Monocular and binocular end‐points after epiretinal membrane surgery and their correlation to patient‐reported outcomes

Krarup, T; Nisted, Ivan; Christensen, Ulrik; Kiilgaard, Jens Folke; Cour, Morten la

doi:10.1111/aos.14449

Cited by 7 publications

(4 citation statements)

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“…The presence of metamorphopsia as well as decreased visual acuity in ERM patients, negatively affects the visual quality. [19] Kim et al, in their study, in which they included 84 patients with stage 2, 3, and 4 ERM, observed a decrease in visual acuity and an increase in metamorphopsia scores as the ERM stage increased in the preoperative period. [13] They reported that EIFL thickness was correlated with metamorphopsia scores in the preoperative period.…”

Section: Discussionmentioning

confidence: 93%

The effect of ectopic inner foveal layer thickness on metamorphopsia in idiopathic epiretinal membranes

Akmaz

2024

Eur Eye Res

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The objective is to determine the effect of ectopic inner foveal layer (EIFL) thickness on preoperative and postoperative best-corrected visual acuity (BCVA) and metamorphopsia scores in stage 3 epiretinal membranes (ERM). Methods: Thirty eyes of 28 patients were included in the study. All patients underwent uncomplicated vitrectomy and membrane peeling. EIFL, central foveal thickness (CFT), outer nuclear layer (ONL), inner nuclear layer (INL), inner plexiform layer (IPL) thicknesses were measured preoperatively and postoperatively at 3 months using Spectralis spectral-domain optical cohorence tomography. Horizontal line (MH) and vertical line (MV) metamorphopsia scores were calculated using M-CHARTS. Postoperative changes in OCT parameters and visual functions and the correlations between them were analyzed. Results: EIFL thickness, ONL thickness, and CFT were 143.1±19.1 μm, 189.3±48 μm, and 431.7±58 μm preoperatively, respectively. In the postoperative 3 rd month, they were 131.2±17.3 μm, 163.5±45.1 μm, and 388.2±52.6 μm (P=0.004, P=0.001, P=0.001 respectively). BCVA (logMAR: Logarithm of the minimal angle of resolution), MH, and MV scores at the postoperative 3 rd month were significantly lower than their preoperative values (P<0.001 in all three). Preoperative CFT was found to be correlated with preoperative MH and MV (P=0.031, P=0.02, respectively). Preoperative ONL thickness was correlated with MH and MV scores (P=0.049, P=0.014, respectively). Preoperative INL thickness was only positively correlated with the MH score (P=0.004). There was no correlation between preoperative -postoperative OCT parameters and postoperative visual functions. Conclusion: EIFL thickness had no effect on metamorphopsia and BCVA in stage 3 ERM patients. It was thought that the formation of metamorphopsia in these patients might be due to changes in the outer retinal layers.

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Section: Discussionmentioning

confidence: 93%

The effect of ectopic inner foveal layer thickness on metamorphopsia in idiopathic epiretinal membranes

Akmaz

2024

Eur Eye Res

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“…In contrast, studies on MH and branch retinal vein occlusion patients, along with additional research on ERM surgeries, did not find a significant correlation between metamorphopsia severity and stereoacuity. 17,29,32 The stereotests employed in these studies primarily focused on near vision, lacking assessments for distance stereopsis. Our research contributes quantitative evidence supporting the correlation between metamorphopsia and stereopsis impairment across both near and distance vision, indicating that metamorphopsia significantly impacts the ability for depth perception.…”

Section: Discussionmentioning

confidence: 99%

Quantifying the Relationship Between Unilateral Induced Metamorphopsia and Stereopsis Impairment

