacy and Experimental Studiesmentioning

confidence: 99%

Section: Human Casesmentioning

confidence: 99%

See 2 more Smart Citations

Medical Countermeasures—Chelation Therapy

Flora¹,

Mittal

Flora

2015

Handbook of Arsenic Toxicology

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“…DMSA (meso-2,3-dimercaptosuccinic acid), a dithiol chelator with minimal side effects, was effective in treating chronic arsenic poisoning in animals, but double blinded randomized clinical trials did not yield any beneficial results [5]. Recently, MiADMSA, an isoamyl ester of DMSA, has shown to be more promising than the parental compound [4,[6][7][8][9][10]. Phase I clinical trials for MiADMSA have been approved and their results are awaited.…”

Section: Introductionmentioning

confidence: 99%

Arsenic and the Cardiovascular System

Mehta

Ramachandra

Shim

2015

Handbook of Arsenic Toxicology

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Electrospray Mass Spectrometry of Arsenic Compounds and Thiol–Arsenic Complexes

McKnight‐Whitford

2011

Encyclopedia of Analytical Chemistry

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This article reviews the identification and quantification of arsenic species and their complexes using electrospray ionization mass spectrometry (ESI‐MS). Topics covered include accurate mass determination, select ion monitoring (SIM) and multiple reaction monitoring (MRM), isotopic ratios, common fragmentation patterns, transition ratios, wrong‐way‐round ionization, crosstalk, ion interference, and matrix effects. The analytical methods range from direct‐infusion ESI‐MS and tandem mass spectrometry (MS/MS), to the coupling of the ESI‐MS to high‐performance liquid chromatography (HPLC) separation, and finally to combined analysis using HPLC separation with both inductively coupled plasma mass spectrometry (ICP‐MS) and HPLC/ESI‐MS detections. The combination of both ICP‐MS and ESI‐MS is especially powerful, benefiting from the established, robust, and sensitive element‐specific detection of ICP‐MS, and the molecular detection of ESI‐MS. Using the various mass spectrometry (MS) techniques, a variety of biological and environmental samples have been studied, including the urine of humans and animals, food and plants grown on arsenic‐contaminated soil, surface water, and contaminated groundwater. This article also discusses recent studies on the formation of thiol‐arsenic complexes between select arsenic species and thiols such as glutathione (GSH) and metallothionein (MT). The use of ESI‐MS contributes to determining the stoichiometry and binding location, monitoring the reaction in real time, and evaluating binding constants. Information from binding studies has helped the development of improved ESI‐MS methods through derivatization of arsenic species with thiols.

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Monoisoamyl dimercaptosuccinic acid induced changes in pregnant female rats during late gestation and lactation

Cited by 37 publications

References 37 publications

Medical Countermeasures—Chelation Therapy

Medical Countermeasures—Chelation Therapy

Arsenic and the Cardiovascular System

Electrospray Mass Spectrometry of Arsenic Compounds and Thiol–Arsenic Complexes

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