Monitoring the aggregation behaviour of self-assembling polymers through high-resolution ultrasonic spectroscopy

Cespi, Marco; Bonacucina, Giulia; Mencarelli, Giovanna; Pucciarelli, Stefania; Giorgioni, Gianfabio

doi:10.1016/j.ijpharm.2009.12.053

Cited by 17 publications

(12 citation statements)

References 35 publications

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“…All the analyzed batches showed very similar sol-gel rheological profiles and comparable values of the moduli at all temperatures, suggesting a good batch-to-batch reproducibility. The gelling behavior of these formulations is comparable to that reported in the literature for Poloxamer 407 hydrogels at the same concentration (24,25,30,31).…”

Section: Characterization Of the Thermosensitive Gelling Systemsupporting

confidence: 84%

Influence of Testing Parameters on In Vitro Tramadol Release from Poloxamer Thermogels using the Immersion Cell Method

et al. 2017

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The immersion cell is an in vitro performance test of drug release from semisolids. Several studies made use of immersion cells to investigate drug release from thermosensitive Poloxamer-based gels; however, specifications on the parameter setting are not yet available. Therefore, the aim of this study was to evaluate the influence of testing parameters on tramadol (a model drug) release, release rate, and dissolution efficiency (DE) from Poloxamer gels, using immersion cells. The thermosensitive gelling formulation showed batch-to-batch uniformity of gelling behavior, drug content, and drug release. The use of a membrane in the immersion cell resulted in slower drug release as compared to the absence of a membrane. Moreover, the faster the paddle rotation, the faster the drug release was. Membrane thickness showed a strong and significant linear relationship with corresponding DE values (Pearson's correlation coefficient, r = -0.9470; p = 0.004). Factors that did not influence drug release include paddle position, i.e., distance between paddle and membrane, as well as membrane mean pore size. This study sets forth the importance of carefully controlling the following parameters including presence/absence of membrane, paddle rotation speed, and membrane thickness during the setup of release experiments from gels using immersion cells.

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Section: Characterization Of the Thermosensitive Gelling Systemsupporting

confidence: 84%

Influence of Testing Parameters on In Vitro Tramadol Release from Poloxamer Thermogels using the Immersion Cell Method

et al. 2017

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“…The aim of this work is to develop an alternative method of analysis based on the variation of sound speed when polymeric hydrogels are mixed with mucin. As previously reported (17), when no interaction occurs between polymers, the relative sound speed of the whole system is equal to the sum of the relative sound speeds of each component since the hydration layer of the molecules remains unchanged. The term relative indicates that sound speed refers only to a pure component within a solution.…”

Section: Introductionsupporting

confidence: 60%

Evaluation of Polymer Mucoadhesiveness by the Use of Acoustic Spectroscopy

et al. 2010

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An innovative and simple methodology has been developed and used for the evaluation of mucoadhesive properties of several polymers by means of sound speed measurements using high-resolution acoustic spectroscopy. In systems made of polymers in water, variations in hydration shell of polymeric chains determine changes of dispersions compressibility, and this phenomenon can be monitored by sound speed measurements. Four different polymers have been selected, namely PEG 6000, Carbopol 974, HPMC K4M, and Pectin 200/USP, all characterised by very different mucoadhesive properties. Samples made of each polymer alone (0.3-1.0% w/w) or in mixture with mucin (mucin fixed at 1.0% w/w) in water were investigated while using high-resolution ultrasonic spectrometer at two different frequencies (5.2 and 8.2 MHz). Polymer-mucin interaction was evaluated comparing experimental sound speed values of polymer-mucin samples with their theoretical values derived from the addition of sound speeds obtained while analysing each component alone. Results demonstrated the ability of the acoustic method to discriminate between mucoadhesive and no mucoadhesive polymer-mucin dispersions and allowed also the comparison between their mucoadhesive strengths. The study has therefore demonstrated the potential of using high-resolution ultrasonic spectroscopy to evaluate the polymers' mucoadhesiveness, with the great advantage of testing small amount of samples even if opaque.

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“…As the temperature of the system increases, the poloxamer molecules aggregate to form micelles which in turn interact to form the gel network. Both micellization and gelation can be considered as consecutive and superimposed dehydration processes (20), so that any solute able to interact with water or enhance the solubility of the poloxamer blocks can affect the behaviour of the selfaggregation (21).…”

Section: Screening and Optimization Of The Crystallization Systemsmentioning

confidence: 99%

Poloxamer Thermogel Systems as Medium for Crystallization

et al. 2011

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Monitoring the aggregation behaviour of self-assembling polymers through high-resolution ultrasonic spectroscopy

Cited by 17 publications

References 35 publications

Influence of Testing Parameters on In Vitro Tramadol Release from Poloxamer Thermogels using the Immersion Cell Method

Influence of Testing Parameters on In Vitro Tramadol Release from Poloxamer Thermogels using the Immersion Cell Method

Evaluation of Polymer Mucoadhesiveness by the Use of Acoustic Spectroscopy

Poloxamer Thermogel Systems as Medium for Crystallization

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