Monocyte chemotactic protein-1 expression in human preovulatory follicles and ovarian cells

Arıcı, Aydın; Oral, Engin; Bükülmez, Orhan; Buradagunta, Sumati; Bahtiyar, Mert O.; Jones, Ervin E.

doi:10.1016/s0165-0378(97)82476-x

Cited by 64 publications

(47 citation statements)

References 29 publications

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“…There is a preovulatory upregulation of MCP-1 in the rat follicle (15), and it is suggested that MCP-1 regulates macrophage influx into the corpus luteum of the cow during luteolysis (16,17). In the human, the levels of MCP-1 in follicular fluid of IVF cycles were increased by hCG (18). This chemokine has been demonstrated in human ovarian stromal cells (18), and we recently showed that the theca cell compartment of the human follicle is one major source of MCP-1.…”

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confidence: 99%

Monocyte chemotactic protein-1 (MCP-1), its receptor, and macrophages in the perifollicular stroma during the human ovulatory process

Dahm‐Kähler

Ghahremani

Lind

et al. 2009

Fertility and Sterility

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confidence: 99%

Monocyte chemotactic protein-1 (MCP-1), its receptor, and macrophages in the perifollicular stroma during the human ovulatory process

Dahm‐Kähler

Ghahremani

Lind

et al. 2009

Fertility and Sterility

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“…MCP-1 is present in amniotic fluid and extraembriyonic coelom fluid in early pregnancy (Denison et al, 1998). MCP-1 is also normally expressed in the corpus luteum (Tsai et al, 1997) and partially involved in structural and functional luteolysis in humans (Arici et al, 1997), ruminants (Tsai et al, 1997;Townson et al, 2002) and rodents (Bowen et al, 1999). The majority of cells expressing MCP-1 in the corpus luteum are inflammatory cells, including macrophages, which may play a partial role in regression of the corpus luteum since MCP-1 expression in the corpus luteum increases in response to PGF 2α (Haworth et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Elevated Plasma Levels of Interleukin 1β, Tumour Necrosis Factor α and Monocyte Chemotactic Protein 1 Are Associated with Pregnancy Toxaemia in Ewes

2007

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Pregnancy toxaemia is a metabolic disorder that results from an inadequate energy supply to the growing maternal-fetal unit. The mechanism underlying the pathogenesis of the syndrome has not been fully clarified; however, a key role for cytokines and chemokines including interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha) and monocyte chemotactic protein 1 (MCP-1) has been indicated in women and experimental animals. However, information on the maternal plasma levels of IL-1 beta, TNF-alpha and MCP-1 in ewes with pregnancy toxaemia is limited. Thus, the present study was designed to determine plasma IL-1 beta, TNF-alpha and MCP-1 concentrations in ewes with severe (n=6) and mild (n=4) naturally occurring pregnancy toxaemia and in uncomplicated pregnant ewes (n=10) using enzyme-linked immunosorbent assay (ELISA). All ewes with pregnancy toxaemia had significantly lower body temperature and respiratory rate than uncomplicated pregnant ewes (p<0.05). With the highest concentrations in severe cases, heart rate, proteinuria and serum uric acid levels as well as plasma IL-1 beta, TNF-alpha and MCP-1 were significantly different among all three groups (p<0.05). The plasma concentrations of IL-1 beta in control ewes and ewes with mild and severe toxaemia were 15.81 +/- 3.90 pg/ml, 23.83 +/- 2.42 pg/ml and 34.55 +/- 8.03 pg/ml, respectively. The plasma concentrations of TNF-alpha in control ewes and ewes with mild and severe toxaemia were 7.71 +/- 1.61 pg/ml, 16.13 +/- 3.63 pg/ml, and 22.85 +/- 3.64 pg/ml, respectively. The plasma concentrations of MCP-1 in control ewes and ewes with mild and severe toxaemia were 101.70 +/- 9.86 pg/ml, 134.75 +/- 6.24 pg/ml, and 157.67 +/- 9.69 pg/ml, respectively. Moreover, plasma IL-1 beta, TNF-alpha and MCP-1 levels were positively correlated with clinical and well-establish biochemical parameters of pregnancy toxaemia, serum uric acid and proteinuria (p<0.01). Concomitant increase of plasma IL-1 beta, TNF-alpha and MCP-1 concentrations along with serum uric acid, proteinuria, and worsening of the clinical signs indicates that such cytokines are involved in the aetiopathogenesis and in perpetuation of the local and systemic inflammatory reactions in pregnancy toxaemia in ewes. Hence, plasma IL-1 beta, TNF-alpha and MCP-1 may potentially serve as markers to monitor prognosis of pregnancy toxaemia in ewes.

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“…Supporting a relationship between chemokines and sex hormones, MCP-1 secretion has been demonstrated to be involved in follicular development, ovulation, steroidogenesis, and corpus luteum function (24)(25)(26)(27)(28)(29). To date, many studies have investigated MCP-1 levels in the serum (16)(17)(18)(19) and follicular fluid of patients with PCOS (24)(25)(26)(27)(28).…”

mentioning

confidence: 99%

“…To date, many studies have investigated MCP-1 levels in the serum (16)(17)(18)(19) and follicular fluid of patients with PCOS (24)(25)(26)(27)(28). All the previously mentioned studies reported higher MCP-1 levels in patients with PCOS, of whom some indicated a significant correlation between serum LH and MCP-1 levels (17)(18)(19).…”

mentioning

confidence: 99%

Increased monocyte chemoattractant protein-1 levels indicating early vascular damage in lean young PCOS patients

Sönmezer

Özmen

Yarcı

et al. 2011

Fertility and Sterility

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Monocyte chemotactic protein-1 expression in human preovulatory follicles and ovarian cells

Cited by 64 publications

References 29 publications

Monocyte chemotactic protein-1 (MCP-1), its receptor, and macrophages in the perifollicular stroma during the human ovulatory process

Monocyte chemotactic protein-1 (MCP-1), its receptor, and macrophages in the perifollicular stroma during the human ovulatory process

Elevated Plasma Levels of Interleukin 1β, Tumour Necrosis Factor α and Monocyte Chemotactic Protein 1 Are Associated with Pregnancy Toxaemia in Ewes

Increased monocyte chemoattractant protein-1 levels indicating early vascular damage in lean young PCOS patients

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