Xu,

Liu,

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To investigate the relationship between unilateral metamorphopsia, characterized by visual distortions in one eye, and impaired stereopsis. METHODS.Utilizing both near and distance measurements through advanced testing systems, including 4K smartphones and an active shutter three-dimensional system, we simulated varying degrees of unilateral metamorphopsia in 30 healthy young adults aged between 21 and 29 years. Two types of contour-based stereotest symbols, lines and squares, were developed. Distortions were classified into six distinct patterns, each further divided into eight grades of severity. Participants were tasked with identifying visual targets, and their stereothresholds were determined under different conditions of induced distortion. Stereopsis was measured within a range of 2.9 to 1.0 log arcsec, at 0.2 log arcsec intervals. Stereopsis changes under different distortion scenarios were analyzed using the generalized estimating equations, with a sequential Bonferroni adjustment applied for pairwise comparisons. RESULTS.A direct and quantifiable correlation was observed between the severity of metamorphopsia and reductions in stereopsis. As the degree of visual distortion increased, notably in both frequency and amplitude, there was a corresponding decline in stereopsis. This relationship held true in both near and distance measurements of stereopsis. Statistical analyses further reinforced these findings, highlighting a significant detrimental effect of distortion components on stereoacuity. CONCLUSIONS.The findings highlight the clinical significance of understanding the interplay between unilateral metamorphopsia and stereopsis. Early interventions in conditions leading to metamorphopsia might be critical to maintaining optimal stereopsis.

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“…In patients with ERM, not only visual acuity but also functional parameters other than visual acuity including metamorphopsia and aniseikonia are important in terms of quality of vision [17][18][19]. A retrospective study including 60 eyes with stage 3 and 4 ERM observed a significant correlation between EIFL thickness and M-score, suggesting that EIFL might be a good indicator of metamorphopsia [16].…”

Section: Discussionmentioning

confidence: 99%

Influence of postoperative ectopic inner foveal layer on visual function after removal of idiopathic epiretinal membrane

Kim

Bae

et al. 2021

PLoS ONE

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Purpose To investigate the functional and anatomical parameters and their postoperative changes according to the ectopic inner foveal layer (EIFL) staging scheme for idiopathic epiretinal membrane (ERM). Methods In this prospective study, patients with idiopathic ERM underwent pars plana vitrectomy and ERM removal, and were followed-up for 6 months. The associations of EIFL with pre- and postoperative functional and anatomical parameters were analyzed. Results A total of 84 eyes (84 patients) were included: 39 (46.4%), 33 (39.3%), and 12 (14.3%) as EIFL stages 2, 3, and 4, respectively. At 6 months after surgery, the mean best-corrected visual acuity (BCVA) significantly improved in all EIFL stages (P ≤ 0.003); however, metamorphopsia improved only in eyes with EIFL stage 2 (P = 0.039) and 3 (P = 0.011). The aniseikonia and foveal avascular zone (FAZ) area showed no significant postoperative changes in any of the EIFL stages. Both preoperatively and during 6 months after surgery, the EIFL stage showed a significant correlation with BCVA (P ≤ 0.033), metamorphopsia (P ≤ 0.008), central macular thickness (P < 0.001), and FAZ parameters (P ≤ 0.016) at each time point, but not with aniseikonia. Significant correlations of EIFL thickness with BCVA (P = 0.028) and metamorphopsia (P = 0.006) before surgery were not persistent after surgery. Conclusion Both pre- and postoperatively, the staging of EIFL, rather than its thickness, is a simple and adequate surrogate marker for visual acuity and metamorphopsia in eyes with idiopathic ERM.

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Monocular and binocular end‐points after epiretinal membrane surgery and their correlation to patient‐reported outcomes

Cited by 7 publications

References 50 publications

The effect of ectopic inner foveal layer thickness on metamorphopsia in idiopathic epiretinal membranes

The effect of ectopic inner foveal layer thickness on metamorphopsia in idiopathic epiretinal membranes

Quantifying the Relationship Between Unilateral Induced Metamorphopsia and Stereopsis Impairment

Influence of postoperative ectopic inner foveal layer on visual function after removal of idiopathic epiretinal membrane

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