Monocyte to high density lipoprotein ratio: a novel inflammation marker related with diabetic retinopathy

Abstract

The most common microvascular complication of diabetes is diabetic retinopathy (DR). A new and recently emerged marker of oxidative stress and inflammation is monocyte to high-density lipoprotein cholesterol ratio (MHR). Platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) have also been shown as they are biomarkers of systemic inflammation in various diseases. The present study aims to assess MHR, its predictive value and relations between other inflammation markers in DR patients. Materials and Methods: Sixty-eight patients with DR, fifty-four DM patients without DR and forty-two control subjects were included in this study. Complete blood count, lipoprotein and uric acid levels were recorded. MHR was calculated. Results: MHR, NLR and PLR were statistically significantly higher in DR group than DM without DR group (p=0.008, p=0.042, p=0.003, respectively). Then, receiver operating characteristic (ROC) curve analysis was performed and pointed that MHR predicted DR using a cutoff level of 0.0156 with 63% sensitivity and 76% specificity. Conclusion: In this study, we investigated MHR in DR patients and its relationship with other inflammatory markers, lipoproteins and uric acid. We suggested that an elevated admission of MHR may be of benefit to detect DR and to determine the CVD risk of these patients.

Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar

“…Recently, MHR has been recognized as a novel biomarker of subclinical inflammation [ 18 , 19 , 20 ]. The total number of monocytes is inversely related to HDL and MHR is reported to be elevated in many disorders such as hypertension [ 21 ], atherosclerosis [ 22 ], and diabetic nephropathy [ 23 ].…”

Uric Acid and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

“…Table 1 presents the characteristics of the 21 eligible studies, including the first author's last name, publication year, region, diabetes type, specimen type, detection method for UA, grouping of each study, sample size of each group, and the NOS score. Accordingly, 16 studies were conducted in Asia ( 22 , 23 , 29 – 32 , 34 – 38 , 40 , 42 – 45 ), and other studies were conducted in Africa ( 28 , 33 , 41 ), Europe ( 39 ), and South America ( 20 ). In addition, two studies were based on type 1 diabetes ( 20 , 39 ) with 2,311 included participants, and the others were based on type 2 diabetes ( 22 , 29 – 38 , 40 , 43 – 45 ) and both types of diabetes ( 23 , 28 , 32 , 41 , 42 ).…”

“…Accordingly, 16 studies were conducted in Asia ( 22 , 23 , 29 – 32 , 34 – 38 , 40 , 42 – 45 ), and other studies were conducted in Africa ( 28 , 33 , 41 ), Europe ( 39 ), and South America ( 20 ). In addition, two studies were based on type 1 diabetes ( 20 , 39 ) with 2,311 included participants, and the others were based on type 2 diabetes ( 22 , 29 – 38 , 40 , 43 – 45 ) and both types of diabetes ( 23 , 28 , 32 , 41 , 42 ). The colorimetric method has been used in most studies to measure UA concentrations, and only one study applied the high-performance liquid chromatography (HPLC) method ( 34 ).…”

Inflammation and Nocturnal Pattern of Blood Pressure in Normotensives

“…SII (calculated as platelet count x neutrophil count / lymphocyte count), NLR, PLR, and MHR were constructed as inflammation-based indexes in accordance with previous studies. [9][10][11][12]15,16…”

“…3,4 In recent years, hematological parameters such as the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR), and systemic immune-inflammation index (SII) have been investigated in different systemic diseases as indicators of inflammation. [5][6][7][8][9][10][11][12] Although studies are searching for…”