Increased monocyte chemoattractant protein-1 levels indicating early vascular damage in lean young PCOS patients

Sönmezer, Murat; Özmen, Batuhan; Yarcı, Aslı; Akbıyık, Filiz; Taşçı, Tolga; Aytaç, Ruşen

doi:10.1016/j.fertnstert.2010.08.030

Cited by 14 publications

(14 citation statements)

References 31 publications

(41 reference statements)

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“…Only few studies tested whether chemokine levels were related to PCOS and observed higher levels of MCP-1/CCL2 in these patients [36][37][38]. We found an inverse association between MCP-1/ CCL2 with LH, but not with the other hormones (▶ Tables 1, 2).…”

Section: Continuedmentioning

confidence: 73%

Association between Biomarkers of Low-grade Inflammation and Sex Hormones in Women with Polycystic Ovary Syndrome

Hatziagelaki

Pergialiotis

Kannenberg

et al. 2019

Exp Clin Endocrinol Diabetes

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Objective Women with polycystic ovary syndrome (PCOS) have higher circulating levels of C-reactive protein, but the relationship between inflammation and endocrine function in PCOS remains poorly understood. Thus, this study aimed to investigate the association between low-grade inflammation and sex hormones in women with PCOS. Design and Patients A comprehensive panel of biomarkers of inflammation was measured in serum of 63 women with PCOS using proximity extension assay technology. Associations of 65 biomarkers with sex hormones were assessed without and with adjustment for age and body mass index (BMI). Results In the unadjusted analysis, 20 biomarkers were positively correlated with 17-OH-progesterone (17-OH-P), 14 with prolactin and 6 with free testosterone, whereas inverse associations were found for 16 biomarkers with sex hormone-binding globulin (SHBG), 6 with luteinizing hormone (LH) and 6 with estrogen (all p<0.05). Among the positive associations, correlations were mainly found for five chemokines (CXCL11, CCL4, MCP-4/CCL13, CXCL5, CXCL6) and for VEGF-A, LAP-TGFβ1, TNFSF14 and MMP-1. Inverse associations with sex hormones were mainly present for two chemokines (CXCL1, MCP-2/CCL8), CDCP1, CST5 and CSF-1. Adjustment for age and BMI reduced the number of biomarker associations for SHBG and estrogen, but had hardly any impact on associations with 17-OH-P, prolactin, free testosterone and LH. Conclusion Women with PCOS feature BMI-independent associations between biomarkers of inflammation and certain sex steroid and hypophyseal hormones. Most of these inflammation-related biomarkers were chemokines, which may be relevant as potential mediators of the increased cardiometabolic risk of women with PCOS.

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Section: Continuedmentioning

confidence: 73%

Association between Biomarkers of Low-grade Inflammation and Sex Hormones in Women with Polycystic Ovary Syndrome

Hatziagelaki

Pergialiotis

Kannenberg

et al. 2019

Exp Clin Endocrinol Diabetes

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“…To support the in vitro data, we performed ELISA for the quantitative assay of MCP-1, to demonstrate that the patients with the Mcp-1 polymorphism have increased MCP-1 levels. This profile suggests that they may present a lower degree of chronic inflammation than usually seen in PCOS from other ethnicities [ 37 – 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Only a small case-control study in China has reported that PCOS patients tend to show high Mcp-1 levels, increasing the risk of atherogenesis [ 40 ]. One study conducted in Turkey showed that lean and young PCOS patients have high Mcp-1 levels, which can serve as the early indications of cardiovascular disease and vascular damage [ 37 ]. Furthermore, several studies have also demonstrated that women with PCOS have elevated MCP-1, which was verified in PCOS and control subjects after adjustment for age and body mass index [ 13 , 38 , 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic Variation in the Mcp-1 Gene Promoter Associated with the Risk of Polycystic Ovary Syndrome

