Monocyte/High-Density Lipoprotein Ratio Predicts the Prognosis of Large Artery Atherosclerosis Ischemic Stroke

Li, Youyu; Chen, Daqing; Sun, Laifang; Chen, Zhibo; Quan, Weiwei

doi:10.3389/fneur.2021.769217

Cited by 13 publications

(13 citation statements)

References 54 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MHR is an indicator of atherosclerosis that evaluates inflammation and dyslipidemia [ 21 ]. As reported, the MHR can help to predict ischemic stroke and related complications [ 22 , 23 ] and is also related to extracranial and intracranial atherosclerotic stenosis [ 7 ]. In this study, it was found that there were differences in MHR, lipid, glucose, liver and renal function levels in subjects with different degrees of carotid plaque, suggesting that there were abnormalities in metabolism in people with carotid plaque.…”

Section: Discussionmentioning

confidence: 99%

The blood monocyte to high density lipoprotein cholesterol ratio (MHR) is a possible marker of carotid artery plaque

Men

Nan

et al. 2022

Lipids Health Dis

View full text Add to dashboard Cite

Background MHR is the ratio of monocyte to high-density lipoprotein cholesterol (HDL-C). It has been reported that MHR changes are associated with cardiovascular and cerebrovascular disease. Carotid plaque is a common vascular lesion of the carotid artery and is a manifestation of atherogenesis. This study investigated the relationships between the MHR and the incidence of carotid plaques. Methods The data of 3848 physical examiners were analyzed for retrospective analysis, which included 1428 patients with noncarotid plaque, 1133 patients with single carotid plaque, and 1287 patients with bilateral or multiple carotid plaques. Statistical analysis was performed on SPSS 22.0 0 software and statistical software R and its GAM package. Results The difference was statistically significant in the levels of MHR, body mass index (BMI), high-sensitivity C-reactive protein (hs-CRP), blood lipids (HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (Tg)), blood glucose (Glu), hemoglobin A1c (HbA1c), renal function (urea, creatinine (Crea)), estimated glomerular filtration rate (eGFR), and uric acid (Ua) in the carotid plaque groups (P < 0.001, respectively). There was no significant difference between the sex (P = 0.635) and age (P = 0.063) in the different groups. MHR levels were positively correlated with BMI (r = 0.364, P < 0.001), hs-CRP (r = 0.320, P < 0.001), Tg (r = 0.417, P < 0.001), Crea (r = 0.323, P < 0.001), eGFR (r = − 0.248, P < 0.001), Ua (r = 0.383, P < 0.001) and HbA1c (r = 0.197, P < 0.001). Levels of TC, Glu, and urea were slightly correlated with the MHR level (r = − 0.150, P < 0.001; r = 0.187, P < 0.001; r = 0.137, P < 0.001, respectively). The MHR level increased with elevated severity of carotid plaque in subjects without hypertension or diabetes (P < 0.001). In adjusted models, with the rise of MHR level, the probability of occurrence of carotid plaque had a 1.871-fold (95% CI: 1.015–3.450, P = 0.045) increase; the probability of multiple occurrences of carotid plaques had a 2.896-fold (95% CI: 1.415–5.928, P < 0.001) increase. The GAM curve showed a nonlinear correlation between the normalized MHR and the probability of carotid plaque occurrence. Conclusions MHR could be used as a possible marker for plaque formation and severity.

show abstract

Section: Discussionmentioning

confidence: 99%

The blood monocyte to high density lipoprotein cholesterol ratio (MHR) is a possible marker of carotid artery plaque

Men

Nan

et al. 2022

Lipids Health Dis

View full text Add to dashboard Cite

show abstract

“…According to the Trial of ORG 10172 Acute Stroke Treatment (TOAST) classification, ischemic stroke caused by large artery atherosclerosis (LAA) is a common type of ischemic stroke [ 61 , 62 ]. Li et al [ 53 ] conducted a retrospective study on 316 LAA ischemic stroke patients in order to investigate the relationship between the MHR and the patient’s 3-month functional prognosis. The scientists determined that the group with a poor functional outcome had a higher MHR level than the group with a good functional outcome.…”

