Monocyte imaging after myocardial infarction with 19F MRI at 3 T: a pilot study in explanted porcine hearts

Bönner, Florian; Merx, Marc W.; Klingel, Karin; Begovatz, Paul; Flögel, Ulrich; Sager, Martin; Temme, Sebastian; Jacoby, Christoph; Ravesh, Mona Salehi; Grapentin, Christoph; Schubert, Rolf; Bunke, J.; Roden, Michael; Kelm, Malte; Schrader, Jürgen

doi:10.1093/ehjci/jev008

Cited by 46 publications

(46 citation statements)

References 35 publications

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“…Perfluorocarbon‐containing nanoemulsions are nontoxic and have already been used in the clinic as a blood substitute [27]. We recently demonstrated the feasibility of monocyte imaging with 19 F‐MRI in a pig model of MI in a clinical scanner at 3 Tesla when the nanoemulsions were applied immediately after injury [28]. As discussed above, the time of PFC application after MI is critical for the labeling and imaging of either invading monocytes/macrophages or EPDC.…”

Section: Discussionmentioning

confidence: 99%

Epicardium-Derived Cells Formed After Myocardial Injury Display Phagocytic Activity Permitting In Vivo Labeling and Tracking

Ding

Temme

Quast

et al. 2016

Stem Cells Translational Medicine

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Section: Discussionmentioning

confidence: 99%

Epicardium-Derived Cells Formed After Myocardial Injury Display Phagocytic Activity Permitting In Vivo Labeling and Tracking

Ding

Temme

Quast

et al. 2016

Stem Cells Translational Medicine

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“…A high signal area of delayed enhancement is an irreversible necrotic myocardium. The main reason for myocardial infarction is structural damage of myocardial cells and microvascular damage, and the mechanism underlying the infarction area may be the delay of non-active tissue contrast agents clustered at the entry and exit points, and the distribution volume of the contrast agent in the active and inactive regions (15). …”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging in interventional therapy of patients with acute myocardial infarction prior to and after treatment

Jin

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the study was to investigate the cardiac magnetic resonance (CMR) imaging in interventional therapy of patients with acute myocardial infarction prior to and after treatment. Fifty-six cases of AMI patients with elective treatment by percutaneous coronary intervention (PCI) were continuously selected. Patients with an incidence of 7–10 days were treated with CMR and echocardiography to evaluate the quality of myocardial infarction, visual score method (VSM), wall motion score abnormality, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and left ventricular ejection fraction (LVEF). Patients with an incidence of 10–14 days were treated with PCI, and CMR and echocardiography were evaluated after 6 months, after which the occurrence of major adverse cardiac events (MACE) were compared. The infarction quality, VSM score and wall motion abnormality (WMA) score were significantly reduced following surgery, and the difference was statistically significant (P<0.05). Ultrasound evaluation of LVEDD, LVESD, and LVEF prior to and after surgery was compared, and the difference was not statistically significant (P>0.05). Evaluation of the magnetic resonance imaging (MRI) in LVEDD prior to surgery was increased compared with that of the ultrasound in LVEDD, whereas MRI in LVESD and LVEF was decreased compared to that of the ultrasound obtained for LVESD and LVEF. Additionally, postoperative LVEDD was reduced compared with preoperative LVEDD, whereas LVEF was increased, and the difference was statistically significant (P<0.05). However, the evaluation of LVESD using the two methods exhibited no significant change. MACE occurred in 7 (12.5%) of 56 cases. The infarction quality of patients in the MACE group following surgery indicated that VSM and WMA scores were significantly higher than the group without MACE, while LVEF was lower than the MACE group following surgery, and the difference was statistically significant (P<0.05), albeit the ultrasound results of LVEF indicated no difference. In conclusion, CMR evaluation of AMI patients with elective PCI treatment in myocardial remodeling and cardiac function were more sensitive and accurate than with cardiac ultrasound.

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“…Due to the high imaging sensitivity of USPIO, macrophage recruitment could be clearly detected as a hypointense signal on the T2*WI in our study. Recently, perfluorocarbon nanoemulsion‐based 19 F‐MRI was also used to track and quantify macrophages during inflammation . However, the need for dedicated, high‐performance MRI equipment poses a considerable challenge to the clinical application of this method.…”

Section: Discussionmentioning

confidence: 99%

Monitoring of macrophage recruitment enhanced by Toll‐like receptor 4 activation with MR imaging in nerve injury

Chen

Zhang

et al. 2018

Muscle and Nerve

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Monocyte imaging after myocardial infarction with 19F MRI at 3 T: a pilot study in explanted porcine hearts

Abstract: This pilot study demonstrates that (19)F MRI at 3.0 T with clinically applicable PFOB is feasible, thus highlighting the potential of (19)F MRI to monitor the inflammatory response after AMI.

Cited by 46 publications

References 35 publications

Epicardium-Derived Cells Formed After Myocardial Injury Display Phagocytic Activity Permitting In Vivo Labeling and Tracking

Epicardium-Derived Cells Formed After Myocardial Injury Display Phagocytic Activity Permitting In Vivo Labeling and Tracking

Magnetic resonance imaging in interventional therapy of patients with acute myocardial infarction prior to and after treatment

Monitoring of macrophage recruitment enhanced by Toll‐like receptor 4 activation with MR imaging in nerve injury

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