Monitoring of polyphenol mangiferin by liquid chromatography tandem mass spectrometry in rat and its comparative pharmacokinetic study of a single compound, a single botanic extract and multiple botanic extract

Abstract

The aim of this study is to develop a sensitive, validated specific performance liquid chromatography tandem mass spectrometry method to analysis of spinosin, jujuboside A, jujuboside B, mangiferin, pachymic acid, ferulic aid, and glycyrrhizic acid in herbal preparations. This validated method was further applied to a comparative study on the pharmacokinetics and oral bioavailability of mangiferin following administration of mangiferin (a single compound), Anemarrhenae Rhizoma extracts (a single‐herb extract), and a multiple botanic Anemarrhenae Rhizoma extract. A conscious and freely moving rat model was used for pharmacokinetic study of mangiferin. A parallel study was divided into four treatments to investigate the oral bioavailability of mangiferin, single compound of mangiferin (3 mg/kg, i.v.), mangiferin (38 mg/kg, p.o.), and a single botanic Anemarrhenae Rhizoma extracts (2.85 g/kg, p.o.), and a multiple botanic Anemarrhenae Rhizoma extract (10 g/kg, p.o.). The above oral doses of botanic extract were equivalently to mangiferin (38 mg/kg, p.o.). The pharmacokinetic results demonstrated that the oral bioavailability of mangiferin for the single compound administration (0.6%) was significantly lower than that of both the single Anemarrhenae Rhizoma extracts (6.2%) and a multiple botanic Anemarrhenae Rhizoma extract (3.0%). This phenomenon may be due to herbal ingredient‐ingredient or botanic‐botanic interactions.

The Role of High-Resolution Analytical Techniques in the Development of Functional Foods

“…In addition, this approach was applied for the quantification of seven catechins in rat plasma [ 95 ]. This method was also applied by Chang et al for the determination and quantification of mangiferin, single Anemarrhenae Rhizoma extract and multiple botanic extract of Suan-Zao-Ren decoction (SZRD) in rat plasma [ 107 ]. Zhang et al also verified that this UHPLC–MS/MS method is suitable for the separation and simultaneous determination of two bioactive compounds (angoroside C and its metabolite ferulic acid) in biological samples from rats [ 104 ].…”

Farmakokinetika dan Bioavailability Senyawa Golongan Santon Revew Komprehensif

“…Penelitian pada tikus yang diberikan mangiferin secara oral dan intra vena memperlihatkan bioavailabilitas yang sangat rendah pada pemberian oral yaitu F= 1.2% . Bioavailabilitas mangiferin dilaporkan lebih tinggi ketika diberikan dalam bentuk ekstrak tumbuhan Anemarhanae Rhizoma ataupun dekokta Anemarhanae Rhizoma yang mengandung mangiferin (Liu et al 2010;Chang et al 2018). Bioavailabilitas yang rendah dari mangiferin disebabkan oleh absorpsi yang kurang baik di saluran cerna dan juga akibat First Pass Effect (Tian et al 2016;Gu et al 2019).…”

Pharmacokinetic Change of Glycyrrhetinic Acid from the Roots and Rhizomes of Glycyrrhiza uralensis by Coadministration with the Rhizomes of Atractylodes japonica, A. macrocephala, or A. chinensis in an Animal Model

“…Herbal combinations also influence the pharmacokinetic features of the herbal constituents after oral administration. The absorption, distribution, metabolism, and elimination of compounds from a single herb may be changed in herbal combinations, and hence the pharmacokinetic parameters of herbs in combination can be somewhat unexpected (Zhang et al 2015;Chang et al 2018). These changes influence absorption, bioaccumulation, gastrointestinal permeability, and excretion (Shi et al 2015;Wang et al, 2016a) and, thus, alter bioavailability (Mao et al, 2017a).…”