Section: Discussionmentioning

confidence: 99%

Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers

Gkantzios

Tsiptsios

Karapepera

et al. 2023

Neurology International

View full text Add to dashboard Cite

Ischemic stroke (IS) exhibits significant heterogeneity in terms of etiology and pathophysiology. Several recent studies highlight the significance of inflammation in the onset and progression of IS. White blood cell subtypes, such as neutrophils and monocytes, participate in the inflammatory response in various ways. On the other hand, high-density lipoproteins (HDL) exhibit substantial anti-inflammatory and antioxidant actions. Consequently, novel inflammatory blood biomarkers have emerged, such as neutrophil to HDL ratio (NHR) and monocyte to HDL ratio (MHR). Literature research of two databases (MEDLINE and Scopus) was conducted to identify all relevant studies published between 1 January 2012 and 30 November 2022 dealing with NHR and MHR as biomarkers for IS prognosis. Only full-text articles published in the English language were included. Thirteen articles have been traced and are included in the present review. Our findings highlight the utility of NHR and MHR as novel stroke prognostic biomarkers, the widespread application, and the calculation of which, along with their inexpensive cost, make their clinical application extremely promising.

show abstract

“…MHR is related with various inflammatory pathologies such as PCOS, multiple sclerosis, and psoriasis [10,23,24]. It is also associated with atherosclerotic diseases such as ischemic stroke, ischemic optic neuropathy and CAD [25,26]. Furthermore, few clinical trials have reported that relationship between MHR and obesity-related diseases such as OSAS, MetS, and NAFLD [8,9,27].…”

Section: Discussionmentioning

confidence: 99%

Monocyte count to high density lipoprotein cholesterol ratio in subjects with overweight and obesity

Kırık¹

2022

Med-Science

View full text Add to dashboard Cite

Monocyte count to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel index that may be a prognostic marker in disorders associated with atherosclerosis and systemic inflammation. There is insufficient data about the role of MHR in increased body weight. We aimed to investigate the relationship of MHR with insulin resistance and other metabolic components in subjects with obesity and overweight. Non-diabetic and normotensive adults who did not use any drugs were included. The study population was allocated into three groups according to body mass index (BMI) as control, overweight, and obesity. The clinical and demographical data were compared between groups and a correlation analysis of MHR with metabolic parameters was performed. A total of 255 subjects (103 men) with obesity (n=107, mean age 40±11 years), overweight (n=99, mean age 39±11 years) and healthy controls (n=49, mean age 36±12 years) were included. MHR values were significantly higher in the obesity (MHR=11.80±5.50; p=0.003) and overweight (MHR =10.70±5.60; p=0.033) groups compared to the controls (MHR=9.10±3.70; 1.39±0.77). MHR was significantly correlated to BMI (r =0.235, p <0.001), waist circumference (r=0.253, p <0.001), homeostasis model assessment of insulin resistance (r=0.187, p=0.003), triglyceride (r=0.294, p<0.001), systolic (r=0.142, p=0.023) and diastolic blood pressure (r=0.149, p=0.017). MHR cutoff for predicting metabolic syndrome (MetS) was 11.0 and the AUC value was 0.707 [(sensitivity: 67%; specificity: 65%), (p<0.001)]. MHR appears to be a practical measure that is significantly associated with obesity and the components of MetS. Future prospective studies are warranted to determine the prognostic role of MHR in the cardiometabolic outcomes of people with obesity.

show abstract

Monocyte/High-Density Lipoprotein Ratio Predicts the Prognosis of Large Artery Atherosclerosis Ischemic Stroke

Cited by 13 publications

References 54 publications

The blood monocyte to high density lipoprotein cholesterol ratio (MHR) is a possible marker of carotid artery plaque

The blood monocyte to high density lipoprotein cholesterol ratio (MHR) is a possible marker of carotid artery plaque

Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers

Monocyte count to high density lipoprotein cholesterol ratio in subjects with overweight and obesity

Contact Info

Product

Resources

About