Monitoring of tissue optical properties during thermal coagulation of ex vivo tissues

Nagarajan, Vivek Krishna; Yu, Bing

doi:10.1002/lsm.22541

Cited by 25 publications

(24 citation statements)

References 56 publications

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“…Increases in tissue m a and m s 0 due to heating have also been reported by many groups in different types of soft tissues [18][19][20] and our observation is in accordance with previously reported studies. Tissue m a (k) and m s 0 (k) are indicative of both the structural and physiological state of the tissue.…”

Section: Discussionsupporting

confidence: 83%

“…Light propagation within a biological tissue is sensitive to the tissue morphology and physiology. Specifically, quantitative optical spectroscopy can determine the optical properties of normal vs. coagulated tissue, with higher m a (k) and m s 0 (k) seen in coagulated tissues [18][19][20]. Although changes in tissue optical properties are due to denaturation, the correlation between tissue absorption and reduced scattering coefficient and true tissue damage are yet to be established.…”

Section: Introductionmentioning

confidence: 99%

“…In our previous study [13,18], we have shown that m a and m s 0 in porcine muscle tissues measured by diffuse reflectance spectroscopy (DRS), at selected temperature points, correlated with the degree of denaturation (F d ) derived from the Arrhenius damage model. In addition, we determined that continuous monitoring of m a and m s 0 is necessary to achieve the endpoint for ablation.…”

Section: Introductionmentioning

confidence: 99%

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Real time evaluation of tissue optical properties during thermal ablation of ex vivo liver tissues

Nagarajan

Gogineni

White

et al. 2018

International Journal of Hyperthermia

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Complete ablation of liver tumors is vital for minimizing the risk of local tumor recurrence. Accurately identifying the hallmarks of tissue necrosis during thermal ablative therapies may significantly increase the efficacy of ablation, while minimizing unnecessary damage to the surrounding normal tissues or critical structures. Light propagation in biological tissues is sensitive to the tissue microstructure and chromophore concentrations. In our previous studies, we found that the wavelength (k) averaged liver tissue absorption coefficient (m a ) and reduced scattering coefficient (m s 0 ) change significantly upon heating which may be used for assessment of tissue damage during thermal ablation of solid tumors. Here, we seek to demonstrate the use of an integrated fiber-optic probe for continuous monitoring of the local tissue temperature (T), m a (k) and m s 0 (k) during thermal ablation of ex vivo porcine livers. The wavelength-averaged (435-630 nm) tissue absorption and scattering (m a and m s 0 ) increased rapidly at 45 C and plateaued at 67 C. The mean m a and m s 0 for liver tissue at 37 C (n ¼ 10) were 8.5 ± 3.7 and 2.8 ± 1.1 cm À1 , respectively. The relative changes in m a and m s 0 at 37, 55, and 65 C were significantly different (p < .02) from each other. A relationship between the relative changes in m a and m s 0 and the degree of tissue damage estimated using the temperature-based Arrhenius model for porcine liver tissues was established and studied.ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Real time evaluation of tissue optical properties during thermal ablation of ex vivo liver tissues

Nagarajan

Gogineni

White

et al. 2018

International Journal of Hyperthermia

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“…This is advantageous for minimally invasive measurement compared to the fiber probes used in . Besides, fiber‐based measurement system is potable and cost effective and also avoids unfavorable effects brought by sample handling . According to our previous study , μ ′ s (690 nm) had obvious relevance with liver ablation damage degree.…”

Section: Discussionmentioning

confidence: 99%

“…Fully ablated tissue had μ ′ s (690 nm) value of 17 to 19 cm −1 , which was about 5 times higher than native tissue. Similar dynamic changes were also reported in .…”

Section: Discussionmentioning

confidence: 99%

Feasibility study of modeling liver thermal damage using minimally invasive optical method adequate for in situ measurement

Zhao

Jiang

et al. 2018

Journal of Biophotonics

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Liver thermal ablation techniques have been widely used for the treatment of liver cancer. Kinetic model of damage propagation play an important role for ablation prediction and real-time efficacy assessment. However, practical methods for modeling liver thermal damage are rare. A minimally invasive optical method especially adequate for in situ liver thermal damage modeling is introduced in this paper. Porcine liver tissue was heated by water bath under different temperatures. During thermal treatment, diffuse reflectance spectrum of liver was measured by optical fiber and used to deduce reduced scattering coefficient (μ ). Arrhenius parameters were obtained through non-isothermal heating approach with damage marker of μ . Activation energy (E ) and frequency factor (A) was deduced from these experiments. A pair of averaged value is 1.200 × 10 J mol and 4.016 × 10 s . The results were verified for their reasonableness and practicality. Therefore, it is feasible to modeling liver thermal damage based on minimally invasive measurement of optical property and in situ kinetic analysis of damage progress with Arrhenius model. These parameters and this method are beneficial for preoperative planning and real-time efficacy assessment of liver ablation therapy.

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Investigation of nonlinear photoacoustic microscopy using a low‐cost infrared lamp

Seong

Yang

Han

et al. 2022

Journal of Biophotonics

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Nonlinear photoacoustic microscopy (PAM) is a novel approach to enhance contrast and resolution. In this study, a low‐cost infrared (IR) lamp as a simple approach for nonlinear PAM is demonstrated. Numerical simulations are first performed to verify the nonlinear photoacoustic effect under steady heating for two cases: (a) Differentiation of absorbers with different Grüneisen coefficients; (b) enhancement of photoacoustic amplitude. Then, sets of experiments are conducted to experimentally demonstrate our proposed approach: (a) Longitudinal monitoring of photoacoustic A‐line signals from two samples, porcine tissue ex vivo and hemoglobin and indocyanine green (ICG) solutions in tubes in vitro for demonstrating the above‐mentioned two cases; (b) PAM imaging of hemoglobin and ICG solutions in tubes before and after IR lamp heating. Different signal change and amplitude enhancement are observed in different demonstrations, showing the efficacy of the proposed approach. By virtue of cost‐effectiveness and decent performance, our work facilitates nonlinear PAM studies.

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Monitoring of tissue optical properties during thermal coagulation of ex vivo tissues

Abstract: The changes in optical absorption and scattering properties can be continuously quantified, which could be used as a diagnostic biomarker for assessing tissue coagulation/damage during thermal ablation. Lasers Surg. Med. 48:686-694, 2016. © 2016 Wiley Periodicals, Inc.

Cited by 25 publications

References 56 publications

Real time evaluation of tissue optical properties during thermal ablation of ex vivo liver tissues

Real time evaluation of tissue optical properties during thermal ablation of ex vivo liver tissues

Feasibility study of modeling liver thermal damage using minimally invasive optical method adequate for in situ measurement

Investigation of nonlinear photoacoustic microscopy using a low‐cost infrared lamp

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