Synthesis, Structural Characterization, Antimicrobial Activity, and In Vitro Biocompatibility of New Unsaturated Carboxylate Complexes with 2,2′-Bipyridine

Abstract

The synthesis, structural characterization, cytotoxicity, and antimicrobial properties of four new complexes formed by employing acrylate anion and 2,2′-bipyridine are reported herein. X-ray crystallography revealed the trinuclear nature of [Mn3(2,2′-bipy)2(C3H3O2)6] (1), meanwhile complexes with general formula [M(2,2′-bipy)(C3H3O2)2(H2O)x]∙yH2O ((2) M: Ni, x = 1, y = 0; (3) M: Cu, x = 1, y = 0; (4) M: Zn, x = 0, y = 1; 2,2′-bipy: 2,2′-bipyridine; C3H3O2: acrylate anion) were shown to be mononuclear. The lowest minimum inhibitory concentration (MIC) of 128 μg mL−1 was recorded for all four tested complexes against Candida albicans, for complex (3) against Escherichia coli, and for complex (4) against Staphylocococcus aureus. Compounds (3) and (4) were also potent efflux pumps activity inhibitors (EPI), proving their potential for use in synergistic combinations with antibiotics. Complexes (1)–(4) revealed that they were not cytotoxic to HCT-8 cells. They also proved to interfere with the cellular cycle of tumour HCT-8 cells by increasing the number of cells found in the S and G2/M phases. Taken together, these results demonstrate the potential of zinc and copper complexes for use in the development of novel antimicrobial and anti-proliferative agents.

A Promising Copper(II) Complex as Antifungal and Antibiofilm Drug against Yeast Infection

“…Recent years have shown increasing number of researches on the development of new antifungal molecules [ 11 , 12 , 13 , 14 ] with better bioavailability, safety, and more effective mechanisms of action for the treatment of infections. The coordination of metallic ions with ligands to obtain liposoluble complexes and carriers of biologically active molecules that can improve the antifungal activity [ 15 ].…”

Preparation, Electronic Properties, and Powder-XRD Structure Analysis of 3,5-Bis(pyridin-2-yl)-H-1,2,4-triazoledichloridocopper(II)

“…The peak at lower energy which is relatively asymmetrical band centered at around 13,000 cm -1 should be the octahedral ligand-field band attributed as 2 E g → 2 T 2g while the one centered at much higher energy, around 23,000-24,000 cm -1 might be associated with the "charge-transfer" band of metalligand, π-π*, and this is what dominates the greenish yellow color of this species. A very clear shoulder band at around 16000 cm -1 might be associated with Jahn-Teller distortion [16,[23][24] due to primarily asymmetrical electronic configuration in e g 3 orbitals.…”

Construction of Zn(II) Linear Trinuclear Secondary Building Units from A Coordination Polymer Based on α-Acetamidocinnamic Acid and 4-Phenylpyridine

“…Furthermore, the fact that a high number of these types of arrays contain labile solvent molecules on their lateral positions, makes them appropriate for the exchange of either their lateral positions or their carboxylate moieties by polytopic linkers, conserving the pinwheel array and forming 2D or 3D materials [ 16 , 21 , 22 ]. Several complexes presenting this type of structure have been reported using a large variety of metal centers [ 19 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ], being the zinc containing linear trinuclear complexes one of the most employed [ 20 , 29 , 30 , 31 , 32 , 33 , 34 ].…”