Mono- and Dimeric Naphthalenones from the Marine-Derived Fungus Leptosphaerulina chartarum 3608

Abstract

Five new naphthalenones, two enantiomers (−)-1 and (+)-1 leptothalenone A, (−)-4,8-dihydroxy-7-(2-hydroxy-ethyl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one ((−)-2), (4S, 10R, 4’S)-leptotha-lenone B (5), (4R, 10S, 4’S)-leptothalenone B (6), and a new isocoumarine, 6-hydroxy-5,8-dimethoxy-3-methyl-1H-isochromen-1-one (4), along with two known compounds (+)-4,8-dihydroxy-7-(2-hydroxy-ethyl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one ((+)-2) and (+)-10-norparvulenone (3) were isolated from the marine-derived fungus Leptosphaerulina chartarum 3608. The structures of new compounds were elucidated by HR-ESIMS, NMR, and ECD analysis. All compounds were evaluated for cytotoxicity and anti-inflammatory activity. Compound 6 showed moderate anti-inflammatory activity by inhibiting the production of nitric oxide (NO) in lipopolysaccharide-stimulated RAW264.7 cells, with an IC50 value of 44.5 μM.

Gut mycobiomes are altered in people with type 2 Diabetes Mellitus and Diabetic Retinopathy

“…Dysregulation in the balance between pro-and anti-inflammatory signaling may significantly worsen diseases [80][81][82][83][84]. We anticipated two distinct differences in the mycobiomes between the normal (healthy control) and the diseased states (T2DM and DR).…”

Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049

“…Marine-derived fungi are important resources of structurally and biologically diverse secondary metabolites in drug discovery [1,2,3,4,5,6]. A series of novel marine natural compounds have been isolated from marine-derived fungi of Aspergillus fumigatus strains, such as E -β- trans -5,8,11-trihydroxybergamot-9-ene and β- trans -2β,5,15-trihydroxybergamot-10-ene [7], diketopiperazines [8,9], indole alkaloids [10], fumigaclavine C [11], fumiquinazoline K [12], and gliotoxin analogues [13].…”

A Review of Anti-Inflammatory Compounds from Marine Fungi, 2000–2018

“…The anti-inflammatory effects of these compounds were attributed to the significant inhibition of the expression of iNOS and COX-2 proteins and the inhibition of mRNA expression of anti-pressure cytokines including TNF- α , IL-1 β , IL-6, and IL-12 [61]. From a marine crinoid collected in Xuwen, Zhanjing City, Guangdong Province, China, fungal strain Leptosphaerulina chartarum 3608, was selected for chemical study [62]. One new secondary metabolite, (4 R ,10 S ,4’ S )-leptothalenone B (107, Figure 18), was discovered in the fungus [62].…”

“…From a marine crinoid collected in Xuwen, Zhanjing City, Guangdong Province, China, fungal strain Leptosphaerulina chartarum 3608, was selected for chemical study [62]. One new secondary metabolite, (4 R ,10 S ,4’ S )-leptothalenone B (107, Figure 18), was discovered in the fungus [62]. It was observed to suppress NO production in LPS-induced RAW264.7 cells, with an IC 50 value of 44.5 µM [62].…”

“…One new secondary metabolite, (4 R ,10 S ,4’ S )-leptothalenone B (107, Figure 18), was discovered in the fungus [62]. It was observed to suppress NO production in LPS-induced RAW264.7 cells, with an IC 50 value of 44.5 µM [62]. A detailed chemical investigation of an in-house marine-derived fungi Phoma sp.…”