Monocyte-to-high-density lipoprotein ratio and systemic inflammation response index are associated with the risk of metabolic disorders and cardiovascular diseases in general rural population

Abstract

BackgroundThe present study aimed to clarify the effects of four inflammatory indicators (monocyte-to-high-density lipoprotein ratio [MHR], neutrophil-to-lymphocyte ratio [NLR], systematic immune-inflammation index [SII], and systemic inflammation response index [SIRI]) in evaluating the risk of metabolic diseases and cardiovascular disease (CVD), filling the gap of inflammation-metabolism system research in epidemiology.MethodsWe conducted a cross-sectional study and multivariable logistic regression analysis to elucidate the association between inflammatory indicators and metabolic diseases and CVD risk. Metabolic diseases were defined as metabolic disorders (MetDs) or their components, such as metabolic syndrome (MetS), dyslipidemia, and central obesity. We calculated the Framingham risk score (FRS) to evaluate 10-year CVD risk.ResultsOdds ratios for the third vs. the first tertile of MHR were 2.653 (95% confidence interval [CI], 2.142–3.286) for MetD, 2.091 (95% CI, 1.620–2.698) for MetS, 1.547 (95% CI, 1.287–1.859) for dyslipidemia, and 1.515 (95% CI, 1.389–1.652) for central obesity. Odds ratios for the third vs. the first tertile of SIRI were 2.092 (95% CI, 1.622–2.699) for MetD, 3.441 (95% CI, 2.917–4.058) for MetS, 1.417 (95% CI, 1.218–1.649) for dyslipidemia, and 2.080 (95% CI, 1.613–2.683) for central obesity. The odds ratio of a 10-year CVD risk of >30% for the third vs. the first tertile of MHR was 4.607 (95% CI, 2.648–8.017) and 3.397 (95% CI, 1.958–5.849) for SIRI.ConclusionsMHR and SIRI had a significant association with MetD and its components, in which a higher level of MHR or SIRI tended to accompany a higher risk of metabolic diseases. Furthermore, they also correlated with CVD, and the increment of these indicators caused a gradually evaluated risk of 10-year CVD risk.

Combination model of neutrophil to high-density lipoprotein ratio and system inflammation response index is more valuable for predicting peripheral arterial disease in type 2 diabetic patients: A cross-sectional study

“…Obtaining the numbers of neutrophils, monocytes, lymphocytes, and platelets is inexpensive and easy via complete blood count, which are altered when an organism is inflamed. Furthermore, new hematological parameters related to HDL-C and complete blood cells, such as NHR ( 8 ), MHR ( 9 ), LHR ( 10 ), PHR ( 11 ), SII ( 12 ), SIRI ( 13 , 14 ), and AISI ( 15 ) have been proposed as novel inflammatory biomarkers.…”

Relationship between SIRI and android and gynoid fat related to obesity and cardiovascular risk: a cross-sectional study of NHANES 2017–2018

“…Wang et al. 12 showed that SIRI is significantly associated with MetS and its components, with a higher SIRI being associated with a higher risk of metabolic disorders. Nicoară et al.…”

“…7–9 Inflammation is directly associated with insulin resistance and chronic metabolic disorders as well as increased cardiovascular risk. 10–12 The adverse combined and superimposed effects of different inflammatory mediators and cytokines on metabolic homeostasis is a critical but difficult issue to address. Obesity is closely related to the inflammatory effects of adipocytes.…”

Established and potential cardiovascular risk factors in metabolic syndrome: Effect of bariatric surgery

“…Other nonlipoprotein biomarkers of metabolic syndrome are summarized in Table 2[83–90,91 ▪ ,92,93–100,101 ▪ ,102,103–107].…”