Monocytic microRNA profile associated with coronary collateral artery function in chronic total occlusion patients

Hakimzadeh, Nazanin; Elias, Joëlle; Wijntjens, Gilbert; Theunissen, Ruud; Weert, Angela van; Smulders, Martijn W.; Akker, Nynke van den; Moerland, Perry D.; Verberne, Hein J.; Hoebers, Loes P.; Henriques, José P.S.; Laan, A.M. van der; İlhan, Mustafa; Post, Mark J.; Bekkers, Sebastiaan C.A.M.; Piek, Jan J.

doi:10.1038/s41598-017-01695-3

Cited by 8 publications

(7 citation statements)

References 34 publications

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“…A detailed description of the patient’s and healthy individual’s characteristics is given in Table 1 . Selection of miRNAs was first conducted by careful in silico analysis, studying the literature for relevant miRs associated with MI 16 , 21 , 22 . We also screened for miRNAs related to cardiovascular pathogenesis including endothelial injury, endothelial activation, and vascular inflammation 21 .…”

Section: Resultsmentioning

confidence: 99%

Identification of microRNAs as potential cellular monocytic biomarkers in the early phase of myocardial infarction: a pilot study

Parahuleva

Euler

Mardini

et al. 2017

Sci Rep

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MicroRNA has been increasingly suggested to be involved in vascular inflammation. The aim of this study was to assess the expression profile of miRs as possible novel cellular biomarkers in circulating monocytes in patients with ST-segment elevation myocardial infarction (STEMI). Microarray techniques and TaqMan polymerase chain reaction were used to analyse the global expression of 352 miRNAs in peripheral blood monocytes from healthy donors (n = 20) and patients (n = 24) with acute STEMI. The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly. During 3.5 ± 1.5 months of follow-up miR-1 and -223 were back to baseline, whereas miR-92a and -99a return to normal levels over 3 months, but remained lower than healthy controls. Furthermore, monocytic expression of miR-143 was positively correlated with hs-CRP (R2 = 0.338; P < 0.031), but not with cTnT. Importantly, treatment of monocytes isolated from healthy individuals with INFγ, but not LPS or TNFα caused an upregulation of miR-143 and downregulation of miR-1. Our findings identify circulating monocytes as putative biomarkers and as novel carriers for the cell-specific transfer of miRs in the early phase of myocardial infarction.

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Section: Resultsmentioning

confidence: 99%

Identification of microRNAs as potential cellular monocytic biomarkers in the early phase of myocardial infarction: a pilot study

Parahuleva

Euler

Mardini

et al. 2017

Sci Rep

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“…Nevertheless, a recent study has found that blood monocytes in patients with developed collateral are remarkably lower than those in patients with poor collateral and an increased lymphocyte/monocyte ratio predicts well‐developed coronary collateral . In chronic occlusion patients, the expression of miRNA339‐5p in monocytes of low collateral capacity patients is significantly decreased . Hence, it may be inferred that monocyte or its relevant factors are the potential markers of good/poor collateral.…”

Section: Discussionmentioning

confidence: 99%

“…61 In chronic occlusion patients, the expression of miRNA339-5p in monocytes of low collateral capacity patients is significantly decreased. 62 Hence, it may be inferred that monocyte or its relevant factors are the potential markers of good/ poor collateral.…”

