Monoamine neurotransmitters and mood swings: a dynamical systems approach

Loula, R.; Monteiro, Luiz Henrique Alves

doi:10.3934/mbe.2022187

Cited by 7 publications

(2 citation statements)

References 32 publications

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“…For example, dopamine plays a role in the reward system, motivation, and emotional arousal. Serotonin is associated with mood ( Loula and Monteiro, 2022 ) and peripheral tissues ( Lv and Liu, 2017 ). Neurotransmitters relate to human personality and dispositional traits ( Delvecchio et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Dispositional mindfulness and BIS/BAS up-close: can the self-regulation of people be seen in the eyes?

Valachová

Lisá

2023

Front. Psychol.

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IntroductionPigmentation in animal models is related to behavioral regulation and development, suggesting that both may belong to the same biological system. However, such models are poorly documented in humans. The current study explored personality and group differences in self-regulation among healthy subjects and their specific eye structures (contraction furrows and pigment spots). Three objectives were proposed: to analyze statistical differences in dispositional mindfulness (DM), behavioral inhibition system (BIS), and behavioral approach system (BAS) among subjects with a specific iris type of contraction furrows and pigment spots.MethodsThe study sample consisted of 194 university students. One month after taking photographs of their eyes, the students completed the online scales of DM, BIS, and BAS.ResultsDM was negatively related to pigment spots (rs = −0.193; p < 0.01). Cluster analysis of the iris structures converged at a four-cluster solution. The cluster types 2 (absence of pigment spots and contraction furrows extending 8/10 of iris circle or more) and 3 (one or more pigment spots and contraction furrows extending 8/10 of iris circle or more) significantly differed in DM with a small effect size (F = 3.37; p = 0.021; η2 = 0.051). Participants with contraction furrows (8/10 or more circle extent) and without pigment spots had a significantly higher DM than those with pigment spots. No significant differences existed among the iris types in BIS/BAS.DiscussionFuture research directions are suggested.

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Section: Discussionmentioning

confidence: 99%

Dispositional mindfulness and BIS/BAS up-close: can the self-regulation of people be seen in the eyes?

Valachová

Lisá

2023

Front. Psychol.

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“…Monoamine neurotransmitters, also known as monoamines, are a type of neurotransmitter with a single amino group. They play a crucial role in regulating various brain functions, including behavior, memory, emotions, and learning. − Monoamines includes dopamine, serotonin, epinephrine, and norepinephrine, which are involved in motor control, learning, fear and memory, and the fight or flight response, respectively. Disturbances in their function are thought to cause neurological disorders such as depression, anxiety, and Parkinson’s disease. ,− …”

Section: Introductionmentioning

confidence: 99%

Novel LC-MS/MS Method for Simultaneous Determination of Monoamine Neurotransmitters and Metabolites in Human Samples

Kumar,

Sinha,

Gouda

2024

J. Am. Soc. Mass Spectrom.

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For the simultaneous determination of monoamine neurotransmitters (NTs) like dopamine, serotonin, noradrenaline, and epinephrine, and their metabolites (metanephrine, normetanephrine, 3-methoxytyramine, vanillylmandelic acid, 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindoleacetic acid), a robust liquid chromatography method coupled with tandem mass spectrometry (LC–MS/MS) was introduced as the analytical method. This analytical method proved to be accurate for the simultaneous measurement of the amounts of 11 NTs and their metabolites in biological samples. The method proved to be more efficient and better than the previously reported method in terms of precision, recovery, sample requirement, and extraction procedure. The reported method requires only 100 μL of blood and 200 μL of urine, and the extraction procedure requires acetonitrile precipitation, filtration, drying, and reconstitution in water. The separation of all analytes was performed on an C18 column (4.6 mm × 150 mm and 1.8 μm). A 10 min gradient elution program with a mobile phase consisting of phase A (0.2% formic acid in water) and phase B (methanol) was used. The positive ionization mode was used for the detection of all analytes in multiple reaction monitoring (MRM). The proposed method was validated with an internal standard and yielded lower limits of detection and quantification ranges of 0.0182–0.0797 ng/mL and 0.0553–0.2415 ng/mL, respectively, with a good linearity (R 2) between 0.9959 and 0.9994. The recoveries ranged from 73.37% to 116.63% in blood and from 80.9% to 115.33% in urine. For the NTs and metabolites, the intra- and interday % CV were 0.24–9.36 and 0.85–9.67, respectively. The developed LC–MS/MS method was successfully used for the determination of trace amounts of endogenous compounds in human blood and urine samples.

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The mechanisms of learning and memory impairment caused by nonylphenol: a narrative review based on in vivo and in vitro studies

Rang

Liu

2022

Environ Sci Pollut Res

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Monoamine neurotransmitters and mood swings: a dynamical systems approach

Cited by 7 publications

References 32 publications

Dispositional mindfulness and BIS/BAS up-close: can the self-regulation of people be seen in the eyes?

Dispositional mindfulness and BIS/BAS up-close: can the self-regulation of people be seen in the eyes?

Novel LC-MS/MS Method for Simultaneous Determination of Monoamine Neurotransmitters and Metabolites in Human Samples

The mechanisms of learning and memory impairment caused by nonylphenol: a narrative review based on in vivo and in vitro studies

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