Influence of Testing Parameters on In Vitro Tramadol Release from Poloxamer Thermogels using the Immersion Cell Method

Bisharat, Lorina; Perinelli, Diego Romano; Berardi, Alberto; Bonacucina, Giulia; Logrippo, Serena; El‐Hajji, Feras Darwish; Cespi, Marco

doi:10.1208/s12249-017-0753-x

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…At temperatures below the T sol-gel , the values of G* were low, indicating the liquid-like behavior of systems; a dramatic increase of G* occurred above 24 • C, demonstrating the gelation of the formulations. All the analyzed samples showed very similar sol-gel rheological profiles, confirming the previously obtained results that are very similar to those reported in literature when the same concentration of P407 is used to obtain hydrogels [79][80][81].…”

Section: Dynamic Rheological Measurementssupporting

confidence: 90%

Rutin-Loaded Poloxamer 407-Based Hydrogels for In Situ Administration: Stability Profiles and Rheological Properties

et al. 2020

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Rutin is a flavone glycoside contained in many plants, and exhibits antioxidant, anti-inflammatory, anticancer, and wound-healing properties. The main disadvantage related to the use of this molecule for pharmaceutical application is its poor bioavailability, due to its low solubility in aqueous media. Poloxamer 407-hydrogels show interesting thermo-sensitive properties that make them attractive candidates as pharmaceutical formulations. The hydrophobic domains in the chemical structure of the copolymer, a polymer made up of two or more monomer species, are useful for retaining poorly water-soluble compounds. In this investigation various poloxamer 407-based hydrogels containing rutin were developed and characterized as a function of the drug concentration. In detail, the Turbiscan stability index, the micro- and dynamic rheological profiles and in vitro drug release were investigated and discussed. Rutin (either as a free powder or solubilized in ethanol) did not modify the stability or the rheological properties of these poloxamer 407-based hydrogels. The drug leakage was constant and prolonged for up to 72 h. The formulations described are expected to represent suitable systems for the in situ application of the bioactive as a consequence of their peculiar versatility.

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Section: Dynamic Rheological Measurementssupporting

confidence: 90%

Rutin-Loaded Poloxamer 407-Based Hydrogels for In Situ Administration: Stability Profiles and Rheological Properties

et al. 2020

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Hydrogel containing mPEG-PLGA nanoparticles for the vaginal delivery of saquinavir mesylate against HIV infection

Tiboni,

Cespi,

Casettari

et al. 2023

European Journal of Pharmaceutical Sciences

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In Vitro Release Testing of Acyclovir Topical Formulations Using Immersion Cells

Kulkarni

Potdar

Date

et al. 2021

ASSAY and Drug Development Technologies

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The objective of the study was to reinforce the applicability of the immersion cells for the in vitro release testing (IVRT) of topical formulations by using marketed acyclovir 5% cream formulation (Cream 1) as a model. The method employing the immersion cells was optimized by studying the effect of variables, such as membrane type, media temperature and volume, agitation speed, and cell size, on acyclovir release from the formulation. The in-house formulation similar to the qualitative and quantitative composition of Cream 1 and the other trial formulations with variable compositions were prepared and studied by using the immersion cells. Various other brands of acyclovir topical formulations available in the Indian market were also subjected to IVRT by using the optimized method. An increase in the media temperature from 32°C to 37°C and the stirring speed from 50 to 100 to 150 rpm led to an increase in the drug release. As the immersion cell size increased (0.5, 2 and 4 cm 2 surface area), the release rate also increased. Nitrocellulose membrane showed the highest drug release and Fluoropore Ô the least. The optimized IVRT method could establish the differences in the drug release rates among the formulations with the altered compositions. The method could also prove its discriminatory potential for various marketed formulations. The immersion cell method could serve as a simpler, facile, and reliable aid during product development and also as a quality control tool in assessing stability, aging, and batch-tobatch uniformity of semisolid formulations.

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Influence of Testing Parameters on In Vitro Tramadol Release from Poloxamer Thermogels using the Immersion Cell Method

Cited by 3 publications

References 27 publications

Rutin-Loaded Poloxamer 407-Based Hydrogels for In Situ Administration: Stability Profiles and Rheological Properties

Rutin-Loaded Poloxamer 407-Based Hydrogels for In Situ Administration: Stability Profiles and Rheological Properties

Hydrogel containing mPEG-PLGA nanoparticles for the vaginal delivery of saquinavir mesylate against HIV infection

In Vitro Release Testing of Acyclovir Topical Formulations Using Immersion Cells

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