Monoclonal antibodies against human immunodeficiency virus (HIV) type 2 core proteins: cross-reactivity with HIV type 1 and simian immunodeficiency virus.

Abstract

Four mouse monoclonal antibodies were developed after immunization with one human immunodeficiency

Generation, characterization and cross-reactivities of monoclonal antibodies against the p24 core protein and the gp130 envelope glycoprotein of HIV-2ben

“…Furthermore, these results confirm the heterogeneity in the SIV group [15] and that there are some SIV isolates, which are more closely related to HIV-2 than to other SIV isolates (SIVmnd and SIVagmTYO1 ). As demonstrated in Table 1 these results are also in line with the homology of the sequence from the recognized epitope (Table 1, underlined sequence).…”

“…It has been reported previously that mAbs against the core protein p24 crossreact with isolates from the immunodeficiency virus groups, HIV-1, HIV-2 and SIV [15]. The mAb XIV DC10 reacted with all HIV-2, HIV-1, and SIV isolates exept SIVmnd.…”

Identification of a Gag Protein Epitope Conserved Among All Four Groups of Primate Immunodeficiency Viruses by Using Monoclonal Antibodies

“…This shows the remarkable diversity of SIVag m isolates (Allan et al, 1991). The cross-reactivity of MAbs against p24 from isolates of the HIV-2/SIVma~ group with SIV~m p24 has been reported (Minassian et al, 1988;Komatsu et al, 1990). The cross-reactivity of MAbs against the matrix protein p17 of different HIV and SIV isolates has also been investigated, but only restricted cross-reactivity was demonstrated (Minassian et al, 1988;Niedrig et al, 1988;Komatsu et al, 1990;Sutjipto et al, 1990).…”

“…1 isolate . A small number of anti-p24 MAbs which cross-react with SIVao m have been produced against other immunodeficiency viruses (Minassian et al, 1988;Komatsu et al, 1990). Consequently, murine MAbs against the SIVagmTgo_ 7 isolate originating from Ethiopia were generated.…”

Characterization of Monoclonal Antibodies that Distinguish Simian Immunodeficiency Virus Isolates from each Other and from Human Immunodeficiency Virus Types 1 and 2

“…Lowenstine et al, 1986) and infected African green monkeys (Ohta et al, 1988), which crossreacted with the major core protein (p24) of HIV-1. In other studies, M A b s to HIV-2 p24 cross-reacted with HIV-1, SIVMAc, SIVAc~ and SIVsM (Minassian et al, 1988;Niedrig et al, 1988). The SIVMAc M A b s described here are much more selective in their reactivity, especially with respect to HIV-1 or HIV-2.…”