“Monogamy” in Primates: Variability, Trends, and Synthesis: Introduction to special issue on Primate Monogamy

Díaz‐Muñoz, Samuel L.; Bales, Karen L.

doi:10.1002/ajp.22463

Cited by 31 publications

(27 citation statements)

References 43 publications

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“…Currently, data examining the impact of exogenous manipulation with OT ligand variants on social behavior are available for marmoset monkeys ( Callithrix spp.). The social and mating systems of marmosets have been characterized variously as socially monogamous, polyandrous, polygynous, and ‘flexible’ (Díaz-Muñoz & Bales 2016). Marmosets express many of the specific individual behavioral traits that are commonly associated with social monogamy (French et al 2017).…”

Section: Do Changes In Ot Structure Correspond To Changes In Social Bmentioning

confidence: 99%

Oxytocin structure and function in New World monkeys: from pharmacology to behavior

Mustoe

Taylor

French

2018

Integrative Zoology

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Oxytocin (OT) is a hypothalamic nonapeptide that mediates a host of physiological and behavioral processes including reproductive physiology and social attachments. While the OT sequence structure is highly conserved among mammals, New World monkeys (NWMs) represent an unusual "hot spot" in OT structure variability among mammals. At least 6 distinct OT ligand variants among NWMs exist, yet it is currently unclear whether these evolved structural changes result in meaningful functional consequences. NWMs offer a new area to explore how these modifications to OT and its canonical G-protein coupled OT receptor (OTR) may mediate specific cellular, physiological and behavioral outcomes. In this review, we highlight relationships between OT ligand and OTR structural variability, specifically examining coevolution between OT ligands, OTRs, and physiological and behavioral phenotypes across NWMs. We consider whether these evolved modifications to the OT structure alter pharmacological profiles at human and marmoset OTRs, including changes to receptor binding, intracellular signaling and receptor internalization. Finally, we evaluate whether exogenous manipulation using OT variants in marmoset monkeys differentially enhance or impair behavioral processes involved in social relationships between pairmates, opposite-sex strangers, and parents and their offspring. Overall, it appears that changes to OT ligands in NWMs result in important changes ranging from cellular signaling to broad measures of social behavior.

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Section: Do Changes In Ot Structure Correspond To Changes In Social Bmentioning

confidence: 99%

Oxytocin structure and function in New World monkeys: from pharmacology to behavior

Mustoe

Taylor

French

2018

Integrative Zoology

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“…The high level of social monogamy found among NWM is a topic that has received recent attention and debate. Researchers have argued for the use of more nuanced definitions and classification of social systems in primates (Díaz-Muñoz and Bales, 2016), and this is especially important given that there is considerable variability in sociosexual and parental behavior both between and within species (Díaz-Muñoz, 2016). …”

Section: Neuropeptide Diversity and Social Behavior In New World Mmentioning

confidence: 99%

“…Furthermore, in some cases callitrichines are also polyandrous or polygynous (Dietz and Baker, 1993; Goldizen, 1988; Nievergelt, 2000; Saltzman et al, 2009). Other NWM such as titi and owl monkeys show similar patterns of behavior, but exhibit less extra-pair interactions and hence are ‘more’ socially monogamous than most callitrichines (Díaz-Muñoz and Bales, 2016; Fernandez-Duque, 2007; Spence-Aizenberg et al, 2015). Squirrel monkeys and capuchins, conversely, exhibit non-monogamous social systems.…”

Section: Neuropeptide Diversity and Social Behavior In New World Mmentioning

confidence: 99%

Neuropeptide diversity and the regulation of social behavior in New World primates

