Introducing a high throughput nanocatalytic method toward the synthesis of some pyrazolo phthalazine derivatives under green conditions utilizing imidazoliume based ionic liquid supported on the silica-coated nanosized perlite as a novel, reusable and eco-friendly nanocatalyst

Moradi, Leila; Sasi, Hamideh Rouhi; Dehghani, Abdulhamid

doi:10.1007/s11164-024-05234-4

Res Chem Intermed

2024

DOI: 10.1007/s11164-024-05234-4

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Introducing a high throughput nanocatalytic method toward the synthesis of some pyrazolo phthalazine derivatives under green conditions utilizing imidazoliume based ionic liquid supported on the silica-coated nanosized perlite as a novel, reusable and eco-friendly nanocatalyst

Leila Moradi,

Hamideh Rouhi Sasi,

Abdulhamid Dehghani

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Cited by 2 publications

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Synthesis of 1, 2-Disubstituted Benzimidazoles at Ambient Temperature Catalyzed by 1-Methylimidazolium Tetraflouroborate ([Hmim] BF_4) and Investigating Their Anti-ovarian Cancer Properties Through Molecular Docking Studies and Calculations

Dehghani,

Delshad,

Ahmadpour

et al. 2024

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An environmentally benign method for the synthesis of 1, 2-disubstituted benzimidazoles by the reaction of aromatic aldehydes and o-phenylenediamines (OPD) in the presence of 1-methylimidazolium tetraflouroborate ([Hmim] BF4) at ambient temperature under green conditions is described. A broad range of structurally diverse benzaldehydes were applied successfully, and corresponding products were obtained in good to excellent yields in very short times. All products were identified by the melting points, 1H and 13C NMR techniques. Furthermore, with the help of computational chemistry and drug design methods, the anti-ovarian cancer properties of these compounds were studied and investigated. All the synthesized compounds bind to an agonist at the active site of the 6LAD protein, which leads to the inactivation of this protein and produces beneficial effects during ovarian cancer treatment. In this study, it was found that these compounds have the potential to become an oral anti-cancer drug.

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Synthesis of 1, 2-Disubstituted Benzimidazoles at Ambient Temperature Catalyzed by 1-Methylimidazolium Tetraflouroborate ([Hmim] BF_4) and Investigating Their Anti-ovarian Cancer Properties Through Molecular Docking Studies and Calculations

Dehghani,

Delshad,

Ahmadpour

et al. 2024

Qeios

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A Novel One-Pot Three-Component Approach to Orthoaminocarbonitrile Tetrahydronaphthalenes Using Triethylamine (Et_3N) as a Highly Efficient and Homogeneous Catalyst Under Mild Conditions and Investigating Its Anti-cancer Properties Through Molecular Docking Studies and Calculations

Dehghani,

Delshad,

Ahmadpour

et al. 2024

Qeios

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An efficient and environmentally friendly method for the one-pot synthesis of ortho-aminocarbonitrile tetrahydronaphthalenes has been developed in the presence of triethylamine (Et3N) as a homogeneous catalyst. The multicomponent reactions of benzaldehydes, cyclohexanone and malononitrile were carried out under mild conditions to obtain some ortho-aminocarbonitrile tetrahydronaphthalene derivatives. A broad range of structurally diverse benzaldehydes were applied successfully, and corresponding products (4A-L) were obtained in good to excellent yields (87-98%) in very short times (10-25 minutes). The present approach provides several advantages including simple workup, high yields, very mild reaction conditions, short reaction times, little catalyst loading and not requiring specialized equipment. Furthermore, with the help of computational chemistry and drug design methods, the anti-cancer properties of these compounds were studied and investigated. All the synthesized compounds bind to an agonist at the active site of the 3A8P protein, which leads to the inactivation of this protein and produces beneficial effects during cancer treatment. In synthesized compounds, the ligands establish hydrogen bonds with leucine A:728 residues through nitrogen, which has a very special and vital role in biological sciences and pharmaceutical connections. In this study, it was found that these compounds have the potential to become an oral anti-cancer drug.

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Introducing a high throughput nanocatalytic method toward the synthesis of some pyrazolo phthalazine derivatives under green conditions utilizing imidazoliume based ionic liquid supported on the silica-coated nanosized perlite as a novel, reusable and eco-friendly nanocatalyst

Cited by 2 publications

References 82 publications

Synthesis of 1, 2-Disubstituted Benzimidazoles at Ambient Temperature Catalyzed by 1-Methylimidazolium Tetraflouroborate ([Hmim] BF_4) and Investigating Their Anti-ovarian Cancer Properties Through Molecular Docking Studies and Calculations

Synthesis of 1, 2-Disubstituted Benzimidazoles at Ambient Temperature Catalyzed by 1-Methylimidazolium Tetraflouroborate ([Hmim] BF_4) and Investigating Their Anti-ovarian Cancer Properties Through Molecular Docking Studies and Calculations

A Novel One-Pot Three-Component Approach to Orthoaminocarbonitrile Tetrahydronaphthalenes Using Triethylamine (Et_3N) as a Highly Efficient and Homogeneous Catalyst Under Mild Conditions and Investigating Its Anti-cancer Properties Through Molecular Docking Studies and Calculations

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