Mono- and multilayer covered drops as carriers

Grigoriev, D. O.; Miller, R.

doi:10.1016/j.cocis.2008.03.003

Cited by 131 publications

(91 citation statements)

References 91 publications

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“…It also allows improving drug's efficacy, its stability, and better intracellular penetration, owing to their enhanced permeation, specific cell targeting, and long circulation in blood stream. [31][32][33][34][35] We have selected a NIR heptamethine indocyanine dye (i.e., IR-780 iodide) as a model hydrophobic photosensitizer basing mainly upon its excellent optical properties and good photosensitizing attributes. IR-780 indocyanine due to its characteristic excitation (k exc.…”

Section: Introductionmentioning

confidence: 99%

“…27,28 One of the most versatile methods of formation of nanostructured functional coatings on colloidal cores, including the oil one, comprises the sequential adsorption of polyelectrolytes (PEs) called the layer-by-layer (LbL) technique. [29][30][31][32] Among many micellar aggregates and their mediated polymeric systems, biocompatible long-sustained release oil-core polyelectrolyte nanocarriers are used. They are fabricated by the subsequent multilayer adsorption of PE at the micellar structures.…”

Section: Introductionmentioning

confidence: 99%

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Microfluidic platform for photodynamic therapy cytotoxicity analysis of nanoencapsulated indocyanine-type photosensitizers

et al. 2016

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The application of nanotechnology is important to improve research and development of alternative anticancer therapies. In order to accelerate research related to cancer diagnosis and to improve the effectiveness of cancer treatment, various nanomaterials are being tested. The main objective of this work was basic research focused on examination of the mechanism and effectiveness of the introduction of nanoencapsulated photosensitizers to human carcinoma (A549) and normal cells . Newly encapsulated hydrophobic indocyanine-type photosensitizer (i.e., IR-780) was subjected to in vitro studies to determine its release characteristics on a molecular level. The photosensitizers were delivered to carcinoma and normal cells cultured under model conditions using multiwell plates and with the use of the specially designed hybrid (poly(dimethylsiloxane) (PDMS)/ glass) microfluidic system. The specific geometry of our microsystem allows for the examination of intercellular interactions between cells cultured in the microchambers connected with microchannels of precisely defined length. Our microsystem allows investigating various therapeutic procedures (e.g., photodynamic therapy) on monoculture, coculture, and mixed culture, simultaneously, which is very difficult to perform using standard multiwell plates. In addition, we tested the cellular internalization of nanoparticles (differing in size, surface properties) in carcinoma and normal lung cells. We proved that cellular uptake of nanocapsules loaded with cyanine IR-780 in carcinoma cells was more significant than in normal cells. We demonstrated non cytotoxic effect of newly synthesized nanocapsules built with polyelectrolytes (PEs) of opposite surface charges: polyanion-polysodium-4-styrenesulphonate and polycation-poly(diallyldimethyl-ammonium) chloride loaded with cyanine IR-780 on human lung carcinoma and normal cell lines. However, the differences observed in the photocytotoxic effect between two types of tested nanocapsules can result from the type of last PE layer and their different surface charge. V C 2016 AIP Publishing LLC. [http://dx

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microfluidic platform for photodynamic therapy cytotoxicity analysis of nanoencapsulated indocyanine-type photosensitizers

et al. 2016

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“…fatty acids, flavors), (ii) nonpolar surfaces (oil or air), and (iii) other proteins. Whereas, internal hydrophobicity results from globular conformations and is relatively ineffective in bulk protein interactions [Grigoriev & Miller, 2009;Jones & McClements, 2010]. Electrical charge of proteins may be both positive and negative and is driven by both isoelectric point (pI) of protein and pH of solution [Guzey & McClements, 2006].…”

Section: Characteristics Of Multilayered Membrane Componentsmentioning

confidence: 99%

“…Small molecule emulsifiers differ in their values of hydrophilic-lipophilic balance and this enables to prepare mixtures of surfactants exhibiting differentiated thermodynamic surface activity (Table 1). Surfactants are usually more surface--active than proteins because they can pack more efficiently at the oil-water (o-w) interface, therefore competitive adsorption between these two components at the o-w interface may occur [Stauffer, 2001;Bortnowska, 2008;Grigoriev & Miller, 2009;Dickinson, 2011].…”

Section: Characteristics Of Multilayered Membrane Componentsmentioning

confidence: 99%

“…Their inclusion is a prerequisite for the manufacturing of functional foods designed to improve the long-term health and well-being of consumers worldwide [Wackerbarth et al, 2009;McClements & Li, 2010a;Yang & McClements, 2013]. The oil--in-water (o/w) emulsions are very suitable for many practical applications where transfer, delivery and/or controlled release of different active species are needed [Grigoriev & Miller, 2009;McClements & Li, 2010b;Bortnowska, 2012]. For example, the incorporation of lipophilic bioactive components into o/w emulsions may increase compatibility with aqueous environment, retard their chemical degradation as well as enhance their activity Shchukina & Shchukin, 2011].…”

Section: Introductionmentioning

confidence: 99%

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