Ryoo

Lee

et al. 2015

PLoS ONE

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Monocyte chemoattractant protein-1 (MCP-1) is a pivotal chemokine in the inflammatory response, which plays an important role in recruiting monocytes to sites of injury and infection. However, the exact mechanism of Mcp-1 associated with PCOS risk was unknown. In this study, we explored whether the Mcp-1 -2518G>A polymorphism increases the risk of PCOS. We performed a comparative study of -2518G>A polymorphism of the Mcp-1 gene with PCOS. In addition, luciferase reporter assay was performed to evaluate the Mcp-1 transcriptional activity. A strong association was observed between the -2518G>A polymorphism of Mcp-1 gene and PCOS (p-value = 0.016, odd ratio (OR) = 0.693). A p-value under 0.05 is considered statistically significant. The genotype and allelic frequencies were assumed to be in Hardy-Weinberg equilibrium (HWE). The luciferase assays in 2 cell lines showed that the Mcp-1 -2518G>A substitution can increase the expression of Mcp-1. MCP-1 levels in serum for PCOS group were significantly higher than those in serum for controls (p-value = 0.02). Furthermore, the patients carrying a genotype A/A had significantly increased levels of MCP-1 in serum compared with levels of the MCP-1 of the patients with genotypes G/G and G/A (p-value = 0.031). This is the first study on the genetic variation of the Mcp-1 gene and PCOS. This finding suggests that the Mcp-1 -2518G>A polymorphism is associated with PCOS risk by affecting transcriptional activity, leading to an increased expression level of Mcp-1.

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“…To date, several studies have compared circulating MCP-1 levels between non-PCOS and PCOS patients. [27][28][29][30][31][32][33][34][35][36][37] However, the results published are contradictory. Therefore, in the present study, we performed a meta-analysis to clarify whether circulating MCP-1 levels vary between non-PCOS and PCOS patients.…”

Section: Introductionmentioning

confidence: 99%

Association of circulating monocyte chemoattractant protein‐1 levels with polycystic ovary syndrome: A meta‐analysis

Fang

et al. 2021

American J Rep Immunol

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Problem: Polycystic ovary syndrome (PCOS) is a common hormonal disorder that has a huge impact on the human infertility. Increased levels of various circulating inflammatory cytokines have been observed in PCOS patients, which can contribute to the pathogenesis of PCOS. Monocyte chemoattractant protein-1 (MCP-1), a secretory chemokine, is a potent chemotactic factor that recruits monocytes/macrophages to inflammatory foci. Several previous studies comparing the circulating MCP-1 levels between non-PCOS and PCOS patients have yielded contradictory results. Therefore, the aim of this meta-analysis was to investigate whether circulating MCP-1 levels vary between non-PCOS and PCOS patients. Methods:Research articles published before November 11, 2020, were screened to identify eligible studies. Heterogeneity, sensitivity, and publication bias were analyzed using STATA software. Standardized mean difference (SMD) with a 95% confidence interval (CI) was calculated by the STATA software using a random-effects model.Results: 11 studies were included in this meta-analysis involving 897 individuals: 368 non-PCOS patient and 529 PCOS patients. Our pooled meta-analysis results show that circulating MCP-1 levels were significantly higher in PCOS patients than in non-PCOS patients (SMD = 0.84, 95% CI = [0.37, 1.31], Z = 3.50, p < 0.01). However, due to the limited number of studies included in this meta-analysis, subgroup analysis determined that circulating MCP-1 levels were not significantly varied between obese non-PCOS and obese PCOS patients (SMD = 0.42, 95% CI = [−0.65, 1.49], Z = 0.77, p = 0.442) as well as between non-PCOS and PCOS patients without obesity (SMD = 2.04, 95% CI = [−0.84, 4.93], Z = 1.39, p = 0.166). In addition, circulating MCP-1 levels were also not significantly different between obese and non-obese PCOS patients (SMD = −0.04, 95% CI = [−0.68, 0.60], Z = 0.11, p = 0.909). Conclusion:Our findings reveal that circulating MCP-1 levels are upregulated in women with PCOS and are associated with an increased risk of PCOS.

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Increased monocyte chemoattractant protein-1 levels indicating early vascular damage in lean young PCOS patients

Cited by 14 publications

References 31 publications

Association between Biomarkers of Low-grade Inflammation and Sex Hormones in Women with Polycystic Ovary Syndrome

Association between Biomarkers of Low-grade Inflammation and Sex Hormones in Women with Polycystic Ovary Syndrome

Genetic Variation in the Mcp-1 Gene Promoter Associated with the Risk of Polycystic Ovary Syndrome

Association of circulating monocyte chemoattractant protein‐1 levels with polycystic ovary syndrome: A meta‐analysis

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