The blood monocyte to high density lipoprotein cholesterol ratio (MHR) is a possible marker of carotid artery plaque

Xi, Jie; Men, Shasha; Nan, Jingzhu; Yang, Qiuliang; Dong, Jin

doi:10.1186/s12944-022-01741-8

Cited by 12 publications

(14 citation statements)

References 38 publications

(40 reference statements)

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“…Previous studies have evaluated the association between the monocyte-to-HDL-C ratio and cardiovascular mortality, 27 diabetic retinopathy, 28 and carotid plaque. 29 However, the relationship between the monocyte-to-HDL-C ratio and BMD has not been reported. The current study found that the monocyte-to-HDL-C ratio was mainly associated with BMD and osteoporosis in females.…”

Section: Discussionmentioning

confidence: 99%

Association between monocyte to high-density lipoprotein-cholesterol ratio and osteoporosis: An analysis of the National Health and Nutrition Examination Survey 2013–2014

Zhou,

Wu,

Shen

et al. 2023

Journal of Investigative Medicine

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The monocyte to high‐density lipoprotein-cholesterol (HDL-C) ratio (monocyte‐to‐HDL-C ratio) was proposed as a marker of atherosclerosis. Osteoporosis and atherosclerosis share common risk factors and pathophysiological mechanisms. This study aimed to assess the relationship between monocyte‐to‐HDL-C ratio and osteoporosis. Participants aged ≥50 years with complete bone mineral density (BMD), monocyte, and HDL‐C examination data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 were included. Descriptive analysis was performed separately according to males and females. Weight linear regression and weight logistic regression analyses were used to analyze the association between monocyte‐to‐HDL-C ratio and BMD and osteopenia and osteoporosis and vertebral fracture. A total of 1,804 participants were included. Among the participants with osteopenia, 398 (48.31%) were male and 466 (51.91%) were female. Among those with osteoporosis, 38 (2.77%) were male and 95 (9.50%) were female. In females, monocyte‐to‐HDL-C ratio was negatively associated with femoral neck BMD [regression coefficient (β)=-0.18; 95% confidence interval (CI): (-0.29, -0.07)] and high monocyte‐to‐HDL-C ratio was associated with higher odds of osteopenia [odds ratio (OR)=1.22; 95%CI: (1.01, 1.47)] and osteoporosis (OR=1.68; 95%CI: (1.13, 2.49)) after adjusting for confounders. In males, only monocyte‐to‐HDL-C ratio >0.35 was observed to be associated with higher odds of osteoporosis (OR=1.96; 95%CI: (1.02, 3.79)). Stratified analyses showed that similar results were also found in different populations. This study showed that monocyte‐to‐HDL-C ratio was negatively associated with BMD and the risk of osteopenia and osteoporosis in females. The monocyte‐to‐HDL-C ratio may be a new marker of osteoporosis or osteopenia.

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Section: Discussionmentioning

confidence: 99%

Association between monocyte to high-density lipoprotein-cholesterol ratio and osteoporosis: An analysis of the National Health and Nutrition Examination Survey 2013–2014

Zhou,

Wu,

Shen

et al. 2023

Journal of Investigative Medicine

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“…showing that MHR levels increase as carotid plaque severity increases in those without hypertension or diabetes (11). Data related to MHR in stroke have been interpreted mostly on prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…formation and can be used as a possible marker for plaque formation and severity may be relevant in this regard (11).…”

Section: Introductionmentioning

confidence: 99%

İskemik İnmenin Etyolojiye Göre Alt Gruplarında Monosit/Hdl-K Oranlarının Karşılaştırılması

GÜNDÜZ

2023

Genel Tıp Dergisi

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Abstract Background/Aim:The increase in (MHR) values calculated by the ratio of monocyte to high-density lipoprotein cholesterol (HDL-C) is a parameter that has recently been evaluated as a measure of inflammation and oxidative stress.There are data associated with cardiovascular diseases and carotid artery pathologies.The aim of this study is to seek an answer to the question "Can MHR be a guiding parameter in the differentiation of these pathologies that are blamed in the etiology of ischemic stroke?" Methods:The records of 200 patients with the diagnosis of acute ischemic stroke and whose neurological examination, neuroradiological imaging and monocyte and HDL-C examinations were completed within the first 24 hours after the onset of symptoms were evaluated retrospectively. They were grouped according to the TOAST classification.Measured monocyte values, HDL-C values and MHR values obtained by monocyte/HDL-C ratio were analyzed statistically according to TOAST groups, comorbid diseases and gender. Results:There was a statistically significant increase in MHR in male and in diabetics, without any statistically significant difference between TOAST groups in terms of MHR. Conclusion:MHR is not an appropriate parameter to use in the estimation of these groups, as it does not show any difference between the subgroups of stroke depending on the etiology.

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“…A study about the involvement of the Monocytes/HDL-C ratio as a biomarker in carotid artery plaque formation found that the Monocytes/HDL-C ratio positively correlated with body mass index (BMI) as a hallmark in diagnosing obesity and Hb1Ac, therefore representing potential links between T2DM and MetS ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

CRP/HDL–C and Monocyte/HDL-C ratios as Predictors of Metabolic Syndrome in Patients With Type 2 Diabetes Mellitus

Djesevic,

Hasic,

Lepara

et al. 2023

Acta Inform Med

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Background: Metabolic syndrome (MetS) denotes a cluster of co-occurring medical conditions associated with regulating hyperglycemia and acute cardiovascular events and complications. The escalating frequency of MetS among individuals afflicted with type 2 diabetes mellitus (T2DM) underscores its burgeoning significance as a critical public health concern and a complex clinical conundrum. Timely identification is imperative to avert the expedited progression of diabetic complications. Objective: To investigate the role of CRP/HDL-C and Monocyte/HDL ratios in predicting MetS in T2DM individuals. Methods: The study was designed as a two-year prospective study and included 80 T2DM patients divided into MetS and non-MetS groups based on MetS development over two years. The patients’ serums were analyzed for complete blood count parameters, lipid profile, and C-reactive protein (CRP). Based on the laboratory test results, Monocyte/HDL-C and CRP/HDL-C ratios were calculated and analyzed. The receiver operating characteristic (ROC) curve and their corresponding areas under the curve (AUC) were used to determine prognostic accuracy. Results: Monocyte/HDL-C ratio and CRP/HDL-C ratio were significantly higher in MetS-T2DM2 than in nonMetS-T2DM (p=0.003 and p=0.029, respectively). The results of ROC curve analysis have shown that the CRP/HDL-C ratio (AUC of 0.695) and Monocytes/HDL-C ratio (AUC of 0.645) can serve as good predictors of MetS in T2DM patients. Conclusion: This study confirms the reliability of the Monocytes/HDL-C and CRP/HDL-C ratios as novel, simple, low-cost, and valuable predictors of MetS development in T2DM.

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The blood monocyte to high density lipoprotein cholesterol ratio (MHR) is a possible marker of carotid artery plaque

Cited by 12 publications

References 38 publications

Association between monocyte to high-density lipoprotein-cholesterol ratio and osteoporosis: An analysis of the National Health and Nutrition Examination Survey 2013–2014

Association between monocyte to high-density lipoprotein-cholesterol ratio and osteoporosis: An analysis of the National Health and Nutrition Examination Survey 2013–2014

İskemik İnmenin Etyolojiye Göre Alt Gruplarında Monosit/Hdl-K Oranlarının Karşılaştırılması

CRP/HDL–C and Monocyte/HDL-C ratios as Predictors of Metabolic Syndrome in Patients With Type 2 Diabetes Mellitus

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