Mono- and bis-pyrazolophthalazines: Design, synthesis, cytotoxic activity, DNA/HSA binding and molecular docking studies

Synthesis and antifungal screening of tetramethyl hexahydro-1H-xanthene-1,8(2H)-dione derivatives as potential inhibitors of morphogenesis and biofilm formation inCandida albicans

“…7) of HSA two significant peaks at around 208 nm and 222 nm due to the p-p* and n-p* transitions, respectively, corresponding to the a helix and random coil of HSA. 44 The CD results are expressed in terms of the mean residue ellipticity (MRE) and the a helical content was calculated using the CDNN program version 2.1.0.223. 45,46 The data indicate that in the presence of XD-4 the a-helix conformation of HSA was found to be decreased from 69% to 55%.…”