Novel LC-MS/MS Method for Simultaneous Determination of Monoamine Neurotransmitters and Metabolites in Human Samples
Dileshwar Kumar,
Sukesh Narayan Sinha,
Balaji Gouda
Abstract:For the simultaneous determination of monoamine neurotransmitters
(NTs) like dopamine, serotonin, noradrenaline, and epinephrine, and
their metabolites (metanephrine, normetanephrine, 3-methoxytyramine,
vanillylmandelic acid, 3,4-dihydroxyphenylacetic acid, homovanillic
acid, and 5-hydroxyindoleacetic acid), a robust liquid chromatography
method coupled with tandem mass spectrometry (LC–MS/MS) was
introduced as the analytical method. This analytical method proved
to be accurate for the simultaneous measuremen… Show more
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