Monobutyl phthalate (MBP) induces energy metabolism disturbances in the gills of adult zebrafish (Danio rerio)

Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities

“…Metabolic disruption by EDCs has also been reported in non-mammalian models. In zebrafish ( Danio rerio ), recent studies indicate that TBT (10 and 50 ng/L), bisphenol A (100 μg/L), triclosan (TCS, 200 μg/L), tetrabrominated bisphenol A (TBBPA, 0.5 μmol/L), tris (1,3-dichloroisopropyl) phosphate (TDCIPP, 0.5 μmol/L), benzophenone 3 (BP-3, 0.5 μmol/L), (2-ethylhexyl) phthalate (DEHP, 50 μg/L) and monobutyl phthalate (MBP, 10 mg/L) markedly affect lipid metabolism and energetic metabolic processes in larvae and adult liver ( Lyssimachou et al, 2015 ; Mu et al, 2018 ; Sun et al, 2020 ; Tao et al, 2020 ). A comparative analysis using zebrafish eleutheroembryos exposed to BPA, TBT, PFOS and E2 showed that the yolk sac area of exposed embryos increased in size with increasing concentrations of all tested compounds ( Martínez et al, 2019a ).…”