Clinical study of patients with coronary artery disease combined multivessel disease

Abstract

Background: To investigate the clinical prognosis of patients with coronary artery disease combined multivessel disease. Methods: The patients who were diagnosed with multivessel disease by coronary angiography were selected in this study. The clinical datas about the clinical prognosis and the incidence of adverse cardiovascular events within five-year follow-up were analyzed. Results: A total of 230 participants were included in this study, includeing 129 male (56.09%) and 101 female (43.91%), the average age was 69.73 ± 10.93. The outcomes showed that the patients with three-vessel lesions had significantly higher rate of diabetes history (51.32% vs. 34.62%, P=0.018), unstable angina pectoris history ( 73.03% vs. 55.13%, P=0.008), and significantly higher risk of cardiogenic mortality (7.24% vs. 1.28%, P=0.045) when compared with patients who had two-vessel lesions. The patients with CTO had significantly higher rate of diabetes history (58.54% vs. 42.86%, P=0.049), unstable angina pectoris history ( 80.49% vs. 64.02%, P=0.029), MI history ( 48.78% vs. 25.40%, P=0.003), significantly lower LVEF (58.73±11.30 vs. 64.23±9.49, P=0.001) and significantly higher risk of recurrent myocardial infarction (12.20% vs. 3.2%, P=0.043) when compared with those patients without CTO. The patients with left main lesions had significantly older age (73.61±9.95 vs. 69.02±10.98, P=0.018) and significantly higher risk of cardiogenic mortality (13.89% vs. 3.61%, P=0.025) when compared with those patients without left main lesions. Conclusions: Among patients with coronary artery disease combined multivessel disease, patients with CTO had significantly lower LVEF and higher risk of recurrent myocardial infarction than patients without CTO. The patients with left main lesions had significantly higher risk of cardiogenic mortality than patients without left main lesions. The patients with three-vessel lesions had higher risk of cardiogenic mortality than patients with two-vessel lesions.