Monitoring of Antihypertensive Treatment for Left Ventricular Mass Regression

Hashimoto, Junichiro; Imai, Yohsuke; O’Rourke, Michael

doi:10.1016/j.hlc.2007.06.168

Cited by 25 publications

(33 citation statements)

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“…53 Moreover, the predictive power of PP amplification was superior to carotid PP. In untreated subjects with essential hypertension, 54 regression of left ventricular mass index after 1 year of drug treatment was independently associated with the increase of PP amplification, but not with the reduction in brachial PP. Further evidence is still awaited.…”

Section: Clinical Implications Of Pulse Pressure Amplificationmentioning

confidence: 78%

Role of Pulse Pressure Amplification in Arterial Hypertension

et al. 2009

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Section: Clinical Implications Of Pulse Pressure Amplificationmentioning

confidence: 78%

Role of Pulse Pressure Amplification in Arterial Hypertension

et al. 2009

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“…28 In a clinical setting, these parameters have been reported to be superior to traditional brachial artery blood pressure measurements in predicting future cardiovascular events, and in evaluating the response to drug treatment. [2][3][4][5]29 During pregnancy, the maternal circulation undergoes remarkable physiological adaptations. Normal pregnancy is associated with increased cardiac output, intravascular volume and a marked decrease in vascular resistance.…”

Section: Discussionmentioning

confidence: 99%

Central aortic blood pressure and augmentation index during normal pregnancy

et al. 2012

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The current study tested the hypothesis that pregnancy-related changes are more pronounced in central hemodynamics, and both central aortic systolic blood pressure (cSBP) and augmentation index (AIx) are independent from brachial systolic blood pressure (bSBP) in normal pregnant subjects. In 830 healthy pregnant women from 12 to 36 weeks gestation, we measured cSBP and AIx-75 (AIx at heart rate of 75 beats per minute) non-invasively by pulse waveforms of the radial artery using an automated applanation tonometric system. In 69 pregnant women, we recorded these data longitudinally. cSBP and AIx-75 significantly declined during pregnancy, reaching its nadir in mid-pregnancy and rising towards term. Pregnancy-related changes were more pronounced in AIx-75 compared with cSBP, but less evident in bSBP. AIx-75, but not cSBP, was independent from bSBP throughout pregnancy. cSBP and AIx-75, but not bSBP, were significantly increased in healthy pregnant women older than 35 years. This study established normal values for pulse wave analysis parameters throughout pregnancy, and indicated that pulse wave analysis might offer additional and independent information about maternal arterial compliance to conventional brachial blood pressure measurements. These data may be used as the basis for further investigation into the role of pulse wave analysis in the assessment, management and prediction of disorders, which might interfere with pregnancy-related cardiovascular adaptations.

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“…In addition, the regression of left ventricular hypertrophy during antihypertensive treatment is considered proportional to the reductions in the aortic augmentation index and reflection magnitude (de Luca et al 2004;Hashimoto et al 2007bHashimoto et al , 2008c. Another study showed that the casual (office) central pressure indices can better predict the regression than the home brachial pressure (Hashimoto et al 2007a). These data suggest that left ventricular hypertrophy is a compensating reaction to the central pressure overload as exacerbated by the peripheral wave reflection, and it is (at least partially) reversible by normalizing the central hemodynamics.…”

Section: Central Hemodynamics and Heartmentioning

confidence: 99%

Central Hemodynamics and Target Organ Damage in Hypertension

Hashimoto

2014

Tohoku J. Exp. Med.

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Recent advances in technology have enabled the noninvasive evaluation of pulsatile hemodynamics in the central aorta; namely, central pressure and flow measurements. The central blood pressure represents the true load imposed on the heart, kidney and brain, and the central blood flow influences the local flow into these vital organs. An elevation of the central blood pressure has a direct, adverse impact on the target organ and, thus, the cardiovascular prognosis in patients with hypertension. A decrease in the central blood flow can cause organ dysfunction and failure. The central pressure and flow dynamics were conventionally regarded as unidirectional from the heart to the periphery. However, current evidence suggests that it should be recognized as a bidirectional interplay between the central and peripheral arteries. Specifically, the pressure pulse wave is not only transmitted forward to the periphery but also reflected backward to the central aorta. The flow pulse wave is also composed of the forward and reverse components. Aortic stiffening and arteriolar remodeling due to hypertension not only augment the central pressure by increasing the wave reflection but also may alter the central bidirectional flow, inducing hemodynamic damage/dysfunction in susceptible organs. Therefore, central hemodynamic monitoring has the potential to provide a diagnostic and therapeutic basis for preventing systemic target organ damage and for offering personalized therapy suitable for the arterial properties in each patient with hypertension. This brief review will summarize hypothetical mechanisms for the association between the central hemodynamics and hypertensive organ damage in the heart, kidney and brain.

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Monitoring of Antihypertensive Treatment for Left Ventricular Mass Regression

Cited by 25 publications

References 0 publications

Role of Pulse Pressure Amplification in Arterial Hypertension

Role of Pulse Pressure Amplification in Arterial Hypertension

Central aortic blood pressure and augmentation index during normal pregnancy

Central Hemodynamics and Target Organ Damage in Hypertension

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