Monoclonal Antibodies for the Depletion of Specific Subpopulations of Lymphocytes

Waldmann, Herman; Cobbold, Stephen; Qin, Shixin; Benjamin, Richard J.; Nash, Tony; Welsh, J D; Tarnesby, Georgia

doi:10.1002/9780470513484.ch13

Cited by 1 publication

(1 citation statement)

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“…The main target organs of this pathology are the same peripheral organs and secondary lymphoid tissues; therefore, depleting the immune system through radiation, chemotherapy, or drugs seems to be the only possible option to avoid complications and improve graft survival. However, it has been shown that the depletion of memory T cells in bone marrow transplants can cause an increase in graft failure and the recurrence of leukemias and tumors [ 69 , 70 ]. It has now been found in clinical transplant trials that Treg inoculation manipulated by blocking the costimulatory pathway B7-CD28 using CTLA-4 Ig/Fc) or/and CD40-CD40L (using anti- CD154 mAb) demonstrated improved tolerance to transplants and reduced the need for immunosuppression [ 71 ].…”

Section: Treg Cells and Transplantationmentioning

confidence: 99%

Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants

et al. 2022

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Ozone pollution, is a serious health problem worldwide. Repeated exposure to low ozone doses causes a loss of regulation of the oxidation–reduction systems, and also induces a chronic state of oxidative stress. This fact is of special importance for the regulation of different systems including the immune system and the inflammatory response. In addition, the oxidation–reduction balance modulates the homeostasis of these and other complex systems such as metabolism, survival capacity, cell renewal, and brain repair, etc. Likewise, it has been widely demonstrated that in chronic degenerative diseases, an alteration in the oxide-reduction balance is present, and this alteration causes a chronic loss in the regulation of the immune response and the inflammatory process. This is because reactive oxygen species disrupt different signaling pathways. Such pathways are related to the role of regulatory T cells (Treg) in inflammation. This causes an increase in chronic deterioration in the degenerative disease over time. The objective of this review was to study the relationship between environmental ozone pollution, the chronic state of oxidative stress and its effect on Treg cells, which causes the loss of regulation in the inflammatory response as well as the role played by antioxidant systems in various pathologies.

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Section: Treg Cells and Transplantationmentioning

confidence: 99%