Monoclonal gammopathies and malignancies in patients with chronic urticaria

Karakelides, Martha; Monson, K.L.; Volcheck, Gerald W.; Weiler, Catherine R.

doi:10.1111/j.1365-4632.2006.02982.x

Cited by 19 publications

(10 citation statements)

References 46 publications

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“…The risk of non-Hodgkin lymphoma was greater among the hematologic cancers. Findings derived from the Mayo Clinic's electronic database revealed that the diagnosis of hematologic malignancy was particularly frequent in patients with chronic urticaria and coexisting monoclonal gammopathy of undetermined significance (MGUS) [15]. In the same study [15], patients presenting a new diagnosis of chronic urticaria at an older age ([56 years) were more likely to have underlying MGUS.…”

Section: Epidemiology and Presentation Of The Diseasementioning

confidence: 95%

“…Findings derived from the Mayo Clinic's electronic database revealed that the diagnosis of hematologic malignancy was particularly frequent in patients with chronic urticaria and coexisting monoclonal gammopathy of undetermined significance (MGUS) [15]. In the same study [15], patients presenting a new diagnosis of chronic urticaria at an older age ([56 years) were more likely to have underlying MGUS. A case series of four female patients with occult papillary carcinoma of the thyroid who developed chronic urticaria which subsided after tumor removal seems to suggest a direct relationship between the two entities [16].…”

Section: Epidemiology and Presentation Of The Diseasementioning

confidence: 95%

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Management of Chronic Spontaneous Urticaria in the Elderly

et al. 2015

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The guidelines for the management of urticaria in adults and children have been revised and updated recently. However, there are few data in the literature concerning several aspects of this disease in the elderly (e.g., epidemiology, etiopathogenesis, clinical aspects, association with co-morbidities, efficacy and safety profiles of treatments, and management strategies). This is an obvious deficiency in the data, as this disease causes a deterioration in quality of life, affecting the quality of sleep, everyday life habits and activities, and inducing severe disability. Chronic spontaneous urticaria (CSU) can also be associated with internal, infectious, autoimmune, or neoplastic diseases. It is therefore necessary to pay particular attention to these clinical issues through appropriate clinical examinations. At the same time, the specific features of medications used to treat CSU in the elderly should be carefully evaluated, as its pharmacological treatment raises a number of problems related both to the clinical condition of the patient and to concomitant diseases, as well as to the polypharmacotherapy, which is common in older subjects and may cause safety problems because of the drug interactions. Non-sedating new-generation antihistamines are the mainstay treatment of CSU for the elderly. The efficacy and safety of alternative treatment options have not been assessed in the geriatric population with CSU; corticosteroids and cyclosporine (ciclosporin) should be used by this population with extreme caution. Similarly, there are no data regarding the actual safety profile of the new-generation antihistamines at higher doses than those recommended in elderly patients.

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Section: Epidemiology and Presentation Of The Diseasementioning

confidence: 95%

Section: Epidemiology and Presentation Of The Diseasementioning

confidence: 95%

Management of Chronic Spontaneous Urticaria in the Elderly

et al. 2015

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“…8 Using immunoelectron microscopy studies and immunoblotting, IgM-kappa anti-skin autoantibodies were identified at the dermal-epidermal junction. 11 The presence of anti-skin autoantibodies having the same isotype as the circulating monoclonal component suggests deposition of the monoclonal component in the skin. However, it is questionable that IgM deposits cause the eruption, as some patients lack IgM deposits.…”

Section: Pathogenesis and Etiologymentioning

confidence: 99%

“…11 In classical Schnitzler syndrome, the monoclonal component was overwhelmingly IgM and the light chain was kappa in 90% of cases. However, in 6 recent cases there was a single IgG monoclonal component, with a light chain kappa in 5 cases, and lambda in one.…”

Section: Laboratory Findingsmentioning

confidence: 99%

Schnitzler syndrome with cold-induced urticaria

Kurian

Lee²,

Vadas³

2011

J Dermatol Case Rep

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“…The high fever accompanying the urticarial rash appeared to be of unknown origin, the aching joints did not show any abnormal radiographic signs, and ESR and CRP levels were continuously elevated throughout the disease course. In addition, a nonspecific hepatomegaly as well as increased levels of anti-thyroid autoantibodies are common findings among SS patients [2, 10], while the negative results of other investigations made it possible to rule out those diseases mainly requiring differential diagnosis from SS [2, 3]. …”

Section: Discussionmentioning

confidence: 99%

Schnitzler’s Syndrome: Monoclonal Gammopathy Associated with Chronic Urticaria

Rizzi¹,

Curci²,

Rinaldi³

et al. 2008

Acta Haematol

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Schnitzler’s syndrome (SS) is defined by monoclonal gammopathy and chronic urticaria combined with at least two of the following features: fever, arthralgia or arthritis, bone pain, hepato- and/or splenomegaly, palpable lymph nodes, elevated ESR, and leukocytosis. We report a 49-year-old man with monoclonal IgM gammopathy and a 4-year history of recurrent urticarial rash, unexplained fever and arthralgias. The skin biopsy from an acute lesion revealed perivascular lymphocytic infiltrates consisting of CD4+ and CD8+ T lymphocytes. To our knowledge, this is the first report of an immunophenotypic characterization of skin infiltrates in SS. A lower CD4+/CD8+ ratio of circulating T lymphocytes was also detected. SS usually has a benign course, but in 15% of patients a lymphoproliferative disorder develops.

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Monoclonal gammopathies and malignancies in patients with chronic urticaria

Abstract: Patients with CU younger than 43 years were unlikely to have associated MGUS or malignancy. A higher percentage of patients with CU and MGUS had an associated diagnosis of hematologic malignancy.

Cited by 19 publications

References 46 publications

Management of Chronic Spontaneous Urticaria in the Elderly

Management of Chronic Spontaneous Urticaria in the Elderly

Schnitzler syndrome with cold-induced urticaria

Schnitzler’s Syndrome: Monoclonal Gammopathy Associated with Chronic Urticaria

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