Association of circulating monocyte chemoattractant protein‐1 levels with polycystic ovary syndrome: A meta‐analysis

Wu, Ze; Fang, Lanlan; Li, Yuxi; Yang, Yan; Thakur, Avinash; Cheng, Jung‐Chien; Sun, Yingpu

doi:10.1111/aji.13407

Cited by 16 publications

(11 citation statements)

References 51 publications

(150 reference statements)

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“…Previous animal studies showed that C-reactive protein (CRP), white blood cell count (WBC), leukocyte factor 18 (IL-18), leukocyte factor 6 (IL-6), leukocyte factor 1 (IL-1β), monocyte chemotaxis protein-1 (MCP-1), tumor necrosis factor α (TNF-α) and macrophage inflammation protein-lα (MIP-lα) levels were significantly elevated in PCOS rats. Similar abnormalities in these parameters were also demonstrated in the PCOS group compared to the control group after adjustment for patient age and body mass index (BMI) (Cirillo et al, 2019;Bannigida et al, 2020;Rudnicka et al, 2020;Wu et al, 2021).…”

Section: Anti-inflammatory Effects and Nf-κb Inhibitionmentioning

confidence: 62%

Quercetin and polycystic ovary syndrome

Ma¹,

Xiang

Song³

et al. 2022

Front. Pharmacol.

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Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease, and results to opsomenorrhea or amenorrhea, hairy, acne, acanthosis, infertility, abortion. In the long term, PCOS may also increase the risk of endometrial cancer, diabetes, hypertension, dyslipidemia and other diseases. Till now there is no specific drug for PCOS due to the unclearness of the cause and pathogenesis, as current treatments for PCOS only target certain symptoms. Quercetin (QUR) is a flavonoid drug widely found in Chinese herbal medicines, fruits, leaves, vegetables, seeds and plants roots. Studies on other diseases have found that QUR has anti-oxidant, anti-inflammatory, anti-insulin resistance, anti-cancer and other effects. Some studies have shown that serum testosterone (T), luteinizing hormone (LH), the LH/follicule-stimulating hormone (FSH) ratio, fasting glucose, fasting insulin, HOMA-IR and lipid levels are reduced in PCOS patients with QUR treatment. However, the mechanisms of QUR in PCOS patients have not been completely elucidated. In this review, we retrospect the basic characteristics of QUR, and in vitro studies, animal experiments and clinical trials of QUR and plant extracts containing QUR in the treatment of PCOS. We also summarized the effects and mechanism of QUR in ovarian cells in vitro and PCOS model rats, the changes in relevant parameters after QUR administration in PCOS patients, and its potentially therapeutic applications.

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Section: Anti-inflammatory Effects and Nf-κb Inhibitionmentioning

confidence: 62%

Quercetin and polycystic ovary syndrome

Ma¹,

Xiang

Song³

et al. 2022

Front. Pharmacol.

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“…According to some research, elevated MCP-1 mRNA expression has been seen in THP-1 human mononuclear macrophages, which suggests that inflammatory factors are present in PCOS patients' serum (72). As a result, other investigations have found According to a meta-analysis study, PCOS patients have substantially higher levels of MCP-1, which are unrelated to people's BMI (73). In this research, CRP, MCP1, and IL-18 gene expression were found to be significantly higher in the estradiol valerate group compared to the control group, indicating inflammation in mice with PCOS.…”

Section: Discussionmentioning

confidence: 98%

Ameliorative Effect of Chitosan-Propolis Nanoparticles on the Estradiol Valerate -Induced PCOS in Rat

