Monograph: Reassessment of human cancer risk of aldrin/dieldrin

Stevenson, David S.; Walborg, Earl F.; North, D. Warner; Sielken, Robert L.; Ross, Charles E.; Wright, A. N.; Xu, Yong; Kamendulis, Lisa M.; Klaunig, James E.

doi:10.1016/s0378-4274(99)00132-0

Cited by 46 publications

(25 citation statements)

References 194 publications

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“…1A), is accompanied by increased levels of ROS, the depletion of hepatic antioxidant defenses (particularly a-tocopherol), and elevated lipid peroxidation. 22 It was also shown that dieldrin, which is structurally related to aldrin, can induce oxidative stress, resulting in the modulation of gene expression that favors the expansion of latent initiated preneoplastic cells in mouse liver. 22 However, the ''tumor promoter-like'' effects of OCs such as aldrin and dieldrin do not seem to occur in rat, dog, and monkey liver.…”

Section: Prostate Cancermentioning

confidence: 99%

“…22 It was also shown that dieldrin, which is structurally related to aldrin, can induce oxidative stress, resulting in the modulation of gene expression that favors the expansion of latent initiated preneoplastic cells in mouse liver. 22 However, the ''tumor promoter-like'' effects of OCs such as aldrin and dieldrin do not seem to occur in rat, dog, and monkey liver. Thus, because of the inconsistency in the induction of hepatocarcinomas caused by OC exposure in various species, it is unclear whether results from studies in mice can be translated to humans.…”

Section: Prostate Cancermentioning

confidence: 99%

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Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

294

213

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A growing number of well-designed epidemiological and molecular studies provide substantial evidence that the pesticides used in agricultural, commercial, and home and garden applications are associated with excess cancer risk. This risk is associated both with those applying the pesticide and, under some conditions, those who are simply bystanders to the application. In this article, the epidemiological, molecular biology, and toxicological evidence emerging from recent literature assessing the link between specific pesticides and several cancers including prostate cancer, non-Hodgkin lymphoma, leukemia, multiple myeloma, and breast cancer are integrated. Although the review is not exhaustive in its scope or depth, the literature does strongly suggest that the public health problem is real. If we are to avoid the introduction of harmful chemicals into the environment in the future, the integrated efforts of molecular biology, pesticide toxicology, and epidemiology are needed to help identify the human carcinogens and thereby improve our understanding of human carcinogenicity and reduce cancer risk. CA Cancer J Clin 2013;63:120-142.

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Section: Prostate Cancermentioning

confidence: 99%

Section: Prostate Cancermentioning

confidence: 99%

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

294

213

View full text Add to dashboard Cite

show abstract

“…Moreover, the highest percentages of soils with DDT, DDE, Aldrin, and Dieldrin are located near gasoline suppliers and tire services, except for the last, in which Aldrin reached 2.9% and DDE was not detected ( Table 4). The presence of these substances in these locations could be explained by accidental spills during loading and unloading of the compounds; by later residual volatilization, in which the compounds are dispersed through the air currents and can adversely affect human health, especially in workers exposed to the compounds for eight or more hours in areas where these chemicals are bought and sold 6,29,30,31) ; and by evaporation 6,9) ; but not by dermal contact with bare contaminated soils 6) , although cancer risks due to exposure to Aldrin and Dieldrin are still under discussion the EPA classifies them as category B2 human carcinogenic agents 32) .…”

Section: Origin Of Total Hydrocarbons and Pesticides In Chillán And Cmentioning

confidence: 99%

Hydrocarbons and Organochlorine Pesticides in Soils of the Urban Ecosystem of Chillán and Chillán Viejo, Chile

Henríquez¹,

Becerra²,

Barra³

et al. 2006

J. Chil. Chem. Soc.

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Although traditional soil use in Chillán and Chillán Viejo is agricultural, both cities have seen their surrounding areas expand and change drastically. Economic activities have increased, including phytosanitary companies and petroleum derivatives used in agriculture and transport. This has had a large impact on the soil.The present work studies total hydrocarbon contamination (lineal and polycyclic aromatics) and chlorine pesticides (Aldrin, Dieldrin, DDT, and DDE) in surface soils near potential sources of pollution.The concentration of total hydrocarbons in the majority of the samples analyzed is between 0.1 and 70 mg/kg. Only 8.8 % exceed 70 mg/kg., indicating the need for recovery before use, according international regulations.The pesticide Aldrin was found in 41.2 % of the soil samples, DDT in 32.4 %, Dieldrin in 29.4%, and DDE in 2.9%. These levels exceed the maximum limits established for ecological improvement in Chile. Amongst themselves, total hydrocarbons correlated with total pesticides and with DDT, but not with Aldrin or Dieldrin. Correlations were also found for total pesticides with DDT and Aldrin, and strong correlations were observed for DDT with Aldrin, and Aldrin with Dieldrin.

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“…Dieldrin, another dreaded POP insecticide, is associated with non-mutagenic carcinogenesis in mouse but lack of human evidence makes it most probable human carcinogen (Stevenson et al, 1999) Triazophos and Dichlorovos are organophosphate pesticides that are used for agricultural purposes in most of the countries in the world. No information is available on the reproductive, developmental, or carcinogenic effects of dichlorovos on humans.…”

Section: Box Ii: Epigenetics -Clinical Applicationsmentioning

confidence: 99%

Identifying Epigenetic Endpoints of Pesticide Exposure Can Curtail Risk to Develop Cancer: A Review.

Das¹,

Thakur²,

Shrivastava³

et al. 2017

IJAR

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Monograph: Reassessment of human cancer risk of aldrin/dieldrin

Cited by 46 publications

References 194 publications

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Hydrocarbons and Organochlorine Pesticides in Soils of the Urban Ecosystem of Chillán and Chillán Viejo, Chile

Identifying Epigenetic Endpoints of Pesticide Exposure Can Curtail Risk to Develop Cancer: A Review.

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