Mono- and binuclear copper(II) complexes of the bipyridine ligand: Structural, electrochemical and biological studies

Jayamani, Arumugam; Sengottuvelan, Nallathambi; Kang, Sung Kwon; Kim, Young-Inn

doi:10.1016/j.poly.2015.05.042

Cited by 13 publications

(8 citation statements)

References 75 publications

(62 reference statements)

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“…The values of M–N and M–O bond lengths observed for mononuclear complexes ( 2 )–( 4 ) fall in the range reported for similar compounds with mixed ligands: 2,2′-bipyridine/2,2′-bipyridine derivatives and carboxylato derivatives (Table 5) [44,45,46,47,48]. …”

Section: Resultssupporting

confidence: 63%

Synthesis, Structural Characterization, Antimicrobial Activity, and In Vitro Biocompatibility of New Unsaturated Carboxylate Complexes with 2,2′-Bipyridine

Scăeţeanu

Chifiriuc

Bleoţu³

et al. 2018

Molecules

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The synthesis, structural characterization, cytotoxicity, and antimicrobial properties of four new complexes formed by employing acrylate anion and 2,2′-bipyridine are reported herein. X-ray crystallography revealed the trinuclear nature of [Mn3(2,2′-bipy)2(C3H3O2)6] (1), meanwhile complexes with general formula [M(2,2′-bipy)(C3H3O2)2(H2O)x]∙yH2O ((2) M: Ni, x = 1, y = 0; (3) M: Cu, x = 1, y = 0; (4) M: Zn, x = 0, y = 1; 2,2′-bipy: 2,2′-bipyridine; C3H3O2: acrylate anion) were shown to be mononuclear. The lowest minimum inhibitory concentration (MIC) of 128 μg mL−1 was recorded for all four tested complexes against Candida albicans, for complex (3) against Escherichia coli, and for complex (4) against Staphylocococcus aureus. Compounds (3) and (4) were also potent efflux pumps activity inhibitors (EPI), proving their potential for use in synergistic combinations with antibiotics. Complexes (1)–(4) revealed that they were not cytotoxic to HCT-8 cells. They also proved to interfere with the cellular cycle of tumour HCT-8 cells by increasing the number of cells found in the S and G2/M phases. Taken together, these results demonstrate the potential of zinc and copper complexes for use in the development of novel antimicrobial and anti-proliferative agents.

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Section: Resultssupporting

confidence: 63%

Synthesis, Structural Characterization, Antimicrobial Activity, and In Vitro Biocompatibility of New Unsaturated Carboxylate Complexes with 2,2′-Bipyridine

Scăeţeanu

Chifiriuc

Bleoţu³

et al. 2018

Molecules

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“…The presence of lattice water in complex 2 gives stronger intramolecular bonding in the complex compared to a similar reported system. 27 Complex 2 shows intermolecular π-π interactions similar to those observed in 1. The striking feature of these two complexes is the presence of the hydrogen bonds in the carboxylate anion, perchlorate and the solvation molecules (H 2 O), which resulted in very similar crystal packing of the two compounds in spite of the fact that they crystallized in different crystal systems (monoclinic for 1 and triclinic for 2) with 1 being non-centric and 2 centric.…”

Section: Synthesis Of [Cu(bipy) 2 (Ch 3 Coo)](clo 4 )⋅H 2 O (2)mentioning

confidence: 62%

Synthesis, characterization, electrochemical studies and X-ray structures of mixed-ligand polypyridyl copper(II) complexes with the acetate

