Monoaminergic neurotransmission is mediating the antidepressant-like effects of  Passiflora edulis  Sims fo.  edulis

Ayres, Adriana S.F.S.J.; Santos, Wilton B.; Junqueira-Ayres, Décio D.; Costa, Geison Modesti; Ramos, Freddy A.; Castellanos, Leonardo; Alves, Jovelina Samara Ferreira; Asth, Laila; Medeiros, Iris Ucella de; Zucolotto, Silvana Maria; Gavioli, Elaine C.

doi:10.1016/j.neulet.2017.09.010

Cited by 18 publications

(14 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(Dhawan et al, 2004). Modern biochemical and pharmacological studies confirmed that the purified components and crude extracts from P. edulis showed a wide range of in vitro and in vivo bioactivities (Chau and Huang, 2005;Nayak and Panda, 2012;Kinoshita et al, 2013;Otify et al, 2015;Panchanathan and Rajendran, 2015;Silva et al, 2015;Dzotam et al, 2016;Zhang et al, 2016;Ayres et al, 2017;He et al, 2017;Goss et al, 2018;Liu et al, 2018;Mota et al, 2018;Panelli et al, 2018). Table 4 shows the biological activities of main compounds isolated from P. edulis.…”

Section: Biological Activitiesmentioning

confidence: 92%

“…Oral administration of the aqueous (300 mg/kg), ethyl acetate (50 mg/kg), and butanol extracts (50 mg/kg) of P. edulis Sims fo edulis reduced the immobility time in the mice forced swimming test, which is similar to nortriptyline and fluoxetine. Particularly, ethyl acetate and butanol extract rich in flavonoids showed preferably the antidepressant effects, and that can be counteracted by p-chlorophenylalanine, a-methyl-DL-tyrosine chloride and sulpiride, suggesting this action is related exclusively to regulate serotonergic and dopaminergic transmission such as 5-HT, catecholamine and D 2 receptor (Ayres et al, 2017).…”

Section: Antidepressant Activitymentioning

confidence: 99%

See 1 more Smart Citation

Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology

et al. 2020

View full text Add to dashboard Cite

Passiflora edulis, also known as passion fruit, is widely distributed in tropical and subtropical areas of the world and becomes popular because of balanced nutrition and health benefits. Currently, more than 110 phytochemical constituents have been found and identified from the different plant parts of P. edulis in which flavonoids and triterpenoids held the biggest share. Various extracts, fruit juice and isolated compounds showed a wide range of health effects and biological activities such as antioxidant, anti-hypertensive, anti-tumor, antidiabetic, hypolipidemic activities, and so forth. Daily consumption of passion fruit at common doses is non-toxic and safe. P. edulis has great potential development and the vast future application for this economically important crop worldwide, and it is in great demand as a fresh product or a formula for food, health care products or medicines. This mini-review aims to provide systematically reorganized information on physiochemical features, nutritional benefits, biological activities, toxicity, and potential applications of leaves, stems, fruits, and peels of P. edulis.

show abstract

Section: Biological Activitiesmentioning

confidence: 92%

Section: Antidepressant Activitymentioning

confidence: 99%

Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The classical drugs used to treat depression cause many side-effects and, therefore, have been associated with poor patient compliance. Thus, new alternatives have constantly been investigated with the purpose of discovering new antidepressants with fewer side effects [2][3][4]. Previous reports have demonstrated the antidepressant potential of extracts of herbal plants, which have been formerly used for other diseases due to their antioxidant properties [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…These species have both medicinal and agronomic relevance. In traditional medicine, its leaf infusions have been used as tranquilizer/sedative in many countries [2,[10][11][12]. Passiflora edulis f. flavicarpa, popularly known as "yellow passion fruit" is largely cultivated in South America, with Brazil being the top world producer [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…In fact, the synthesis of C-glycosyl flavonoids is an exhaustive, expensive, and unsustainable process [32]. For these reasons, investigating the therapeutic application of flavonoid-enriched extract seems to be more promising [2,5,6,12,13]. Therefore, this current study aims to prepare and characterize P. edulis f. flavicarpa extract-loaded Eudragit nanoparticles, whose antidepressant-like effects and biocompatibility were investigated in mice.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In Vivo Antidepressant Effect of Passiflora edulis f. flavicarpa into Cationic Nanoparticles: Improving Bioactivity and Safety

Alves

Silva

et al. 2020

Pharmaceutics

View full text Add to dashboard Cite

A variety of neuroactive flavonoids can be found in the species of the Passiflora genus; however, their difficulty in crossing the blood–brain barrier limits their in vivo neuropharmacological activity. In this study, cationic nanoparticles were developed as a novel nanocarrier for improving the antidepressant activity of Passiflora edulis f. flavicarpa leaf extract. Formulations obtained using Eudragit E PO polymethylmethacrylate copolymer, as polymeric matrix had their physicochemical properties investigated. The analytical content of the flavonoids vicenin-2, orientin, isoorientin, vitexin, and isovitexin was determined in the plant extract. Small-sized and spherical nanoparticles loaded with Passiflora edulis f. flavicarpa were obtained with positive zeta potential and high encapsulation efficiency. In addition, the nanosystems were shown to be stable for at least 6 months. The antidepressant activity of P. edulis extract (50 and 100 mg/kg) as well as the extract-loaded nanoparticles (5 mg/kg) were investigated in mice using the forced swimming test, where the latter increased the potency of the former by 10-fold. In addition, histopathological and biochemical analysis confirmed the biocompatibility of the extract-loaded nanoparticles. This study demonstrated that the Eudragit cationic nanoparticles were able to improve the antidepressant activity of P. edulis in the central nervous system of mice.

show abstract

Preparation and application of holocellulose, cellulose nanofibers, and silver-loaded cellulose nanofibers from passion fruit peel

Chen

Ke²,

Hu³

et al. 2022

Cellulose

View full text Add to dashboard Cite

Monoaminergic neurotransmission is mediating the antidepressant-like effects of Passiflora edulis Sims fo. edulis

Cited by 18 publications

References 27 publications

Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology

Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology

In Vivo Antidepressant Effect of Passiflora edulis f. flavicarpa into Cationic Nanoparticles: Improving Bioactivity and Safety

Preparation and application of holocellulose, cellulose nanofibers, and silver-loaded cellulose nanofibers from passion fruit peel

Contact Info

Product

Resources

About