Monitoring the effect of PEGylation on polyethylenimine in vivo using nuclear imaging technique

Poly (amino ester) Composed of Poly (ethylene glycol) and Aminosilane Prepared by Combinatorial Chemistry as a Gene Carrier

“…A number of approaches have been tried to overcome cytotoxicity limitation and to make non-viral cationic systems safe (1,6). One of the most successful approaches is the conjugation of nonionic hydrophilic polymer such as poly (ethylene glycol) (PEG) (7)(8)(9).…”

Superfluorinated PEI Derivative Coupled with 99mTc for ASGPR Targeted 19F MRI/SPECT/PA Tri‐Modality Imaging

“…PEI is known for its potential in eliminating metal ions from wastewater by coordination of metal ions with secondary or tertiary amino groups in PEI. [30] As expected, the PEI derivative can become complex with reduced 99m Tc without additional bifunctional chelating agent, making it a true MRI/SPECT dual-mode reagent. Similarly, ICG molecules were ion-paired with cationic PEI based on the unique structural characteristics.…”

“…In addition to the ability to target hepatocytes, attachment of LA to PEI could also improve the water solubility. [25,30] The reaction process is a compromise between the fluorine concentration and the water solubility. As a result, superfluorinated nuclear imaging agent with high 19 obtained by the design ideas shown above.…”

Rationally Designed Synthetic Vectors for Gene Delivery

“…This shielding neutralizes the surface charge and also reduces non-specific interactions of the nanoparticles with the cell membrane and other positively charged macromolecules in vivo. Several groups, including ours, have observed lower toxicity with "PEGylated" polyplexes [122,123]. Polyplexes modified with PEG have reduced non-specific interactions and improved circulation times in vivo.…”