Section: Con Cluding Remark Smentioning

confidence: 99%

The dynamics of monocytes in the process of collateralization

Liao

Bai

2019

Aging Medicine

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The present treatment for coronary artery disease mainly includes medication and drug therapy combined with coronary revascularization. However, the rate of restenosis after stent implantation is still as high as 10% to 20%, 1 and approximately 20% of patients with coronary artery diffuse multivessel disease are unable to tolerate percutaneous coronary intervention or coronary artery bypass grafting. 2 Then, does any strategy effectively alleviate myocardial ischemic symptoms for those patients? Collateral circulation might be the answer.Many clinical studies show that well-established collateral circulation can effectively protect cardiac muscle from ischemia and improve patients' prognoses. 3 Collateral vessel refers to the tiny anatomical microvessels that bridge the severe stenosis or occlusion between the proximal and distant parts of the same blood vessel or between different blood vessels, with a diameter of 20-350 μm, which can provide blood supply to the ischemic regions and confine myocardial infarct size. 4 Related studies have shown that good collateral circulation plays a role in protecting myocardium from acute myocardial infarction and chronic myocardial ischemia. 5-8 A metaanalysis enrolling 6529 participants from several studies showed that patients with high collateralization had a 36% reduction in death risk compared with patients with low collateralization. 9 Therefore, the establishment of coronary collateral circulation is of great significance for the prognosis of coronary artery disease.The development of collateral circulation refers to the remodeling and enlargement of pre-existing collateral vessels. 10 It is currently believed that when the coronary artery is stenotic or occluded, AbstractCollateralization is an important way for patients with coronary heart disease to supply blood flow to the ischemic area. At present, research on the mechanism of collateral circulation mainly focuses on the inflammatory response. Monocytes are the kernel of inflammatory response during arteriogenesis. Therefore, we reviewed the recent developments in this field in terms of the dynamic changes of monocytes during collateralization. We searched and scanned PubMed for the following terms until November 2018: collateral, collateralization, monocyte, macrophage, and arteriogenesis.Articles were obtained and examined to figure out the dynamics of monocytes in the progress of collateralization. Substantial research shows that recruitment, infiltration, and phenotypic transformation of monocytes can affect function in various ways, respectively. Mechanical or chemical factors that can produce effects on collateral development may be due partly to impact on dynamics of monocytes. Although mechanisms of dynamics of monocytes during arteriogenesis are not elucidated clearly, there is no doubt that deeper exploration of the underlying mechanisms will contribute to pharmaceutical development aiming for promoting collateral development. K E Y W O R D Sarteriogenesis, collateral, collateralization, macrophage, mono...

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“…However, we found that patients with CTO had signi cantly higher risk of recurrent myocardial infarction when compared with those patients without CTO. Therefore, CTO is not only a risk factor for the one-year death of patients with multivessel disease [13][14][15] , but also a risk factor for recurrent myocardial infarction within ve years.…”

Section: Discussionmentioning

confidence: 99%

Clinical study of patients with coronary artery disease combined multivessel disease

Zhu

Wen

Liu³

et al. 2021

Preprint

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Background: To investigate the clinical prognosis of patients with coronary artery disease combined multivessel disease. Methods: The patients who were diagnosed with multivessel disease by coronary angiography were selected in this study. The clinical datas about the clinical prognosis and the incidence of adverse cardiovascular events within five-year follow-up were analyzed. Results: A total of 230 participants were included in this study, includeing 129 male (56.09%) and 101 female (43.91%), the average age was 69.73 ± 10.93. The outcomes showed that the patients with three-vessel lesions had significantly higher rate of diabetes history (51.32% vs. 34.62%, P=0.018), unstable angina pectoris history ( 73.03% vs. 55.13%, P=0.008), and significantly higher risk of cardiogenic mortality (7.24% vs. 1.28%, P=0.045) when compared with patients who had two-vessel lesions. The patients with CTO had significantly higher rate of diabetes history (58.54% vs. 42.86%, P=0.049), unstable angina pectoris history ( 80.49% vs. 64.02%, P=0.029), MI history ( 48.78% vs. 25.40%, P=0.003), significantly lower LVEF (58.73±11.30 vs. 64.23±9.49, P=0.001) and significantly higher risk of recurrent myocardial infarction (12.20% vs. 3.2%, P=0.043) when compared with those patients without CTO. The patients with left main lesions had significantly older age (73.61±9.95 vs. 69.02±10.98, P=0.018) and significantly higher risk of cardiogenic mortality (13.89% vs. 3.61%, P=0.025) when compared with those patients without left main lesions. Conclusions: Among patients with coronary artery disease combined multivessel disease, patients with CTO had significantly lower LVEF and higher risk of recurrent myocardial infarction than patients without CTO. The patients with left main lesions had significantly higher risk of cardiogenic mortality than patients without left main lesions. The patients with three-vessel lesions had higher risk of cardiogenic mortality than patients with two-vessel lesions.

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Monocytic microRNA profile associated with coronary collateral artery function in chronic total occlusion patients

Cited by 8 publications

References 34 publications

Identification of microRNAs as potential cellular monocytic biomarkers in the early phase of myocardial infarction: a pilot study

Identification of microRNAs as potential cellular monocytic biomarkers in the early phase of myocardial infarction: a pilot study

The dynamics of monocytes in the process of collateralization

Clinical study of patients with coronary artery disease combined multivessel disease

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