“…A growing number of studies demonstrated that biomarkers derived from peripheral blood cells, such as the neutrophil to HDL-C ratio [ 27 , 36 , 48 ], monocyte to HDL-C ratio (MHR) [ 32 , 34 , 49 , 50 ], lymphocyte to HDL-C ratio (LHR) [ 27 , 35 , 36 , 37 ], platelet to HDL-C ratio (PHR) [ 27 , 39 , 51 ], System Inflammation Response Index (SIRI) [ 25 , 26 , 31 , 49 , 50 ], Systemic Immune-Inflammation Index (SII) [ 25 , 28 , 31 , 33 ], and Aggregate Index of Systemic Inflammation (AISI) [ 27 , 52 , 53 ], can be used to detect and predict the presence and severity of systemic inflammatory processes, including cardiovascular diseases and MetS.…”