Monitoring of HIV viral loads, CD4 cell counts, and clinical assessments versus clinical monitoring alone for antiretroviral therapy in rural district hospitals in Cameroon (Stratall ANRS 12110/ESTHER): a randomised non-inferiority trial

Laurent, Christian; Kouanfack, Charles; Laborde‐Balen, Gabrièle; Aghokeng, Avelin F.; Mbougua, Jules Brice Tchatchueng; Boyer, Sylvie; Carrieri, Patrizia; Mben, Jean-Marc; Dontsop, Marlise; Kazé, Serge; Molinari, Nicolas; Bourgeois, Anke; Mpoudi‐Ngolé, Eitel; Spire, Bruno; Koulla‐Shiro, Sinata; Delaporte, Eric

doi:10.1016/s1473-3099(11)70168-2

Cited by 91 publications

(115 citation statements)

References 21 publications

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“…In total, nine studies were fully reviewed and four were excluded for the following reasons: two focused solely on patients taking anti-retroviral therapy (ART) (Kunutsor et al, 2011;Laurent et al, 2011), one examined the effect of a housing intervention (not a healthcare intervention) (Kidder et al, 2007) and one study (L.I. Gardner et al, 2009) was excluded as it reported secondary analysis of a study included in the review (L.I.…”

Section: Description Of Studiesmentioning

confidence: 99%

A systematic review of health service interventions to improve linkage with or retention in HIV care

2013

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The importance of early linkage to and continuing retention in HIV care is increasingly recognised, particularly in light of the implications poor linkage and retention rates have for the effectiveness of HIV treatment as prevention strategies. The purpose of this systematic review was to examine the effectiveness of healthcare interventions in improving patient linkage to or retention in HIV care. We systematically searched PubMed (MEDLINE and PubMed-only citations) and EMBASE databases for articles reporting the original results of randomised controlled trials, and used a standard data collection form to extract information on study characteristics and outcome data. Five articles met the inclusion criteria, of which two articles focused on linkage to care and three on retention in care. The methodological quality, both of internal and external validity, of most of the trials was suboptimal. Wide variation in the interventions and outcome measures meant synthesis of the results using meta-analysis was not appropriate. This review shows evidence that interventions based on supporting patient self-management improves linkage to, and possibly retention in, care. Interventions aimed at delivery service design may also be effective, although evidence in this review was limited. It is vital that interventions are developed to improve patient engagement in HIV care. The dearth of research identified by this review highlights the need for well-designed trials of interventions in this area in the future.

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Section: Description Of Studiesmentioning

confidence: 99%

A systematic review of health service interventions to improve linkage with or retention in HIV care

2013

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“…Where viral load monitoring is unavailable, clinical monitoring and CD4 monitoring are recommended (205). Although a systematic review of two randomized controlled trials (184,206) provide moderate-quality evidence of mortality and morbidity benefits with CD4 and clinical monitoring compared with routine clinical monitoring in adults receiving ART, these trials largely focused on CD4 and clinical monitoring in people who initiated ART at CD4 counts below 200 cells/mm 3 (Web Annex www.who.int/hiv/pub/guidelines/arv2013/annexes).…”

Section: Immunological Monitoring Versus Clinical Monitoringmentioning

confidence: 99%

Non-AIDS Morbidity among HIV Patients

Kim¹

2016

Korean J Med

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“…The resistance testing is actually an HIV-1 genotyping assay where the protease and the reverse transcriptase conserved regions of the pol gene are amplified and sequenced, as described by Fokam et al [107]. Only two commercial tests approved by the Food and Drug Administration are currently available, and have been used widely to follow-up patients under antiretroviral treatment [108,109,110] and to report drug resistance mutations in HIV-1 reverse transcriptase or protease [109,111,112]. However, such commercial kits are very expensive for resource-limited countries like those of Central Africa and also their performance is questionable because of the great diversity of strains found in that region.…”

Section: Pcr Allows the Management Of Hiv Infectionmentioning

confidence: 99%

Application of PCR Technologies to Humans, Animals, Plants and Pathogens from Central Africa

Odile¹,

Migot-Nabias²,

Born³

et al. 2012

Polymerase Chain Reaction

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Monitoring of HIV viral loads, CD4 cell counts, and clinical assessments versus clinical monitoring alone for antiretroviral therapy in rural district hospitals in Cameroon (Stratall ANRS 12110/ESTHER): a randomised non-inferiority trial

Cited by 91 publications

References 21 publications

A systematic review of health service interventions to improve linkage with or retention in HIV care

A systematic review of health service interventions to improve linkage with or retention in HIV care

Non-AIDS Morbidity among HIV Patients

Application of PCR Technologies to Humans, Animals, Plants and Pathogens from Central Africa

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