Monitoring of macrophage recruitment enhanced by Toll‐like receptor 4 activation with MR imaging in nerve injury

Chen, Meiwei; Zhang, Xiang; Lu, Liejing; Fang, Zhang; Duan, Xiaohui; Zheng, Chushan; Chen, Yueyao; Shen, Jun

doi:10.1002/mus.26097

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…Superparamagnetic iron oxide (SPIO) particles, including ultrasmall SPIO particles, are applied for cellular and molecular imaging because of their biocompatibility and ability to generate localized hypointenseT2 and T2 * areas [77,78]. SPIO particles are rapidly phagocytized by macrophages, whose accumulation in nerve undergoing Wallerian degeneration can then be followed from day 1-8 [77] before fading.…”

Section: Nerve Selective Contrast Agentsmentioning

confidence: 99%

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration and regeneration: part 2, non-invasive imaging

et al. 2023

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Peripheral neuroregenerative research and therapeutic options are expanding exponentially. With this expansion comes an increasing need to reliably evaluate and quantify nerve health. Valid and responsive measures of the nerve status are essential for both clinical and research purposes for diagnosis, longitudinal follow-up, and monitoring the impact of any intervention. Furthermore, novel biomarkers can elucidate regenerative mechanisms and open new avenues for research. Without such measures, clinical decision-making is impaired, and research becomes more costly, time-consuming, and sometimes infeasible. Part 1 of this two-part scoping review focused on neurophysiology. In Part 2, we identify and critically examine many current and emerging non-invasive imaging techniques that have the potential to evaluate peripheral nerve health, particularly from the perspective of regenerative therapies and research.

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Section: Nerve Selective Contrast Agentsmentioning

confidence: 99%

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration and regeneration: part 2, non-invasive imaging

et al. 2023

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“…The use of nanotechnology in diagnostics but also in drug delivery and tissue engineering could significantly improve the treatment of patients with injured neuronal tissue [ 386 , 387 , 388 , 389 , 390 ]. Hence, IONP-labelling of stem cells or other cells, such as astrocytes and microglia can be used to track and monitor transplanted cells after implantation, e.g., by a noninvasive imaging modality such as MRI, magnetic particle imaging, positron emission tomography, and multiple photon microscopy [ 391 , 392 , 393 , 394 , 395 , 396 , 397 , 398 , 399 , 400 , 401 , 402 ].…”

Section: Pns and Cns Regenerationmentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

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Molecular imaging of innate immunity and immunotherapy

Xia

Singh

Goel

et al. 2023

Advanced Drug Delivery Reviews

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Monitoring of macrophage recruitment enhanced by Toll‐like receptor 4 activation with MR imaging in nerve injury

Abstract: USPIO-enhanced MRI can be used to monitor the enhanced macrophage recruitment by means of TLR4 signal pathway activation in nerve injury. Muscle Nerve, 2018.

Cited by 5 publications

References 43 publications

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration and regeneration: part 2, non-invasive imaging

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration and regeneration: part 2, non-invasive imaging

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

Molecular imaging of innate immunity and immunotherapy

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