Monoclonal antibody (HNK 1-Leu 7) defined lymphoid cells in the blood of rheumatoid arthritis patients

Fauré, G; Béné, Marie‐Christine; Tamisier, J. N.; Thomas, Premi

doi:10.1002/art.1780260921

Cited by 5 publications

(2 citation statements)

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“…Moreover, the loss and dysfunction of human post-thymic precursor cells in SLE were partially corrected with thymulin administration [49,83]. Several clinical trials for thymulinmediated anti-arthritis and anti-SLE have been undertaken [10,18,75]. The outcome of these studies needs further investigations.…”

Section: Role In Disease Modulationmentioning

confidence: 95%

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Thymulin: An Emerging Anti-Inflammatory Molecule

Haddad¹,

Saadé

Safieh‐Garabedian

2005

CMCAIAA

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Thymulin is a neuroendocrine hormone with immunoregulatory actions. Originally known as 'serum thymic factor' (FTS), thymulin binds to a carrier protein and zinc (Zn2+) to exert its biologic properties. Thymulin, albeit an essential hormone for the T lymphocyte differentiation and the normalization of the ratio of T-helper cells to suppressor cells, accumulating evidence suggests its involvement in inflammations of various etiologies. Recently, thymulin has been shown to have anti-nociceptive effects in hyperalgesia and in pain of neurogenic origin, ostensibly through action on sensory afferents and the release of anti-inflammatory mediators. Given its anti-inflammatory potential, thymulin downregulates the release of inflammatory mediators, such as cytokines and chemokines, upregulates anti-inflammatory factors, such as interleukin (IL)-10, and exerts molecular control via the regulation of transcription factors and mediators. Recent evidence tends to indicate that thymulin can be a therapeutic agent in many inflammatory diseases and in pathological conditions affecting the peripheral and/or the central nervous system. This review discusses current concepts in the antiinflammatory actions of thymulin and correlates this activity with an emerging theme for therapeutic treatment.

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Section: Role In Disease Modulationmentioning

confidence: 95%

“…For instance, T cell subsets alterations responsible for abnormal values of the CD4+/CD8+ immunoregulatory ratio were improved by in vitro incubation of the lymphocytes with synthetic thymulin in RA patients [17,18].…”

Section: Role In Disease Modulationmentioning

confidence: 98%