French

Taylor

Mustoe

et al. 2016

Frontiers in Neuroendocrinology

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Oxytocin (OT) and vasopressin (AVP) are important hypothalamic neuropeptides that regulate peripheral physiology, and have emerged as important modulators of brain function, particularly in the social realm. OT structure and the genes that ultimately determine structure are highly conserved among diverse eutherian mammals, but recent discoveries have identified surprising variability in OT and peptide structure in New World monkeys (NWM), with five new OT variants identified to date. This review explores these new findings in light of comparative OT/AVP ligand evolution, documents coevolutionary changes in the oxytocin and vasopressin receptors (OTR and V1aR), and highlights the distribution of neuropeptidergic neurons and receptors in the primate brain. Finally, the behavioral consequences of OT and AVP in regulating NWM sociality are summarized, demonstrating important neuromodulatory effects of these compounds and OT ligand-specific influences in certain social domains.

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“…Social monogamy is displayed by a small minority of mammals, usually estimated at 3–5% of mammalian species (Kleiman, 1977; Lukas and Clutton-Brock, 2013; Diaz-Munoz and Bales, 2016; Tecot et al, 2016). In socially monogamous animals, the development of an adult attachment relationship or “pair bond” is associated with the onset of mate-guarding in both males and females (Mason, 1966; Winslow et al, 1993; McGuire and Getz, 1998; Fernandez-Duque et al, 2000; Bowler et al, 2002; Getz et al, 2003; Fisher-Phelps et al, 2016; Tabbaa et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Imaging, Behavior and Endocrine Analysis of “Jealousy” in a Monogamous Primate

et al. 2017

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Understanding the neurobiology of social bonding in non-human primates is a critical step in understanding the evolution of monogamy, as well as understanding the neural substrates for emotion and behavior. Coppery titi monkeys (Callicebus cupreus) form strong pair bonds, characterized by selective preference for their pair mate, mate-guarding, physiological and behavioral agitation upon separation, and social buffering. Mate-guarding, or the “maintenance” phase of pair bonding, is relatively under-studied in primates. In the current study, we used functional imaging to examine how male titi monkeys viewing their pair mate in close proximity to a stranger male would change regional cerebral glucose metabolism. We predicted that this situation would challenge the pair bond and induce “jealousy” in the males. Animals were injected with [18F]-fluorodeoxyglucose (FDG), returned to their cage for 30 min of conscious uptake, placed under anesthesia, and then scanned for 1 hour on a microPET P4 scanner. During the FDG uptake, males (n=8) had a view of either their female pair mate next to a stranger male (“jealousy” condition) or a stranger female next to a stranger male (control condition). Blood and cerebrospinal fluid samples were collected and assayed for testosterone, cortisol, oxytocin, and vasopressin. Positron emission tomography (PET) was co-registered with structural magnetic resonance imaging (MRI), and region of interest analysis was carried out. Bayesian multivariate multilevel analyses found that the right lateral septum (Pr(b>0)=93%), left posterior cingulate cortex (Pr(b>0)=99%), and left anterior cingulate (Pr(b>0)=96%) showed higher FDG uptake in the jealousy condition compared to the control condition, while the right medial amygdala (Pr(b>0)=85%) showed lower FDG uptake. Plasma testosterone and cortisol concentrations were higher during the jealousy condition. During the jealousy condition, duration of time spent looking across at the pair mate next to a stranger male was associated with higher plasma cortisol concentrations. The lateral septum has been shown to be involved in mate-guarding and mating-induced aggression in monogamous rodents, while the cingulate cortex has been linked to territoriality. These neural and physiological changes may underpin the emotion of jealousy, which can act in a monogamous species to preserve the long-term integrity of the pair.

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“Monogamy” in Primates: Variability, Trends, and Synthesis: Introduction to special issue on Primate Monogamy

Cited by 31 publications

References 43 publications

Oxytocin structure and function in New World monkeys: from pharmacology to behavior

Oxytocin structure and function in New World monkeys: from pharmacology to behavior

Neuropeptide diversity and the regulation of social behavior in New World primates

Imaging, Behavior and Endocrine Analysis of “Jealousy” in a Monogamous Primate

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