Combination model of neutrophil to high-density lipoprotein ratio and system inflammation response index is more valuable for predicting peripheral arterial disease in type 2 diabetic patients: A cross-sectional study

Abstract

BackgroundNeutrophil/high-density lipoprotein (HDL) ratio (NHR), monocyte/HDL ratio (MHR), lymphocyte/HDL ratio (LHR), platelet/HDL ratio (PHR), systemic immune-inflammation index (SII), system inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) have been recently investigated as novel inflammatory markers. Herein, the correlation was investigated between these inflammatory biomarkers and peripheral arterial disease (PAD) in type 2 diabetes mellitus (T2DM) patients.MethodsIn this retrospective observational study, the hematological parameter data of 216 T2DM patients without PAD (T2DM-WPAD) and 218 T2DM patients with PAD (T2DM-PAD) at Fontaine stages II, III or IV stage had been collected. Differences in NHR, MHR, LHR, PHR, SII, SIRI, and AISI were analyzed, and receiver operating characteristic (ROC) curves were used to analyze the diagnostic potential of these parameters.ResultsThe levels of NHR, MHR, PHR, SII, SIRI and AISI in T2DM-PAD patients were significantly higher than in T2DM-WPAD patients (P < 0.001). They were correlated with disease severity. Further, multifactorial logistic regression analyses showed that higher NHR, MHR, PHR, SII, SIRI, and AISI might be independent risk factors for T2DM-PAD (P < 0.001). The areas under the curve (AUCs) of the NHR, MHR, PHR, SII, SIRI, and AISI for T2DM-PAD patients was 0.703, 0.685, 0.606, 0.648, 0.711, and 0.670, respectively. The AUC of the NHR and SIRI combined model was 0.733.ConclusionThe levels of NHR, MHR, PHR, SII, SIRI, and AISI were higher in T2DM-PAD patients, and they were independently linked with its clinical severity. The combination model of NHR and SIRI was most valuable for predicting T2DM – PAD.

The impact of wet cupping on haematological and inflammatory parameters in a sample of Jordanian team players

“…Recently, prognostic haematological inflammatory parameters, including the neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR), have been widely described [ [25] , [26] , [27] ]. These parameters are easily measured from CBC indices and provide prognostic values for systemic inflammation [ [25] , [26] , [27] ]. However, no previous study has investigated the impact of cupping on these inflammatory parameters.…”

“…Previous findings implied that cupping therapy is associated with decreased secretion of proinflammatory markers such as interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) [ 31 , 32 ]. The neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) have been recently suggested as diagnostic and prognostic factors for systemic inflammation [ [25] , [26] , [27] ]. NLR is an inflammatory marker and measures the ratio between neutrophil counts (associated with innate immunity) and lymphocyte counts (linked to adaptive immunity) in peripheral blood.…”

Complete Blood Count (CBC)-Derived Inflammation Indexes Are Useful in Predicting Metabolic Syndrome in Adults with Severe Obesity

“…A growing number of studies demonstrated that biomarkers derived from peripheral blood cells, such as the neutrophil to HDL-C ratio [ 27 , 36 , 48 ], monocyte to HDL-C ratio (MHR) [ 32 , 34 , 49 , 50 ], lymphocyte to HDL-C ratio (LHR) [ 27 , 35 , 36 , 37 ], platelet to HDL-C ratio (PHR) [ 27 , 39 , 51 ], System Inflammation Response Index (SIRI) [ 25 , 26 , 31 , 49 , 50 ], Systemic Immune-Inflammation Index (SII) [ 25 , 28 , 31 , 33 ], and Aggregate Index of Systemic Inflammation (AISI) [ 27 , 52 , 53 ], can be used to detect and predict the presence and severity of systemic inflammatory processes, including cardiovascular diseases and MetS.…”

“…In the past few decades, increased levels of inflammatory biomarkers (e.g., Interleukin-6, Tumor Necrosis Factor-alpha, C-reactive protein, the neutrophil to lymphocyte ratio, and the platelet to lymphocyte ratio) have been correlated with both obesity and MetS [ 20 , 21 , 22 , 23 , 24 ]. Furthermore, new hematological parameters related to HDL-C and complete blood cell profiles have been proposed as novel inflammatory biomarkers [ 25 , 26 , 27 , 28 , 29 , 30 ]. These include the monocyte/HDL-C ratio (MHR), lymphocyte/HDL-C ratio (LHR), neutrophil/HDL-C ratio (NHR), platelet/HDL-C ratio (PHR), System Inflammation Response Index (SIRI), Systemic Immune-Inflammation Index (SII), and Aggregate Index of Systemic Inflammation (AISI).…”

Association of neutrophil-to-high-density lipoprotein cholesterol ratio with nonalcoholic fatty liver disease and liver fibrosis: a nationally representative cross-sectional study by NHANES from 2017 to 2020

“…Elevated NHR value is generally considered as an indicator of chronic in ammation and lipid metabolism disorder [19]. There have been several disorders that have been linked to NHR, such as coronary heart disease [20], diabetes [21], mental illness [22], and…”