Adekunle

Butcher

Bakare

et al. 2016

JSCS

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[Cu(phen)2(CH3COO)](ClO4).2H2O (1) and [Cu(bipy)2(CH3COO)]-(ClO4).H2O (2) {phen = 1,10-phenanthroline, bipy = 2,2?-bipyridine}were synthesized and characterized. The complexes were characterized by employying elemental analyses, infrared and UV-Visible spectroscopy, room temperature magnetic measurements and the crystal structures elucidated using X-ray diffraction experiment. The redox properties of the complexes were also investigated. Both structures have a square pyramidal CuN4O chromophore which exhibit significant distortions due to long Cu-O [2.217(3) ? for (1) and 2.179 (1) for (2)] and Cu-N [2.631(2) ? for (1) and 2.714(1) ? for (2)] bonds. This distortion if further shown by the O-Cu-N bond angles [147.71(8) o for (1) and 153.40(5) o for (2)]. The elemental analyses further support the structural details unveiled by the single crystal X-ray diffraction analysis. The infrared spectra shows the acetate vibrational frequencies at 1587 cm-1,1428 cm-1, 1314 cm-1 for (1) and 1571 cm-1, 1441 cm-1, 1319c m-1 for (2) and the perchlo-rate bands at 1059 cm-1, 720 cm-1 (1) and 1080 cm-1,768 cm-1 (2). The broad d-d bands for the copper ion at 14,514 cm-1(1) and 14,535 cm-1(2) support the adoption of square pyramid geometries. The magnetic moments for the two complexes are 1.83 B.M for (1) and 1.72 B.M for (2). The peak to peak values of the two complexes show that the electrode reactions are quasi-reversibile with ?Ep = 0.023V (1) and 0.025V for (2). In both structures, there are ?-? intermolecular interactions in addition to hydrogen bonding between the units.

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“…We were unable to isolate crystals of 1 2+ of sufficient quality for SCP-XAS measurements; by exchanging the BF 4 – counterion of 1 2+ for ClO 4 – , we were able to grow adequate crystals of 1 2+ -(ClO 4 ) 2 (see the Supporting Information for experimental details). The crystal structure of 1 2+ -(ClO 4 ) 2 has been previously determined using single-crystal X-ray diffraction Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…The crystal structure of 1 2+ -(ClO 4 ) 2 has been previously determined using single-crystal X-ray diffraction. 35 1 2+ -(ClO 4 ) 2 crystallizes as thin rods in the triclinic space group P1̅ , with 2 molecules per unit cell (Figure 3). Unlike 1 2+ , which is 4-coordinate, the Cu center of 1 2+ -(ClO 4 ) 2 is 6-coordinate, as it has close contacts with two ClO 4 − units (Cu−O = 2.522(8) and 2.720(9) Å) within the summed van der Waals radii of 2.92 Å.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Scrutinizing “Ligand Bands” via Polarized Single-Crystal X-ray Absorption Spectra of Copper(I) and Copper(II) Bis-2,2′-bipyridine Species

et al. 2020

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High-energy resolution fluorescence-detected Cu K-edge Xray absorption spectroscopy (XAS) and single-crystal polarized XAS data are presented toward refining the assignments of bands assigned as excitations from Cu 1s to ligand-localized molecular orbitals. These have been previously dubbed "XAS-metal−ligand charge transfer" (XAS-MLCT) bands. Data are presented for a series of [Cu(xbpy) 2 ] n+ complexes (xbpy = 2,2′-bipyridine (1 n+ ), 4,4′-bisamino-2,2′-bipyridine (2 n+ ), and 4,4′dimethoxy-2,2′-bipyridine (3 n+ ); n = 1 and 2). Dipolar dependencies of these "XAS-MLCT" bands in both Cu 1+ and Cu 2+ species lead to reassignment of these features as owing their intensities primarily to Cu 1s → Cu 4p excitations. The transition densities are Cu-localized, highlighting that XAS-MLCT features in Cu XAS spectra are not "charge transfer" transitions but rather quasi-atomic transitions. Although scrutiny of the acceptor orbitals supports assignment as Cu 1s → ligand π* transitions, it ultimately appears that while the ligand orbital energetics govern the positions of these bands the intensity is conferred through a small degree of metal 4p mixing into otherwise ligand-dominated acceptor molecular orbitals.

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Mono- and binuclear copper(II) complexes of the bipyridine ligand: Structural, electrochemical and biological studies

Cited by 13 publications

References 75 publications

Synthesis, Structural Characterization, Antimicrobial Activity, and In Vitro Biocompatibility of New Unsaturated Carboxylate Complexes with 2,2′-Bipyridine

Synthesis, Structural Characterization, Antimicrobial Activity, and In Vitro Biocompatibility of New Unsaturated Carboxylate Complexes with 2,2′-Bipyridine

Synthesis, characterization, electrochemical studies and X-ray structures of mixed-ligand polypyridyl copper(II) complexes with the acetate

Scrutinizing “Ligand Bands” via Polarized Single-Crystal X-ray Absorption Spectra of Copper(I) and Copper(II) Bis-2,2′-bipyridine Species

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