Hosseini¹,

Khodaei²,

Hasansagha³

et al. 2023

Preprint

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Background: Endocrine conditions that impact women define polycystic ovary syndrome. Previous studies have demonstrated a connection between PCOS and insulin intolerance, oxidative stress, and immune system dysfunction. Additionally, some reports have indicated that propolis has antioxidant properties and that chitosan nanoparticles have beneficial effects on the reproductive system. The goal of the present study is to compare metformin (Met) to chitosan-propolis nanoparticles and explain how they protect against a rat PCOS model caused by estradiol valerate (EV). (as a control treatment). Methods: In order to cause PCOS in rodents, a single subcutaneous injection of estradiol valerate was used, followed by a 42-day oral administration of 500 mg/kg of chitosan-propolis nanoparticles. Four sets of rats were created: the control, PCOS, metformin (PCOS and 150 mg/kg metformin), and chitosan-propolis nanoparticle (PCOS and 500 mg/kg chitosan-propolis nanoparticle) groups. The histopathological examination of the ovaries and measurement of serum ferctors were performed on all of the animals. Estradiol valerate caused PCOS, but chitosan-propolis nanoparticle therapy reversed it. Results: After chitosan-propolis nanoparticle intervention, the body weight and ovarian morphology had improved, and the serum biochemical parameters, including esretogen, progestron, vitamin D, calcium, and the insulin resistance index, had been corrected. These EV-induced changes include decreased SOD activity, elevated MDA levels, and evidence that oxidative stress was increased by EV when chitosan-propolis nanoparticle/Met were administered for 42 straight days. Additionally, certain relative mRNA transcripts, including those for the MCP, IL18, and CRP genes, were markedly upregulated in EV-treated animals. These findings unequivocally demonstrate the beneficial effects of chitosan-propolis nanoparticles/Met in inflammatory disorders. Conclustion: Together, the study's end findings, which are presented here, are consistent with the hypothesis that chitosan-propolis nanoparticle/Met offered protective activity against the harmful effects of EV. Although ameliorative effects may have been implicated, the primary pathway or pathways still need to be clarified.

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“…The primary biological function of MCP-1 is to recruit monocytes, neutrophils, and lymphocytes to the effector site to produce an inflammatory response. A recent meta-analysis of 11 studies including 529 PCOS patients showed that the level of MCP-1 was significantly increased in PCOS patients, with no significant difference between obese and non-obese PCOS patients (8). TNF-α is a cytokine produced in the acute phase of the body's inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Relationship between proinflammatory cytokines and clomiphene resistance in patients with polycystic ovary syndrome

Wang¹,

Teng²,

Wu³

et al. 2021

Ann Palliat Med

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Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of childbearing age. We aimed to investigate the correlations between proinflammatory cytokine levels and clomiphene resistance in patients with PCOS.Methods: Between January 2019 and January 2020, a total of 72 PCOS patients who attended our department were administered clomiphene 50-100 mg/day on days 5-9 of the menstrual cycle to induce ovulation. Patients were divided into a clomiphene-sensitive group (n=42) and a clomiphene-resistant group (n=30). The proinflammatory cytokines interleukin-23 (IL-23), monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor α (TNF-α), angiopoietin-2, and adiponectin were measured by an enzyme-linked immunosorbent assay (ELISA). The receiver-operating characteristic curve was employed to determine the capability of various parameters to distinguish clomiphene resistance. The univariate logistic regression analysis was used to analyze the associations between pro-inflammatory cytokine levels and clomiphene resistance in PCOS.Results: Serum IL-23 levels showed no statistically significant difference between the clomiphene-sensitive and the clomiphene-resistant groups, whereas MCP-1, TNF-α, angiopoietin-2, and adiponectin levels were significantly different between the two groups (all P<0.05). Univariate logistic regression analysis indicated that elevated serum TNF-α [odds ratio (OR) =1.88, P<0.001], decreased angiopoietin-2 (OR =0.61, P=0.007), and adiponectin (OR =0.39, P=0.012) levels were significantly associated with clomiphene resistance. The sensitivity of TNF-α and angiopoietin-2 to distinguish clomiphene resistance in patients with PCOS was 100%. Moreover, the diagnostic efficiency of TNF-α and adiponectin in identifying clomiphene resistance was significantly higher than that of MCP-1 and angiopoietin-2 (all P<0.05).Conclusions: Abnormal TNF-α, angiopoietin-2, and adiponectin levels may be associated with clomiphene resistance in PCOS patients. The serum proinflammatory cytokines TNF-α and adiponectin are helpful discriminators of clomiphene resistance in PCOS patients.

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Association of circulating monocyte chemoattractant protein‐1 levels with polycystic ovary syndrome: A meta‐analysis

Cited by 16 publications

References 51 publications

Quercetin and polycystic ovary syndrome

Quercetin and polycystic ovary syndrome

Ameliorative Effect of Chitosan-Propolis Nanoparticles on the Estradiol Valerate -Induced PCOS in Rat

Relationship between proinflammatory cytokines and clomiphene resistance in patients with polycystic ovary syndrome

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