A Review of Anti-Inflammatory Compounds from Marine Fungi, 2000–2018

Xu, Jianzhou; Yi, Mengqi; Ding, Lijian; He, Shan

doi:10.3390/md17110636

Cited by 52 publications

(28 citation statements)

References 80 publications

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“…), plants (algae), vertebrates (fish) and seawater itself, have found to yield several bioactive compounds. A literature survey (2000–2018) by Xu et al [31] . reported about 133 anti‐inflammatory compounds from marine fungi with 41.4 % isolated from genus Aspergillus .…”

Section: Resultsmentioning

confidence: 99%

Chemical Investigation of Marine‐Derived Fungus Aspergillus flavipes for Potential Anti‐Inflammatory Agents

Tilvi

Parvatkar

Singh

et al. 2021

Chemistry & Biodiversity

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The marine fungus, Aspergillus flavipes (MTCC 5220), was isolated from the pneumatophore of a mangrove plant Acanthus ilicifolius found in Goa, India. The crude extract of A. flavipes was found to show anti‐inflammatory activity. It blocked interleukin‐6 (IL‐6) and tumor necrosis factor‐α (TNF‐α) production in lipopolysaccharide (LPS)‐activated THP‐1 cells with IC50 of 2.69±0.5 μM and 6.64±0.4 μM, respectively. The chemical investigation led to the isolation of optically inactive 4β‐[(1E)‐propen‐1‐yl]cyclopentane‐1β,2β‐diol (1) along with a new optically active diastereoisomeric compound, 4β‐[(1E)‐propen‐1‐yl]cyclopentane‐1β,2α‐diol (2). In addition, the fungus also produced known compounds (+)‐terrein (3), butyrolactone I (4) and butyrolactone II (5) in high yields. Among these, (+)‐terrein (3) exhibited IL‐6 and TNF‐α inhibition activity with IC50 of 8.5±0.68 μM and 15.76±0.18 μM, respectively, while butyrolactone I (4) exhibited IC50 of 12.03±0.85 μM (IL‐6) and 43.29±0.76 μM (TNF‐α) inhibition activity with low toxicity to host cells in LPS stimulated THP‐1 cells. This is the first report of the isolation and characterization of 4β‐[(1E)‐propen‐1‐yl]cyclopentane‐1β,2α‐diol (2). The structures of all the isolated compounds were elucidated on the basis of extensive detailed NMR spectroscopic data. Anti‐inflammatory activity of the fungi A. flavipes is presented here for the first time, which was due to (+)‐terrein and butyrolactone I, as the major constituents and they can be further explored in the therapeutic area.

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Section: Resultsmentioning

confidence: 99%

Chemical Investigation of Marine‐Derived Fungus Aspergillus flavipes for Potential Anti‐Inflammatory Agents

Tilvi

Parvatkar

Singh

et al. 2021

Chemistry & Biodiversity

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“…There has been a tremendous increase in pharmacological research on anti-inflammatory of marine-derived molecules, and more than 150 anti-inflammatory compounds derived from marine fungi have been reported past two decades [ 37 , 38 ]. The anti-inflammatory compounds are classified into different chemical classes, such as terpenes [ 39 , 40 ], steroids [ 41 ], polyketides [ 15 ], alkaloids [ 42 ], and peptides [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102

et al. 2020

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Two new benzofurans, alternabenzofurans A and B (1 and 2) and two new sesquiterpenoids, alternaterpenoids A and B (3 and 4), along with 18 known polyketides (5−22), were isolated from the marine-derived fungus Alternaria sp. 5102. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-ESIMS, and ECD) and X-ray crystallography, as well as the modified Mosher’s method. Compounds 2, 3, 5, 7, 9–18, and 20–22 exhibited potent anti-inflammatory activity by inhibiting the production of NO in RAW264.7 cells activated by lipopolysaccharide with IC50 values in the range from 1.3 to 41.1 μM. Structure-activity relationships of the secondary metabolites were discussed.

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“…So far, more than 10,000 compounds have been isolated and identified from marine organisms [ 13 ], among which, corals and sponges rank as the most prolific sources. Most previous studies on natural compounds from soft corals have reported anti-inflammatory, analgesic, and anti-neuritis properties [ 14 , 15 ]. Since the efficacy of these compounds in treating acne has not been evaluated well, this study attempted to discover their potential anti-acne activities.…”

Section: Discussionmentioning

confidence: 99%

Anti-Acne Effects of Cembrene Diterpenoids from the Cultured Soft Coral Sinularia flexibilis

et al. 2020

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Acne is a skin disease common in adolescents and increasingly common in the adult population. The major pathologic events of acne vulgaris include increased sebum production, retention hyperkeratosis, carrying commensal skin microbiota, and inflammation. In recent years, more than 10,000 compounds have been isolated and identified from marine organisms. The aim of this study was to discover the potential anti-acne activity of fraction 9 + 10 (SF-E) of Sinularia flexibilis extract and six cembrene diterpenoids. We found that the SF-E significantly reduced Cutibacterium acnes-induced edema in Wistar rat ears. The cembrene diterpenoids including 11-dehydrosinulariolide (SC-2), 3,4:8,11-bisepoxy-7-acetoxycembra-15(17)-en-1,12-olide (SC-7), and sinularin (SC-9) reduced nitric oxide (NO) production with 50% inhibitory concentration of 5.66 ± 0.19, 15.25 ± 0.25, and 3.85 ± 0.25 μM, respectively, and inducible NO synthase expression in RAW 264.7 cells. Moreover, treatment with SC-2, SC-7, and SC-9 significantly suppressed lipopolysaccharide- and heat-killed C. acnes-induced expression of proteins involved in mitogen-activated protein kinase pathway in both RAW 264.7 and HaCaT cells. After treatment with SC-2, SC-7, and SC-9, over-proliferation of HaCaT cells was significantly terminated. In summary, SC-2, SC-7, and SC-9 showed anti-inflammatory effects in RAW 264.7 cells, suggesting that these cembrene diterpenoids obtained from S. flexibilis are natural marine products with potential anti-acne activities.

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A Review of Anti-Inflammatory Compounds from Marine Fungi, 2000–2018

Cited by 52 publications

References 80 publications

Chemical Investigation of Marine‐Derived Fungus Aspergillus flavipes for Potential Anti‐Inflammatory Agents

Chemical Investigation of Marine‐Derived Fungus Aspergillus flavipes for Potential Anti‐Inflammatory Agents

Secondary Metabolites with Nitric Oxide Inhibition from Marine-Derived Fungus Alternaria sp. 5102

Anti-Acne Effects of Cembrene Diterpenoids from the Cultured Soft Coral Sinularia flexibilis

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